GenomeNet

Database: UniProt
Entry: I3J845_ORENI
LinkDB: I3J845_ORENI
Original site: I3J845_ORENI 
ID   I3J845_ORENI            Unreviewed;       710 AA.
AC   I3J845;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   08-NOV-2023, entry version 73.
DE   SubName: Full=RAS guanyl releasing protein 4 {ECO:0000313|Ensembl:ENSONIP00000005035.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000005035.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000005035.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the RASGRP family.
CC       {ECO:0000256|ARBA:ARBA00009566}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; I3J845; -.
DR   STRING; 8128.ENSONIP00000005035; -.
DR   Ensembl; ENSONIT00000005039.2; ENSONIP00000005035.2; ENSONIG00000003995.2.
DR   eggNOG; KOG3417; Eukaryota.
DR   GeneTree; ENSGT00940000159883; -.
DR   HOGENOM; CLU_019261_0_0_1; -.
DR   InParanoid; I3J845; -.
DR   OMA; RHTPQQR; -.
DR   TreeFam; TF312918; -.
DR   Proteomes; UP000005207; Linkage group LG14.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0048468; P:cell development; IEA:UniProt.
DR   GO; GO:0001945; P:lymph vessel development; IEA:Ensembl.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   Gene3D; 3.30.60.20; -; 1.
DR   Gene3D; 1.10.238.10; EF-hand; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR046349; C1-like_sf.
DR   InterPro; IPR020454; DAG/PE-bd.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF157; RAS GUANYL-RELEASING PROTEIN 4; 1.
DR   Pfam; PF00130; C1_1; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   PRINTS; PR00008; DAGPEDOMAIN.
DR   SMART; SM00109; C1; 1.
DR   SMART; SM00054; EFh; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR   SUPFAM; SSF47473; EF-hand; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          52..183
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          207..438
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   DOMAIN          472..507
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   DOMAIN          545..595
FT                   /note="Phorbol-ester/DAG-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50081"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          34..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          631..681
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        37..55
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        631..645
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        646..665
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   710 AA;  80505 MW;  1A2B1C5A17693761 CRC64;
     KPIKTTSYKV SKSTGSNVES PGVLKGKKLV HRRRNTCPSP QDITRALQSP SSAPSASAAS
     LDDLIQRCLN CFDSEGKTSS PRGTQLVHMT LMMHSWVVPS EAFAQKLLTL YPPLPLSDCP
     SDKRGLRRTQ IRHLARQWIS QFPAVFEVDP HLEQTMGDLW ALVRSDGEEK HSQLIENSCL
     SPHLNISQAP SPSVKKRKVS LIFDHMEPDE MAEHLSYLEF KNFCNVSFLD YRSYVVRGSV
     RDNPALERSV MMCNGVSQWV QLMILSRHTA QQRAQVFTKF IHVAQKLRSL QNFNTLMAVT
     GGLCHSSISR LKDTSNLLPP DVTKALSEMT ELLSSRSNYS NYRRVYNECT GFKVPILGVH
     LKDLISLNEA LPDYIDEEKI NLSKLQHLYS NINDLLALHS CTPPFEANKD LLHLLTLSLD
     LYYTEDEIYE LSYAKEPKNP KVQPVAPVKP PVVAEWGSGV TPRLDPDTIS KHVKQMVDSI
     MKNYDHNQDG YISLEEFEKI AANFPFSFCT QETDREGQIS REEITSYFMR GMSVCAKLGY
     NFNDAHNFHE TTYKRPTFCD ICRGFLWGVT KQGYHCKDCG INCHRHCRDL VGIECLKKHK
     NTTGSCPCTP APDLRTKGNS WSSEEETFVF PPSNETEHHK GTLDWKSNTS ESVLSDRSTQ
     TDPGIWTPEK KDKKGNHLHS RPSLRKLLPD TVQNDNSIKN TVSLDMYNFK
//
DBGET integrated database retrieval system