ID I3J895_ORENI Unreviewed; 791 AA.
AC I3J895;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase {ECO:0000313|Ensembl:ENSONIP00000005085.1};
GN Name=H6PD {ECO:0000313|Ensembl:ENSONIP00000005085.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000005085.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000005085.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway.
CC {ECO:0000256|ARBA:ARBA00004959}.
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DR RefSeq; XP_005453564.1; XM_005453507.3.
DR RefSeq; XP_005453566.1; XM_005453509.2.
DR RefSeq; XP_005453567.1; XM_005453510.3.
DR RefSeq; XP_019214781.1; XM_019359236.1.
DR RefSeq; XP_019214782.1; XM_019359237.1.
DR AlphaFoldDB; I3J895; -.
DR STRING; 8128.ENSONIP00000005085; -.
DR Ensembl; ENSONIT00000005089.2; ENSONIP00000005085.1; ENSONIG00000004034.2.
DR GeneID; 100705236; -.
DR KEGG; onl:100705236; -.
DR CTD; 9563; -.
DR eggNOG; KOG0563; Eukaryota.
DR eggNOG; KOG3147; Eukaryota.
DR GeneTree; ENSGT00530000063435; -.
DR HOGENOM; CLU_018975_0_0_1; -.
DR InParanoid; I3J895; -.
DR OMA; YCPQSGT; -.
DR OrthoDB; 989808at2759; -.
DR TreeFam; TF354247; -.
DR UniPathway; UPA00115; -.
DR Proteomes; UP000005207; Linkage group LG5.
DR GO; GO:0017057; F:6-phosphogluconolactonase activity; IEA:InterPro.
DR GO; GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniPathway.
DR CDD; cd01400; 6PGL; 1.
DR Gene3D; 3.40.50.1360; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR005900; 6-phosphogluconolactonase_DevB.
DR InterPro; IPR001282; G6P_DH.
DR InterPro; IPR019796; G6P_DH_AS.
DR InterPro; IPR022675; G6P_DH_C.
DR InterPro; IPR022674; G6P_DH_NAD-bd.
DR InterPro; IPR006148; Glc/Gal-6P_isomerase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR NCBIfam; TIGR01198; pgl; 1.
DR PANTHER; PTHR23429:SF7; GDH_6PGL ENDOPLASMIC BIFUNCTIONAL PROTEIN; 1.
DR PANTHER; PTHR23429; GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD; 1.
DR Pfam; PF02781; G6PD_C; 1.
DR Pfam; PF00479; G6PD_N; 1.
DR Pfam; PF01182; Glucosamine_iso; 1.
DR PRINTS; PR00079; G6PDHDRGNASE.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
DR PROSITE; PS00069; G6P_DEHYDROGENASE; 1.
PE 4: Predicted;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00022526};
KW Glucose metabolism {ECO:0000256|ARBA:ARBA00022526};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..791
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003672380"
FT DOMAIN 34..216
FT /note="Glucose-6-phosphate dehydrogenase NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF00479"
FT DOMAIN 221..517
FT /note="Glucose-6-phosphate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02781"
FT DOMAIN 560..782
FT /note="Glucosamine/galactosamine-6-phosphate isomerase"
FT /evidence="ECO:0000259|Pfam:PF01182"
FT BINDING 213
FT /ligand="substrate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10005"
SQ SEQUENCE 791 AA; 89309 MW; 1042A8AA24E0BEEF CRC64;
MFLTVFFLLV ALCTQGGNGK ESEEAQRPGH VSVVIVGGTG DLAKKYLWQG FFQLYINQVS
SGNTFSFYGG GQSPTEKATP VLFEILKAVS CSKDVSQERC ALLKDQFLRL AQYRQLKSLE
DYQDLAKHIE QQLQEEGMTE AGRLFYLSVP AFAYADIAEK INSSCRPKSG AWLRVVLEKP
FGHDYRSAQV LASQLRSSLT EEEMYRIDHY LGKQVVSKIL PFRIQNKNLL DPIWNKHHIE
RVEIVLKETL DVKGRIAFYD QYGVIRDVLQ NHLTEVMTLL TMRLPKNVSR SEEVLGNKLQ
ILSSMLPLGK NQAVIGQYQT YKAEVQQELN KTKDHVSHTP TFAAVLAQID DAQYEGMPIL
LISGKMLDER VGYARILFKN DIFCVQNHNN VHCKPKQIVF YFGHGSLQYP AILVSKNLFK
PALVDSEWKE VTEHKDINVF GLPISDFYIQ TPMEQKEAYA ELISHIFFGR KNSFISTENL
LASWDLWTPL LSSLASTFPR IYPGGADNAD VLDIHLKGKD ISYNNEVVII STDQLGGTST
NGFQVMQGKF RSSEMVSAWA EQLVDKLAAD IQEAAEAAIY EGGVFHLALS GGSTPLALFH
RLVDHHFTFP WRNTHVWMVD ERCVLPTELE SNFRSLHDHL LQHVRIPYYN IHPMPVHLNQ
RLCVEEDGGA QMYEKQLIKL VNSSSFHFVL LGVGYDGHTA SLFPGGKVDE LGDSLVALTE
SPSKPHQRMS LTFNVINRAR KVALLVMGKG KHELITQLSR VKDNPDKWPV TGVKPTNGNL
VWYIDYDALL G
//
