ID I3J606_ORENI Unreviewed; 600 AA.
AC I3J606;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Lamin-L(III) {ECO:0000313|Ensembl:ENSONIP00000004296.2};
GN Name=LOC100691959 {ECO:0000313|Ensembl:ENSONIP00000004296.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000004296.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000004296.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR RefSeq; XP_003437552.1; XM_003437504.4.
DR AlphaFoldDB; I3J606; -.
DR Ensembl; ENSONIT00000004297.2; ENSONIP00000004296.2; ENSONIG00000003411.2.
DR GeneID; 100691959; -.
DR KEGG; onl:100691959; -.
DR CTD; 195817; -.
DR GeneTree; ENSGT00940000164952; -.
DR OrthoDB; 72418at2759; -.
DR Proteomes; UP000005207; Linkage group LG1.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005635; C:nuclear envelope; IEA:UniProt.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 2.60.40.1260; Lamin Tail domain; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 2.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR001322; Lamin_tail_dom.
DR InterPro; IPR036415; Lamin_tail_dom_sf.
DR PANTHER; PTHR45721; LAMIN DM0-RELATED; 1.
DR PANTHER; PTHR45721:SF16; LAMIN L3; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF00932; LTD; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR SUPFAM; SSF74853; Lamin A/C globular tail domain; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
DR PROSITE; PS51841; LTD; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023289};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Prenylation {ECO:0000256|ARBA:ARBA00023289};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 53..405
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT DOMAIN 448..566
FT /note="LTD"
FT /evidence="ECO:0000259|PROSITE:PS51841"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 404..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 252..351
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 600 AA; 68190 MW; 28AB633BC7E4EC7D CRC64;
MASPICTPAA TSTPAAASSS GGRSSRSAGR RSGAAAGLSA SSTSPSRLSR MQEKDELRGL
NDRLANYIQR VQELESERSY MLLKLEEKEE ARSSVRRLYE EELADVRKSL DGLAQERAQL
QIDYGNLCEE HRTLQARNQK KEGDLTNALA QLRRAEETLS LKDAEFTKLQ SENRRLNGNL
ADLQSQLEQL EALLAETKNQ LSSEMLRRVE TENQAQTLKE ELELHKNISE QEILEIRSRH
ESRLVEVDSG QRREFESKLA EAMQQLRQDS ESQLQQYKEE IDRVFSSKLH NAQQDALEKN
DVASATKDEL DATKVRVETL SSQLQQCRKE KISLENRFQD LERTLDKERE VWHHKLSQKE
QELLNMRTQM FSQLEDYEHL MDVKVALDME ISAYRKMLEV EEQRFKLSPS PSQRTSIPRT
HEHSSRKPRG KKRKYEGESG SSPAYKMSSR SMERGAVSVA EIDVDGKYVR LKNNSEKEQS
LGGWVVRRVY PGAGDITFHI PASCVLAGGQ TLTIWAAGAE VEADPSDLVL QGHRSWGVIT
DVRVILLNSS HEEVAERRLC MLGGGEDDTG LEFDEEFVTG SEMQRFQRQP KRKKKCCSVS
//
