ID I3J7P3_ORENI Unreviewed; 605 AA.
AC I3J7P3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Solute carrier family 23 member 2 {ECO:0000313|Ensembl:ENSONIP00000004883.1};
GN Name=LOC100696193 {ECO:0000313|Ensembl:ENSONIP00000004883.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000004883.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000004883.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_005454237.1; XM_005454180.3.
DR AlphaFoldDB; I3J7P3; -.
DR STRING; 8128.ENSONIP00000004883; -.
DR Ensembl; ENSONIT00000004886.2; ENSONIP00000004883.1; ENSONIG00000003875.2.
DR GeneID; 100696193; -.
DR KEGG; onl:100696193; -.
DR eggNOG; KOG1292; Eukaryota.
DR GeneTree; ENSGT00950000182953; -.
DR HOGENOM; CLU_017959_5_4_1; -.
DR InParanoid; I3J7P3; -.
DR OMA; LPFFGCQ; -.
DR OrthoDB; 911690at2759; -.
DR TreeFam; TF313272; -.
DR Proteomes; UP000005207; Linkage group LG7.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR InterPro; IPR006043; NCS2.
DR InterPro; IPR006042; Xan_ur_permease.
DR PANTHER; PTHR11119:SF86; SOLUTE CARRIER FAMILY 23 MEMBER 2-LIKE; 1.
DR PANTHER; PTHR11119; XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
DR PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 65..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 107..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 284..307
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 344..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 431..454
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 460..479
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 491..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 524..544
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 605 AA; 65928 MW; 24A23BEA7000FA36 CRC64;
MHLTTEETIE LGLHDQGTDN PAFGDKDDEQ PQLTADPGES HTEETLEGTT GKKIDLVYSL
NDRPPWYLCI LLGFQHYILA FGGIIAVPLI LAEPLCIKDN NIAKSQLIST IFFVSGLCTL
LQTTVGNRLP ILQGGTFSFI TPTLAILALP KWQCPVPNAP VKLLVQFHNG TSPLQMENSD
EVWMTRMREI QGAILVSSLL QLTLGLSGLV GLVLRYIGPL AIAPTINLIG LSLFTEAGKK
SGGHWGIAAL TVGLILLFSQ YLSNVDVPMV AYKNKKWMVF QYPLFKLFSV LFGMCGGWLI
CFLLTIFDVL PSKSDTYGFS ARTDINLDAV TNSPWFHVPY PGQWGVPTVS LSSVLGMMAG
VLASTMESIG DYYACARLSG APPPPIHAVN RGIAVEGIGC ILAALWGTGN GTTSYSQNIA
ALGITKVGSR LVLQTTGILM IILGIFGKFG AIFITIPDPV IGGMFLIMFG MIAAVGISNL
QYVDLNSSRN LVILGFSTFS GLVLPTWFQS NPGIIDTGIK ELDQLIVVLF TTHMFIGGFF
GFILDNTIPG TDKERGIKNW QDKVQDGSEN MHDQSCYDIP FCNRVLKRFR CFQCLPFLPS
YKTTQ
//