ID I3J6D2_ORENI Unreviewed; 1442 AA.
AC I3J6D2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Zinc finger protein 536 {ECO:0000313|Ensembl:ENSONIP00000004422.2};
GN Name=ZNF536 {ECO:0000313|Ensembl:ENSONIP00000004422.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000004422.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000004422.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR STRING; 8128.ENSONIP00000053293; -.
DR Ensembl; ENSONIT00000004424.2; ENSONIP00000004422.2; ENSONIG00000003511.2.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000156397; -.
DR HOGENOM; CLU_008125_0_0_1; -.
DR TreeFam; TF332241; -.
DR Proteomes; UP000005207; Linkage group LG1.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 7.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR45925; ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR45925:SF2; ZINC FINGER PROTEIN 536; 1.
DR Pfam; PF00096; zf-C2H2; 4.
DR Pfam; PF16606; zf-C2H2_assoc; 1.
DR Pfam; PF13909; zf-H2C2_5; 1.
DR SMART; SM00355; ZnF_C2H2; 10.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1442
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025359468"
FT DOMAIN 152..179
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 180..202
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 305..333
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 377..404
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 405..432
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 692..719
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 788..815
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 243..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 617..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 730..793
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 809..845
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 881..911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 961..1014
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1072..1127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1166..1293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1413..1442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..638
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 738..782
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 884..898
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 976..1001
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1084..1101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1103..1117
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1206..1220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1229..1249
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1259..1293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1442 AA; 157066 MW; 4CF622106C309D1F CRC64;
MSKMFLIRFL FFCFFRMEDS SLCLGVSSAV PDAEAHLSNA VLNGRYPISQ KLHQLTAQLG
HAFPDLHRPQ QIPEEKAATP LDEKTHHAAL ASQPISSQMA LLANQLNRDI DAGALSGLNG
RVDLQQFLNG QNLGIMSQMN DIEDDARKNR KYPCPLCGKR FRFNSILSLH MRTHTGEKPF
KCPYCDHRAA QKGNLKIHLR THKLGNLGKG RGRVREENRL LHELEERAIL RDKQMRGSGS
LLQTAQTPHL GPNSSSNTHQ QQLGSACTPT HSSGLATPDT VSQPSSSPKP AGAQDDQSLN
PTVGFRCTFC KGKFKKREEL DRHIRILHKP YKCTLCEFAA SHEEELISHV EKAHITAETT
QGQGSGGAGG MQMATEFRCE VCGQVFSQAW FLKGHMRKHK ESFEHCCQIC GRRFKEPWFL
KNHMKVHLNK LAIKSKPPQP SEQDMAAVNS MSNLAQEAHA NLYSRYISCL QGGFLSPDKQ
GLSEQHQMLA KAGIAMKEKE MLGKLLGPMA GAIGHGLGEN EKRSLLGCLN LVPPLKSSCM
ERLQAAAKVA EMDSINSYQA WQIMARGMAM DRAFMPKEQQ QQQHQHHITP GQEDEMAGAG
SLASFSKEKQ DYSLIASGDS SKQKQLSEAL QGSKASSGAV MSMKEDGRGF DGHRDLMSHH
GSAEAPGALA GLGSPNIDYS LSGLSGLKEK PSECPDCGRV FRTYHQMVVH SRIHGKDRRG
IDEALQQGLD ERRGSASDPE SQSISRSTTP GSSNVTEESG VGGGHSQTGS IQDDSPHPSS
PSSGEKPYRC PHCDYAGTQS ASLKYHLERH HRERQNGSAT SGSSSGHTPS SDHKEDHGKT
GGGIFARPDV LRNVFKSMPP NLDFRAGPLL PHQWASAPIV SSHNRDRDCG DRRFDSASSA
ENTKTADGPS TIVSAAADGA ASFSDLSRAY QSMMGNGVHF QGSLQAFMDN FVLSSMKKDV
KDSQSPVQLQ AQRYHDNGEP KAKRAISGEQ DREEKPEPKQ NSEPGKPGSQ YEPLDLSVSV
RPESASGSLP GTSVTIHDNV AWHGCLFCSF STSSLELMAL HLQANHLGKA PLQHADTGKD
AHREGSPTTS TLHSSNTKAS GVAPDRDGDR DGEKSQGGWN NHMEQPYNPF QSEFYRRFGG
LYDGSPRVNQ GIQGYISQAD HGLDLPSQVF GGASSAGPDQ MGDRGSCGDA EDDQVGSEDE
AGKTGVRSTN ETPSTTPKRQ QQNHSDEDEE GGVAEEEEER DEDGQMDVDR EEEGSPKQLQ
DDSSLPPRSG AAMATPSSVM TPLSLVPPPQ NQTLPLEKQW QQGLGLLTPG GPPGLLKAEQ
QTHLEQQMNM LSVLRAYSND SLPAFNGLGG GAGGAPPGGM KRSDAPGRRP FRCSYCPYSA
SQKGNLKTHV LCVHRMPFDN SCYPDRRFKR SCPDRDALEN SSDDVTSNNP MTGVDRVTRE
RE
//
