ID I3J8W0_ORENI Unreviewed; 1197 AA.
AC I3J8W0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902, ECO:0000256|PIRNR:PIRNR000619};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902, ECO:0000256|PIRNR:PIRNR000619};
GN Name=ERBB4 {ECO:0000313|Ensembl:ENSONIP00000005300.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000005300.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Ensembl:ENSONIP00000005300.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. EGF receptor subfamily. {ECO:0000256|PIRNR:PIRNR000619}.
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DR AlphaFoldDB; I3J8W0; -.
DR STRING; 8128.ENSONIP00000005301; -.
DR Ensembl; ENSONIT00000005304.2; ENSONIP00000005300.2; ENSONIG00000004212.2.
DR eggNOG; KOG1025; Eukaryota.
DR GeneTree; ENSGT00940000154695; -.
DR HOGENOM; CLU_003384_1_1_1; -.
DR TreeFam; TF106002; -.
DR Proteomes; UP000005207; Unplaced.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0038127; P:ERBB signaling pathway; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0042127; P:regulation of cell population proliferation; IEA:UniProt.
DR CDD; cd00064; FU; 3.
DR CDD; cd12092; TM_ErbB4; 1.
DR Gene3D; 6.10.250.2930; -; 1.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR044912; Egfr_JX_dom.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR049328; TM_ErbB1.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
DR PANTHER; PTHR24416:SF90; RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF14843; GF_recep_IV; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01030; Recep_L_domain; 2.
DR Pfam; PF21314; TM_ErbB1; 1.
DR PIRSF; PIRSF000619; TyrPK_EGF-R; 2.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00261; FU; 5.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR000619};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR000619};
KW Membrane {ECO:0000256|PIRNR:PIRNR000619, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR000619};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR000619};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000619};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137,
KW ECO:0000256|PIRNR:PIRNR000619}.
FT TRANSMEM 627..650
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 693..960
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT ACT_SITE 818
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-1"
FT BINDING 699..707
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2"
FT BINDING 726
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2,
FT ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1197 AA; 134607 MW; D8A2F3606C8AA904 CRC64;
SWGCKVSLIC PVVCAGTENK LSTLSDLEQQ YRTLRKYYES CEVVMGNLEI TSIDRSRDLT
FLRSIREVTG YVLVALNQFD YLPLENLRII RGTKLYEDRY SLAIFLNYRR DGNFGLRQLG
LKNLTEILNG GVYVDQNKFL CHADTIHWQD IVKYPRIQPV VVPTNSSVTC QKCHRSCNGR
CWGPKEDQCQ SLTKTVCAEQ CDGRCFGPFV SDCCHRECAG GCYGPKDTDC FACTNFNDSG
ACVTQCPQPF VYNPTTFQLE HNPRAKYTYG AFCVKKCPHN FVVDHSSCVR ACPSNKMEVE
ENRIKMCIPC TDICPKACDG IGTASLQTAQ TVDSNNIDKF VNCTKINGNL VFLITGIKGD
VYHNIEALDP EKLNVFRTVR EITGFLNIQS WPDNMTDLSV FSNLATIGGR ALYSGISLLV
LKQPGITSLQ LQSLREISAG NVHIAENSQL CYYNTVNWTR LFRTTNQKVL IRNNRSPQEC
SAKEHMVCDP LCSDAGCWGP GPDQCLSCRY FSRGRTCVES CNLYEGDIRE YANGSVCVEC
DAQCERADGD SLTCLGPGPE HCVKCLHFKD GPNCVEKCPD GLQGANSFIF KYAEANNECH
PCHANCTQGC IGPRLQDCIG WMDRTPLIAA GVIGGLFMVV IMVLSVAVSV RRKNIKKKRA
LRRFLETELV EPLTPSGTAP NQAQLRILKE TELKRVKILG SGAFGTVYKG IWVPEGETVK
IPVAIKILNE ATGPKANVEF MDEALIMASM EHPHLVRLLG VCLSPTIQLV TQLMPHGCLL
DYVHEHKDNI GSQLLLNWCV QIAKGMMYLE ERRLVHRDLA ARNVLVKSPN HIKITDFGLA
RLLDVNEKEY NADGGKMPIK WMALECIHYR KFTHQSDVWS YGVTIWELMT FGGKPYDGIS
TRDIPDLLEK GERLPQPPIC TIDVYMVMVK CWMIDADSRP KFKELAAEFT RMARDPQRYL
VIQGDDRMKL PSPSDSKFFQ SLLDEEELDD LMDAEEYLVP HSFNIPPLAY TPRTRMDSNK
VLYFKRPNTM FNITVETLAN PNIPFLFPDY LIPVEENPFV TRRRNGDAHT VIDGASCHTL
HLAGATAAPK SQSTHGDDEY VNEPLYLNTL LNAGAKNGLK GKKATFDNPE YWQHSLPPKS
SLHNPEYLQD CSTRFFYRQN GRIRPAVAEN QEYLSEAAMK TGNVLPPPPY RQRNTVV
//
