ID I3J800_ORENI Unreviewed; 1170 AA.
AC I3J800;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Bromodomain containing 1b {ECO:0000313|Ensembl:ENSONIP00000004990.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000004990.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000004990.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; I3J800; -.
DR STRING; 8128.ENSONIP00000004991; -.
DR Ensembl; ENSONIT00000004993.2; ENSONIP00000004990.2; ENSONIG00000003960.2.
DR eggNOG; KOG0955; Eukaryota.
DR GeneTree; ENSGT00940000157236; -.
DR HOGENOM; CLU_003589_1_0_1; -.
DR TreeFam; TF316118; -.
DR Proteomes; UP000005207; Linkage group LG7.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15572; PHD_BRPF; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR019542; Enhancer_polycomb-like_N.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR000313; PWWP_dom.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13793:SF17; BROMODOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR13793; PHD FINGER PROTEINS; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF10513; EPL1; 1.
DR Pfam; PF13831; PHD_2; 1.
DR Pfam; PF00855; PWWP; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00249; PHD; 2.
DR SMART; SM00293; PWWP; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS50812; PWWP; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 215..265
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 269..391
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 574..644
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 1042..1125
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 93..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 406..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 749..775
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 787..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 871..900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 917..941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 510..553
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 413..429
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 441..455
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 829..846
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 871..894
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 917..936
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1170 AA; 132901 MW; 58B3B70315A7EA46 CRC64;
MKKKSRNQRP AVIKRETSPI KPSPNRETLT YAQAQRMVEL EVDGRVHRLS IYDKLDVITD
DDPTAQEIME CNSNKENNEK PQQVLVRSVR LKNNQQKKNA ALTTSHGGSA THSSTSGLLE
PKVRTVEYNL PVVPKRPATY YKYTERTPEE LDEEVEYDMD EEDYAWMEII NEKRKSEGIS
QVSHNLFEFL MDRFEKESFL ATQGQSDLQS LVDEDAVCCI CMDGDGADSN VILFCDSCNI
AVHQECYGVP YIPEGQWLCR HCLQCPTRPA ECVFCPNRGG ALKKTDDDRW GHVACALWVP
EVGFSDTVFI EPIDGVRNIP PARWKLTCYL CKEKGVGACI QCDKINCYTA FHVSCAQKAG
LCMKMEPVKE VTASGATTFS VKKTAYCCSH TPEGCDRRPL NIYEEPHPKN GAFHKRAEKK
GKAKGWQKKK NKRADPEPET EPETPTSSGP SITASSFDTI LNQVSVQRKR SFVEGVLSYW
VLKRQSRNNV PLIRRLQANP QPPKDHMESN QALKEQLKEW HRLRHDLERA RLLLELIRKR
EKLKREEMKL QQSVLEVQLT PFNILLRAVL SQLQEKDQYS IFAQPVSVKE VPDYLDIIKN
PMDFSTMRKR IDAHFYRSLE GFEADFDLII SNCMTYNAKD TFFYKAAQRM QDHGGAILRR
ARREAERIGF DFPSGLHLPE VPKLEPTPPF TWEDVDRLLT PTYRQKTPLE DQLKELLEKL
DLSIAMKHSP SRSKRLKLLK KTITEVRSEI SLKNSLPPQP STPDPSPSPA ESEDQPLREL
LADPSMTQED KSLPPPPLET LTLPSQILPM DLDPTPVKLT KPLDQTPAEL EDVTNTSTSV
PSDTPNGHIP ESLLPKSDLY VERYNRRTNV LFRKSKSASP QKPPRTQEVS SGSPPPLGAK
TFLSVVIPRL ETLLLPKKRK RSSSADGEDD EESPIKRLGT GMANGFVVEE EGVVSQSPRL
LEPRRRCASE SSISSSGSIL CDTRTVILSK SGKGRPATAR RSTVDDKSTL MTCIENGEFI
KAAKISSEVW KPTAASPFVL EPLKLVWAKC SGYPSFPALI MDPRSRKTMC RHSGVDLPQP
PLDVLRAGER MQFRSAEKLF LVHFFDSRRS WQWLPRSKMA PFGINKMLDR MKLMEARSSS
VRKSVRLAFD RAMKHLDRIR ELDQFWYTAF
//
