ID I3J6N2_ORENI Unreviewed; 1445 AA.
AC I3J6N2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Tonsoku-like protein {ECO:0000256|ARBA:ARBA00017829};
DE AltName: Full=NF-kappa-B inhibitor-like protein 2 {ECO:0000256|ARBA:ARBA00033240};
DE AltName: Full=Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2 {ECO:0000256|ARBA:ARBA00030801};
GN Name=LOC100695591 {ECO:0000313|Ensembl:ENSONIP00000004522.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000004522.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000004522.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC -!- SIMILARITY: Belongs to the Tonsoku family.
CC {ECO:0000256|ARBA:ARBA00010999}.
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DR RefSeq; XP_019204589.1; XM_019349044.1.
DR STRING; 8128.ENSONIP00000004522; -.
DR Ensembl; ENSONIT00000004524.2; ENSONIP00000004522.2; ENSONIG00000003595.2.
DR GeneID; 100695591; -.
DR KEGG; onl:100695591; -.
DR CTD; 4796; -.
DR eggNOG; KOG0504; Eukaryota.
DR eggNOG; KOG4308; Eukaryota.
DR GeneTree; ENSGT00940000160188; -.
DR HOGENOM; CLU_002128_0_0_1; -.
DR InParanoid; I3J6N2; -.
DR OMA; FLESECC; -.
DR OrthoDB; 2663363at2759; -.
DR TreeFam; TF326440; -.
DR Proteomes; UP000005207; Linkage group LG19.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR46358; TONSOKU-LIKE PROTEIN; 1.
DR PANTHER; PTHR46358:SF1; TONSOKU-LIKE PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF13424; TPR_12; 1.
DR Pfam; PF13176; TPR_7; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00368; LRR_RI; 3.
DR SMART; SM00028; TPR; 6.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF48452; TPR-like; 3.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 354..387
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 524..556
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 557..589
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 593..625
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 462..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 690..808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 871..987
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..499
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..712
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 722..736
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..759
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 790..808
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 871..885
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 886..934
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 947..961
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1445 AA; 158129 MW; 6565470FE06C4903 CRC64;
MSVSREIKQL QKAKSKAQSS NNLKEEANIC NQLGELLSRS GDYQAAIREH QQELGLSEVL
NDVIGRAVAN RKIGECYAEL GNIEAALKHQ RLHLELARSV RDHAEEQRAL ATIGRTYLFR
YESDQSRKSL EQAEEAFRKS LGIVDDRLEG TVPQREINEM KARLFLNLGL VCDHLGEHKS
CSEFIRRSVF IAEKSQLLED LYRANFNLGN IYFRNGQHSN SVRCLEQAKE CARKIKDKFS
ESECFHCIGK VQLSLGDFVA ARRSLKKAVF LGSQQPLDRQ TVKKAFKYAD QGCKLEEELG
EDQGKKPSSH QAVGLAEQLG DLCCKVGCYS KALEAYQAQL KGAEALGKPA RELAVIHVSL
AATYADLKQH SKAVEHYRKE LALRQGSSTE ECSTWLNIAA AQEESGCALE DVERSYNTAL
RCAQESGQAR LQKRVLRLWL ASQRRSGSSD ADDTEARLQE LCASEGWNPD GSDGEEEEEE
EMDNSEPLDD SDVILSDSDD DLEGYDKMVS GRRKTGRWNK RNEKGETSLH RACIDGNLKQ
VQYLVEQGHP VNPRDYCGWT PLHEACNHGH YDIVALLLEH GANVNDPGGP YCEGVTPLHD
AVACGNLEVA GLLVERGASV TLRNSKGETA LDTLRQWQRT YSRELDHETR QKCIATERLL
RKALAGGVPA APAPAKPFDA LQDSQLFDAE SSEPLSSTGG GSFSSQDWPR SRSPEVKASA
ASPKRRQTNG STQRHRARGT EAAVLYGINS SSSDDSEPET PVSPLRPVRP RQGFPAAQSQ
KEPPANKEAA SVPTSGQEGI RQASTQSVFA REEYHSAIRG LGSAKTLLQG LSQPQLSSTP
AVSSSNKSAL VPEDEYLADD WLEDDLVETQ PKKKRRLRTE QDGPRVEETA SSSAARSQNK
HLNSDTACRG SAASSLSSRG LSQRTNTSRK PHQVKMTQIP GVARLGRREV NRSHGPTVTD
DDDSRSGTPP PPLIIHTQPP TQTLVAPMPT SLPPPIRMRV RVQEDVFLIP VPQSEANSCT
VSWLCEQAAQ RYYQKCGLLP RLSLQKEGAL LSPQDQLLAV LHTNEEVLAE VCSWDLPPLP
ERYKKACQSL AVDENKRVFR LCEVQDRGSS VSVCGLGLAA SSLGPLLRAL KLQASLTELR
ISGNRMSDDL LPELIATTLT MPRLQLLDIS ANCITGDGLE KAVNALKGQS APAFPCLEEL
DLSMNPLGDG VSESLSCLLS CCPVLAKLSL QACGLTARFL QQHRLLLASA LTGTGHLKSV
CLSHNALGST GFELVLKTLP LHCLTHVDLS AVCRGPADYP ALEHLAKVLS QDECSLTHLS
LAANGLTDSS VATLARCLLS CPTLVSLNLS GNPSLTSAGL HNILASVRVT RRPLTLLNLE
GCQVSGPWES EDLDSLSELV QDIRLCSQAL NKLDRQALKQ SWDRTQSHGH FLDRNSKCLL
SATST
//
