ID   I3J583_ORENI            Unreviewed;       773 AA.
AC   I3J583;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 65.
DE   SubName: Full=Cullin 4A {ECO:0000313|Ensembl:ENSONIP00000004023.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000004023.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000004023.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
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DR   AlphaFoldDB; I3J583; -.
DR   STRING; 8128.ENSONIP00000076782; -.
DR   Ensembl; ENSONIT00000004024.2; ENSONIP00000004023.2; ENSONIG00000003207.2.
DR   eggNOG; KOG2167; Eukaryota.
DR   GeneTree; ENSGT00940000156905; -.
DR   HOGENOM; CLU_004747_7_2_1; -.
DR   TreeFam; TF101153; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000005207; Linkage group LG1.
DR   GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016157; Cullin_CS.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF68; CULLIN-4A; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS01256; CULLIN_1; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          418..646
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
SQ   SEQUENCE   773 AA;  89755 MW;  85760666023EBDBF CRC64;
     LNHTAISQSA NLIMAEDTRQ DKRASFSITE HSANGMARTS AVASGKTGTS KKLVIKNFKD
     RPKLAENYTE DTWLKLRDAV GAIQNSTSIK YNLEELYQAV ENLCSYKVSP TLYKQLRQVC
     EDHVQAQIHQ FREYPFLCSL DNLSFLKRMN RCWQDHCRQT IMIRSIFLFL DRTYVLQNSL
     LPSIWDTGLE LFRTHIVSDS AVQKRTVEGI LEQIELERNG ETVDRSLLRS LLGMLSDLQV
     YKDSFEERFL TETNRLYAAE GQRLMQERDV PEYLHHVARR LEEENDRIVS YLDQSTQKPL
     ISCVEKQLLG EHMTAILQKG LSTLLDENRV TELTLLYQLF SKVKGGLPTL LQFWRDYIKS
     FGGEIVCTPE KDKDMVQDLL DFKDKMDNVA QSCFARNESF INAMKEAFET FINKRPNKPA
     ELIAKYVDSK LRAGNKEATE EELERILDKI MIIFRFIHGK DVFEAFYKKD LAKRLLVGKS
     ASVDAEKSML SKLKHECGAA FTSKLEGMFK DMELSKDIMI QFKQYIQNQS EPSNIELTVN
     ILTMGYWPSY TPMEVHLPTE MVKLQEVFKL FYLGKHSGRK LQWQPTLGHA VLKAEFKEGK
     KELQVSLFQT LVLLMFNEGE EFSMEEIRAA TGIEEGELKR TLQSLACGKA RVLNKNPRGK
     DVEDGDRFNF NNDFKHKLFR IKINQIQMKE TVEEQVSTTE RVFQDRQYQI DAAVVRIMKM
     RKTLSHNLLV SELYNQLKFP VKPGDLKKRI ESLIDRDYME RDKETPNQYH YVA
//