ID I3J6T9_ORENI Unreviewed; 1258 AA.
AC I3J6T9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Unconventional myosin-VI {ECO:0000256|ARBA:ARBA00015382};
DE AltName: Full=Unconventional myosin-6 {ECO:0000256|ARBA:ARBA00030027};
GN Name=LOC100711408 {ECO:0000313|Ensembl:ENSONIP00000004579.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000004579.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000004579.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, filopodium
CC {ECO:0000256|ARBA:ARBA00004486}. Cell projection, microvillus
CC {ECO:0000256|ARBA:ARBA00004105}. Cell projection, ruffle membrane
CC {ECO:0000256|ARBA:ARBA00004632}. Cytoplasmic vesicle, clathrin-coated
CC vesicle {ECO:0000256|ARBA:ARBA00004132}. Golgi apparatus, trans-Golgi
CC network membrane {ECO:0000256|ARBA:ARBA00004150}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004150}. Membrane, clathrin-coated pit
CC {ECO:0000256|ARBA:ARBA00004600}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR AlphaFoldDB; I3J6T9; -.
DR Ensembl; ENSONIT00000004581.2; ENSONIP00000004579.2; ENSONIG00000003639.2.
DR GeneTree; ENSGT00940000156078; -.
DR HOGENOM; CLU_000192_7_2_1; -.
DR Proteomes; UP000005207; Linkage group LG19.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0005902; C:microvillus; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0007605; P:sensory perception of sound; IEA:UniProtKB-KW.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd21759; CBD_MYO6-like; 1.
DR CDD; cd22294; MYO6_MIU_linker; 1.
DR CDD; cd01382; MYSc_Myo6; 1.
DR CDD; cd21958; MyUb_Myo6; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 6.10.220.10; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR049016; MYO6_lever.
DR InterPro; IPR032412; Myosin-VI_CBD.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR036114; MYSc_Myo6.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF745; UNCONVENTIONAL MYOSIN-VI; 1.
DR Pfam; PF21521; MYO6_lever; 1.
DR Pfam; PF16521; Myosin-VI_CBD; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coated pit {ECO:0000256|ARBA:ARBA00023176};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hearing {ECO:0000256|ARBA:ARBA00022740};
KW Membrane {ECO:0000256|ARBA:ARBA00023176};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 2..53
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 57..770
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 650..672
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT COILED 863..1017
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 151..158
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1258 AA; 144729 MW; 09B31A0C56226423 CRC64;
MEDGKPVWAP HPTDGFQLGT ITDIGADTLT IEPLNQKGKT FLAPMNQVFP AEDDVNKHVD
DNCSLMYLNE ATLLNNVRVR YSKDHIYTYV ANILIAVNPY FDIPKLYGPD AIKSYQGKSL
GTLPPHVYAI ADKTYRDMKV LKMSQSIIVS GESGAGKTEN TKFVLRYLTT SYGSGQDIDE
RIVEANPLLE AFGNAKTVRN NNSSRFGKFV EIHFNSKNAV VGGFVSHYLL EKSRICMQSN
EERNYHIFYR LCAGASEDLK KKLHLDSPDN FRYLNRGCTR YFASKDSDKQ IMQNRKSPEH
VKTGALKDPL LDDHGDFNRM CEAMKKIGLN DTEKLDLFRV VAGVLHLGNI DFEETGSSSG
GCVLKNQCND SLQYCADLLG LDQDDLRVSL TTRVMLTTAG GAKGTVIKVP LKVEQANNAR
DALAKAVYSR LFDHVVKRVN QCFPFETSSN FIGVLDIAGF EYFEHNSFEQ FCINYCNEKL
QQFFNERILK EEQELYQKEG LGVNEVHYVD NQDCIDLVEA KLTGILDILD EENRLPQASD
QHFAQAVHSK HKDHFRLTVP RKSKLTVHRT LRDDEGFIIR HFAGAVCYET IRFVEKNNDA
LHMSLESLVC ESKDKFVREL FENSNTSKDS KQKAGKLSFI SVGNKFKTQL NLLLEKLRST
GSSFIRCVKP NLKMVSHQFE GALILSQLQC SGMVSVLDLM QGGFPSRAPF HELYNMYKQY
MPDKLTRLNP RLFCKALFKA LGLNDKDFKF GLTRVFFRPG KFAEFDQIMK SDPDHLAELL
KKVNKWLLCS LWKKVQWCCL SVIKLKNKMS YRAVACIKIQ KTVRMWLSKK KHKPRIDGMV
KVRSLKKHME RFNEVVNGLK EGKQEMAKQV QELAAAIDAL LAKIKTTVMT RKEIDTEYQG
LVKRSEQLLA SMQKKKQEEE ERERLKCIEE EMEKERKSRE QEEQRRKQEE EERRLFIDTL
GRCIKYCVTI LLCLCVCLQA ELEIQLAQER EEQAQRAAVL EQERRDRELA MRIAQNEAEL
ITDESQMDAA LRRGPQVQAT KAAAGVKKYD LSKWKYAELR DVINTSCDID LLAACREEFH
RRLKVYHAWK SKNKKQNDDG SDLRAPKCVT DYVQITAEQN PAPPMTAQHQ EVAMNRQQRY
FRIPFIRPAD QYKDPQNKKK GWWYAHFDGP WIARQMELHP DKRPIVLVAG KDDMEMCELS
LEETGLTRKR GAEILPRQFE EIWERCDGIQ YLKKAIENKQ ARPTYATAML QNLLNLMK
//
