ID I3J6E1_ORENI Unreviewed; 666 AA.
AC I3J6E1;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Carboxypeptidase Z {ECO:0000313|Ensembl:ENSONIP00000004431.2};
GN Name=CPZ {ECO:0000313|Ensembl:ENSONIP00000004431.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000004431.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000004431.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M14 family.
CC {ECO:0000256|ARBA:ARBA00005988}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR RefSeq; XP_013128452.1; XM_013272998.2.
DR AlphaFoldDB; I3J6E1; -.
DR STRING; 8128.ENSONIP00000004431; -.
DR Ensembl; ENSONIT00000004433.2; ENSONIP00000004431.2; ENSONIG00000003519.2.
DR GeneID; 100701648; -.
DR CTD; 8532; -.
DR eggNOG; KOG2649; Eukaryota.
DR GeneTree; ENSGT00940000156391; -.
DR HOGENOM; CLU_006722_5_1_1; -.
DR InParanoid; I3J6E1; -.
DR OMA; VEAWPNK; -.
DR OrthoDB; 5490979at2759; -.
DR TreeFam; TF315592; -.
DR Proteomes; UP000005207; Linkage group LG6.
DR GO; GO:0004181; F:metallocarboxypeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd11308; Peptidase_M14NE-CP-C_like; 1.
DR Gene3D; 2.60.40.1120; Carboxypeptidase-like, regulatory domain; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR000834; Peptidase_M14.
DR PANTHER; PTHR11532:SF63; CARBOXYPEPTIDASE Z; 1.
DR PANTHER; PTHR11532; PROTEASE M14 CARBOXYPEPTIDASE; 1.
DR Pfam; PF13620; CarboxypepD_reg; 1.
DR Pfam; PF01392; Fz; 1.
DR Pfam; PF00246; Peptidase_M14; 1.
DR PRINTS; PR00765; CRBOXYPTASEA.
DR SMART; SM00063; FRI; 1.
DR SMART; SM00631; Zn_pept; 1.
DR SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR PROSITE; PS00132; CARBOXYPEPT_ZN_1; 1.
DR PROSITE; PS00133; CARBOXYPEPT_ZN_2; 1.
DR PROSITE; PS50038; FZ; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090}; Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..666
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025577273"
FT DOMAIN 40..162
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DISULFID 124..148
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 666 AA; 75958 MW; 21B4E9CEF1FD4D34 CRC64;
MQLGLLVMFL FWAKTSLCVP QQSCHPGDEY LGRCSNSAYE EKPKCTELNL GYCNDLEYSR
TIFPNILGHR TRLEAESGAE YLLLSVIHGL LNGECSPEIR LVGCSVLASP CRDDKMVKPC
RSTCEALRKD CIHALEAIEM AWPYFLDCDR FFASDQEGCF DPLAGLKARQ EQALSSLSPQ
EPSTIIQFTY TSNAQMYSIL KRTAAKCSHI SHVYSIGRST EGRDLLVIEF TNNPGHHELL
EPEVKLVGNM HGNEVLGRQL LIYLAQYLCS EYILGNQRIQ TIINTTRIHI LASMNPDGYE
LAASEVEDNN DPELINHEGH LLNGWTNGRT NAQNIDLNRN FPDLTSILYR NRRSRHYRTD
HIPIPDAYWF GKVAPETYAV MKWVRSLPFV QSASLHGGDL VISYPFDYSR HPHEERMFSP
TPDEQVFKQL ARTYADAHAT MSNNDTERCG ASFYRTRGII NGALWYSFAG GMSDFNYLHT
NCLEITVELG CDKFPSEAEL YPEWKRNKEA LLSFLESVHR GIKGIVKDVN DNGIKDATIS
IRGVRKDVTT AEEGDYWRLL NPGTHIVTAT AKGYSKVTKR VYLPHTMRKA GRVDFVLQKV
PVEPDIDDHL FPTADTWDRF DPYNQFEQYR DPDVGDSGRE REEKPWWWNY FSQSGISPPT
WLLRNV
//
