ID I3J8E6_ORENI Unreviewed; 2222 AA.
AC I3J8E6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Laminin G domain-containing protein {ECO:0000259|PROSITE:PS50025};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000005136.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000005136.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR STRING; 8128.ENSONIP00000005136; -.
DR Ensembl; ENSONIT00000005140.2; ENSONIP00000005136.2; ENSONIG00000004075.2.
DR eggNOG; KOG3597; Eukaryota.
DR GeneTree; ENSGT00940000154091; -.
DR HOGENOM; CLU_000473_1_0_1; -.
DR InParanoid; I3J8E6; -.
DR TreeFam; TF316876; -.
DR Proteomes; UP000005207; Linkage group LG7.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00110; LamG; 2.
DR Gene3D; 2.60.120.200; -; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR45739:SF8; TNFR-CYS DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF16184; Cadherin_3; 11.
DR Pfam; PF02210; Laminin_G_2; 2.
DR SMART; SM00282; LamG; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR PROSITE; PS51854; CSPG; 8.
DR PROSITE; PS50025; LAM_G_DOMAIN; 2.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2070..2093
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 13..188
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 198..382
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REPEAT 521..615
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 623..722
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 855..949
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 981..1073
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1089..1188
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1372..1462
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1708..1800
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1794..1883
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REGION 1991..2054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2176..2222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1991..2009
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2182..2222
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2222 AA; 246341 MW; B23827B659B59758 CRC64;
IKTSKNKNVK NPGISLENMN DGYIYLRTVE TSIQTLIHVR FRTSSQSGLL FLAAGHTDFM
LLELISGYLQ VRIDLGSGEH SLRSEKGIHL SDLAWHTVDL THTRHNITIT VDRNSHTGLQ
IQEPDPELGV EDGLLVGGTA GLKHLYLHNI SSGFRGCMDE VVFNQHNLLS SLRPHSGYKT
VHEVSLGCSP QFSATEEDPV SFFSSKAFMS LPPWDVLQEG VFECELYPAA KEEEDGIVLY
SSDNQGGFVA IEIIRGHLVA SVGGGEGSKT ELHSLTNVNS NHTWYTIQLH LLPHSVQLKV
GKELVKASLS PEIQVIQLKG PLFLGGLDEA ARGEARQAGL ISVPSGGEGG GSFKGCLREI
RVNTQKTGLP HATVTKDVTV GCKTGQAPQR AILTSPTDLP AVDITTTQTN AKRSPNFLML
RKLEVSEGGR APLEPKHIKV VLICLLSLPV HGQLRLDLRI EEKDRTFSML DLWQGRVMYV
HGGSEDQNDF FTFSVFSSNK KELPVFLKGN RLHRFEISIS PVNDAPVLSL SKLMHSQFPQ
LTTDVLRVLD PDSSPEELVF SSLGNLSTEA GYLEHQDYPG RPINLFSLND LEEGKISFIH
TGVSTSRLAL RVSDGQKVSK IAAYKLVNNT GLEVNQGEAS VITTNHLAVQ VNVADPTVEI
WYNVTEFPQY GELQRLHSSG EWKPATSFSQ KVLEKERIRY LSTYRGLQMQ NNITDHFKFK
VSIGSLAKQE AVFPIAVRWI HFKITRSKME LNGVQAAVLT PEDLHVISKG VKLSESDLHF
RMVTVPKKGQ LLLNNKVLQR NSTFSQRNIS DGLVRYELIN RQHDDTRDTF SFQVFSAHSN
STTYDFRINI KAESTTVTVI SKGLSVMEGG SKVITRDILF THTASNREVL YNIIESPRHG
HIRRINLSNS TSINDNIMAF TNQDITEERI MYVHDDSETK QDSFTFQIGV YKSHKHTNKK
EDGNAEEHTF NISVQLVNDQ RPVRVVDKVF HVAREGQRLV TLNDLRYRDD DSDFEDSWLV
YTRRGIPMGE LVLAGDPSHK LYEFTQRDLE QVRVLFVHRG VSFGRFVLFV SDGKHYVSTL
LEVMAQDPYL QVENNTGLMV QQGGITTLTS ANLSVFSNLD IRDPQEVTFE VFLPPKHGVI
CFIDRESGII TDADAISIFT QRDLIAGRLA YRHDGSHKLS DSFNVTARVH LDIGVSVKIY
LESHQRPPTV RNNRPVVVEE GQNISISRDN LEVIAHHIFK VFNGSLRGCS QGVCSLCPSM
QGNKKQSTPT FTQEDLNQGL VIYQQQTAGS TNDSVLLEAT NGVTKVGPIR LEIDIIPILL
PLQVEREYIS YIHDGSDTLR DNFTIVANQT ETRKHSLPCT VHINITPVND ETPVVTTNHG
LKVWVGSVTE ITTGDLSAED IDTPPEGLEF IVTPPSNGHL ALKSSPSRHI LNFTQSHIEG
KQLVFVHNGA PSGGFHFQVN DGVNFAPRQI FSTTAHSLIL TLQRNHPMEV YPGIPALPVV
TNIADGDIRR NQSVVFAVTS PPKLGRLVRR MPDNSTGNLD DGVILYDQNK PESVGWSAAD
TFSFTVSLPP AFLPPHTFTI LISYQANEHH DSPQHKTRLL NNAGAVVAEG GRVTIDRSKL
DASNLLGKIP ESRRKDHHIM YRVISFPRYG ILSIRGHNLT RYLAFGIIYF HDDSETTSDS
FTFRAWVAPL DLPSSSSSSS LSMFNITVTP VNDQPPLIRS RNFFLILHFF HVQVEDHDTP
PEELHYLVIS KPNNGYLTLG ERPEPVTSFT QYDVNHGRLH FIQQLFSLEV IKPSVSIVNN
TGLSLIQGRT AVVLTPNQLA AQTNGQSRAT VSYTVTTPPR HGRIAINDQE VTTFRHEDLQ
FGRVVYHMTD LSESEDTFQM SVSASSPGVN YGNVTATVKV TVRPLIYLRE PVRVPSGIAV
KLGKAMIDAS ELARISRANP VFEVLSPPKH GKLVKVKPLV LMSRGGQGGG RGGSTAHGEV
TVGLHPHILS HKHHNRTHHK LRPHNRLGNH TRNGSHGGRS KSSIEGAGGG HSHAPQPHTP
SIPEKHGPEN PPDTQLIHVE VLPRPASDPL LIILPLLACL LLIIILIVLI LVFRHRKEKQ
ARLRLVQELA AVPVPTEDSP YLGRPERSVA MPSVMVTPLG SASCPTSPRV PTSPRRSLAP
GMTFWGPFEA DLAGGDGNIR GCNSNERDNT TSSNPLPRTA GFRTSVRSRS PTPTLKESQY
WV
//
