ID I3J4Y6_ORENI Unreviewed; 256 AA.
AC I3J4Y6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Protein-lysine methyltransferase METTL21E {ECO:0000313|Ensembl:ENSONIP00000003926.2};
GN Name=LOC102080054 {ECO:0000313|Ensembl:ENSONIP00000003926.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000003926.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000003926.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005466941.1; XM_005466884.2.
DR AlphaFoldDB; I3J4Y6; -.
DR STRING; 8128.ENSONIP00000033554; -.
DR Ensembl; ENSONIT00000003927.2; ENSONIP00000003926.2; ENSONIG00000003133.2.
DR GeneID; 102080054; -.
DR KEGG; onl:102080054; -.
DR CTD; 403183; -.
DR eggNOG; KOG2793; Eukaryota.
DR GeneTree; ENSGT00940000159229; -.
DR HOGENOM; CLU_055721_0_0_1; -.
DR OrthoDB; 2902182at2759; -.
DR TreeFam; TF354267; -.
DR Proteomes; UP000005207; Linkage group LG1.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR019410; Methyltransf_16.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR14614; HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN; 1.
DR PANTHER; PTHR14614:SF1; METHYLTRANSFERASE-LIKE PROTEIN 21E PSEUDOGENE-RELATED; 1.
DR Pfam; PF10294; Methyltransf_16; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 256 AA; 29473 MW; 6DAFE43CF376955B CRC64;
METQQPKTME DPKNRQTDAC KAGPAVDAEL ARAIMARQFH PPVIGPEVWE GYVFSGLEIL
IKESTDLYGA VLWPSAMVLC HFLENNRDKY NLLDKNVIEL GAGTGLVTIV SSLLGAKVTS
TDLPDVLGNL QYNVTRNTKG RCKYTPLVTE LIWGQELNQR FPRATHRFDY ILAADVVYAH
PYLQELMDTF EYLCQENTQI LWAMRFRLDP ENSFVDRFRQ RFHLEELYSL PSLSIKLYRA
WRRDGTTKDL REAAKH
//
