ID I3J5G7_ORENI Unreviewed; 1671 AA.
AC I3J5G7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Bromodomain adjacent to zinc finger domain 2B {ECO:0000313|Ensembl:ENSONIP00000004107.2};
GN Name=BAZ2B {ECO:0000313|Ensembl:ENSONIP00000004107.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000004107.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000004107.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 8128.ENSONIP00000042683; -.
DR Ensembl; ENSONIT00000004108.2; ENSONIP00000004107.2; ENSONIG00000003272.2.
DR eggNOG; KOG1245; Eukaryota.
DR GeneTree; ENSGT00940000155359; -.
DR HOGENOM; CLU_000899_0_0_1; -.
DR TreeFam; TF329083; -.
DR Proteomes; UP000005207; Linkage group LG1.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR CDD; cd01397; HAT_MBD; 1.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR028941; WHIM2_dom.
DR PANTHER; PTHR45915:SF1; BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2B; 1.
DR PANTHER; PTHR45915; TRANSCRIPTION INTERMEDIARY FACTOR; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF15613; WSD; 1.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00391; MBD; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS50982; MBD; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 600..671
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 951..1016
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 395..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 701..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1131..1191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1247..1319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1348..1388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1420..1466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1510..1545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 777..849
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 879..914
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 13..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..274
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..426
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..441
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..589
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1163..1184
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1256..1286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1298..1315
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1420..1438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1439..1453
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1513..1534
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1671 AA; 182351 MW; 0DCD3BC4C418B7FA CRC64;
MESGERLVSP APTLSAARTS SPAASSSSSS SSSSSSSSPA PHSKSSLAPS PSALGSTLSA
SGRLFGAAGE QPFIGSTLSS AFPLVNHPAF GALYTAGAGR PEFGGLGSLG MSAALAAHPQ
LGALSEWWRA AEAHGRGAAA FLPSFIGFPP FFAPHIQSNH SASPVPIRMP GKNSHAAPKG
VNGAVNGSGA CPPVTQSGSF SFVLHSEADF YNAFFFSIQK PRKKTADTSM VSNSESGTSS
DSSSDGSLSS DLEDLAEDDE DDDDDDEDDE EEDKHSELTG TAKNDRPLSG DANRKKGTQA
QKVPSNPPTL VPLPCSVSPP ALSQTSPLAL HSSRSRTEGP QQHFSVIQST GLAANSKPLA
LLTQPRRESF SYIPVWDFIS KGNKCQTASS KLTWPGTLMS QGQTFPAELK KQQQGPNKSP
KRTSLSSSPL PPVPPPPPQN NHSNLFLSSA LLGLPEPHHP NGVIQSTTQD APLALISKPR
KDSASQGKSP QRDADAGSMP VNLSTGANRT QAAGQAGPPS QPPTTSPHSG IGIPGVSIPG
VGIPGVGIPG TCNPTAGLPA NKESDDSGDD DDEEDDDLEE EEDEEDSDDS LSGLGKRKRV
MDEKELMIPL ELGWRRETRI KSVAGRPQGE VAYYAPCGKK LRQYPDVMKY LSRNGISGIT
RDNFSFSAKI RVGDFYEARE GPQGLQWSLL KEEEVIPRIL AMEGRRGRPP NSERQLAGEG
AKGNRRRKGR PPNVGDPLAP EGPSPSQVKL LRKLEAQEIA RQAAQMKLMR KLEKQALARA
AKEARKQQAI MAAEERRKQK EQIKILKQQE KIKRIQQIRM EKELRAQQIL EAKRKKKEEA
ANAKILEAEK RIKVCLQIKL LEKIWKTERE RRRQHVMLMK AVEARKKAEE RERLRQEKRD
EKRLNKERKL EQRRLELEIA RELKKPNEDM CLSDHKALPD FSRIPGLILP GRAVSDCLML
MQFLRGFGKV LGLDVNTDVP TLGMLQEGLL NVGDSMGQVQ DLLVKLLSLA VCDPGLPPGQ
KTKTMLGDHL TNVGINRDNV SEVLQMYMGA HCANTDLAPL ALSLKTKAFQ AHTPAQKASI
LGFLANELAC SKAVISEIDK NLDQMANMRK DKIIMEGKLK KLRTIYAKRT GKREASMGVE
ENQSVGTPSS ATKRKRKLGG DSEDDDDDDD DSDDQPEEEE EEEEEEIKKV KKVETYDEKL
KVCQHHQTRR KLFEISHSLR SMMYGQDRYR RRYWVLPHCG GVFIEAMESG EGSPEELEEE
RQRRRRAAEE VKVKEEPQEI ELQKEKPTNL DGQSVRTQDL EQQKEEEKEH EGKKNSPTLF
YQQPGCVTKL CALREVSKDI APSMVTANDT TNIPPLASSS LSAPCLPAAR ESPGNTPPTS
SPAPSPHLAF QANDQLLRVL TERSGHWFSL LPRNPCDLSS LTTTPSGVPR VSPQASSTPA
RPRSPPPSPA LPLTPSAASA SASPHHPTGI LSYPLSTLQV KSGGSLLGVS FASWPSGMIS
PSLPLCSSPS PMPGHSVEGN TAASVSSKSE SPLPRIEKTC SMPSPALEMP KSLDHAMPRP
IPEEMLTGWW RVSDIEELRA LVNALHSRGI REKALQRQMQ KYMEIIPQVC TKHRDVAMIE
LHELEESQVS VESVRGWCVE EQAMEMDIAI LQQVEELERK VTAASLQVKV K
//
