ID I3J913_ORENI Unreviewed; 950 AA.
AC I3J913;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Connector enhancer of kinase suppressor of ras 2 {ECO:0000313|Ensembl:ENSONIP00000005353.2};
GN Name=CNKSR2 {ECO:0000313|Ensembl:ENSONIP00000005353.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000005353.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000005353.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CNKSR family.
CC {ECO:0000256|ARBA:ARBA00009498}.
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DR AlphaFoldDB; I3J913; -.
DR STRING; 8128.ENSONIP00000065634; -.
DR Ensembl; ENSONIT00000005357.2; ENSONIP00000005353.2; ENSONIG00000004252.2.
DR eggNOG; KOG1738; Eukaryota.
DR GeneTree; ENSGT00940000156709; -.
DR HOGENOM; CLU_013414_0_0_1; -.
DR TreeFam; TF326495; -.
DR Proteomes; UP000005207; Linkage group LG10.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01260; PH_CNK_mammalian-like; 1.
DR CDD; cd09511; SAM_CNK1_2_3-suppressor; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR049628; CNK1-3_SAM.
DR InterPro; IPR010599; CNK2/3_dom.
DR InterPro; IPR017874; CRIC_domain.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR12844; CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS; 1.
DR PANTHER; PTHR12844:SF21; CONNECTOR ENHANCER OF KINASE SUPPRESSOR OF RAS 2; 1.
DR Pfam; PF06663; CNK2_3_dom; 1.
DR Pfam; PF10534; CRIC_ras_sig; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS51290; CRIC; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 11..76
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 84..178
FT /note="CRIC"
FT /evidence="ECO:0000259|PROSITE:PS51290"
FT DOMAIN 215..297
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 561..660
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 324..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 662..761
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..380
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 667..688
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 739..757
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 950 AA; 107915 MW; 3145133B5907EE5E CRC64;
MALVMEPVSK WSSSQVVDWM KGLDDCLQQY IKTFEKEKVG GEQLLRITHQ ELEDLGVSRI
GHQELILEAV DLLCALNYGL ETENLKTLSH KLNASAKNLQ NFITGRRRSG HYDGRATRKL
PNDFLTSVVD LIAAAKSLLA WLDRSPFAAV ADYSVTRNNV IQLCLELTTI VQQDCSVYET
ENKILNVCKT LSEVCDQIIS LSSDPMVSQS AHLEVVQLAN IKSTEGLGMY IKSTYDGLHV
ITGTTEGSLA DRCKKIHAGD EVIQVNHQTV VGWQLKNLVN LLRGDPAGVT LTLKKRPQST
LTSTPALLKN MRWKPLALQP IFPQSPSSSV ATPTSTLSTP SRRSSCALQD LYIPPPPAEP
YTPRDDKGSL PDDDPQSDVH VAEGSESPNS YLDQECRRRF PLVEEDTILY CYEYDQNQEG
ASVRRGSTPT YGRLRPISMP VEYNWVGDNE DLAKLKRESR RENSLMHFES EDKTSREDFL
LGRSLSQNRR KTERGASPTH YTLVPALQME VSRSTSSSDS ASLYHVFERS SLLSRSKKKG
KAGSPLTSIS KRRISCRDLG QGDCQGWLWK KKDAKTYFSQ KWKKYWFILK DTCLYWYMNE
EDEKAEGFVS LPEFKIDRAT ECRRKFAFKA CHPKIKTFYF AAENVDDMSR WLSRLSMAVA
GYSEQQEKMR QDQDYWSESD HEDMEMPSMS KQDSPPPPYD TYPRASSVSP YLEPKRGHLS
SSDTFQSRSS HEEFRPESQE GSSNNGISPG PKTSSHRNSW HDQMESNTRM HYLQTFPMEE
SLLSEDRDQL AMEYRRQATL PAQRSLLQEQ YRALPLPLRA SIDSEAGGKP RSFTLPRDSG
LHAILAATAA SDQGEPHAVH ECWQQGAVHE NRRQMGMQTD SLVDLYRALE QTNLSDHRPA
NRLEYKRSFV RRVNDPLLND KLHRLRILHS SLNSLTHPHT LMHTSSTVYF
//
