ID I3J9F1_ORENI Unreviewed; 1635 AA.
AC I3J9F1;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Alsin {ECO:0000313|Ensembl:ENSONIP00000005491.2};
GN Name=ALS2 {ECO:0000313|Ensembl:ENSONIP00000005491.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000005491.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Ensembl:ENSONIP00000005491.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSONIT00000005495.2; ENSONIP00000005491.2; ENSONIG00000004358.2.
DR GeneTree; ENSGT00940000155861; -.
DR Proteomes; UP000005207; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd13269; PH_alsin; 1.
DR Gene3D; 2.20.110.10; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 3.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR003409; MORN.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR037191; VPS9_dom_sf.
DR PANTHER; PTHR46089:SF3; ALSIN; 1.
DR PANTHER; PTHR46089; ALSIN HOMOLOG; 1.
DR Pfam; PF02493; MORN; 7.
DR Pfam; PF00415; RCC1; 4.
DR Pfam; PF02204; VPS9; 1.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00698; MORN; 7.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF82185; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 2.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00626; RCC1_2; 3.
DR PROSITE; PS50012; RCC1_3; 5.
DR PROSITE; PS51205; VPS9; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT REPEAT 62..109
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 110..173
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 174..224
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 493..544
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 545..595
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 956..989
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1476..1623
FT /note="VPS9"
FT /evidence="ECO:0000259|PROSITE:PS51205"
FT REGION 229..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 275..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 352..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 431..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..259
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1635 AA; 181223 MW; 2421ACFF0265E45E CRC64;
MENPEASLAD EQAHTSPDRG LLHVWHSAGH SRQLCPDRVL LSRPVLQVSL GEHHGLLLAQ
GGQVYSFGEL LWRDLSVPVS APVPEVSLLG KTMVHVAAGG FHCGALSEQG SVYMWGENTA
GQCGQTEKGT VTNITVPEPC PVSVVDGEVV PPVVVRVVDL ACGREHSLAL SAQNELWAWG
SGCQLGLVTS TFPVGKPQKV EHLAGRHVIQ VACGAYHSLA LVRRLPPQDY NTQHAPKKKE
RGQSPHYSVT EREELSAVED SHYCPLGVEL TEVMKGEASS QVRGPRRRLR AGATSASSSP
GSDDSKSNTK HPNLESQGQT DSVTETDGSP KVHLLSADEL ELQNLLEKLS DQSLDKQDTD
SLSSHTSDDS CISSTPSSDL LTSSYKDDLN TKRQMHNNSG LSGSHSSSPV CLNEVRLCLE
KEKRSLQGLK SSSLTNIYQK GKTATSRRSS LPGTPTHGSP RRRHPCACRP SSAGGASAGA
PEEAEDGLPF LETEIWSWGR GSEGQLGHGD QLARLQPLCV KSLTGEEVIK VAAGSHHSLA
LTAQCQVYSW GSNMCGQLGH VNIPVTVPQQ AKLSDGLRVW DLSAGQSHSL LLADGDCVQP
VLLYCGQQKE PVQTERLNQS ESSSKRSPSR VERYTVMPTL LPFCIEMGYV SSVCSGGQSC
AVLADHNVMG FISAIHELAS RERHLYCWCS SVRKILLTPL RKRDSLCPVL GEQCTHLFFS
LCESFVQLST LIGRHATALT YFLHNVQGCD VTTLPLLTHT EYFIDAYKRY FSSLGDFQVM
GGFQPLHKLS LESLGFRQTL LTQLSVSDQS ASGDVDLVSM LYWPLQQLHQ YSRALLKLAA
CYDVLTVEYK SLDQGHKDCE SLSSSLLRRK KEAETTFLFW KTHSGKTTEC LRLPRRRVVC
ESSNRSLTLQ NAGRFSNHWF ILFNDALVHT QFSTHHVYPL TCLWVKPVTE NGSGLHALKI
TCPEESFTLV ASTPQEKNKW LRSLNQTVDQ ILGGGGQGSS PAMTRTASYT FTADERFKDA
QYTGSWLAGR VHGRGTMKWP DGRLYKGNFK NGLEDGYGEC VIPNKLLNKT DTYQGQWREG
KIHGFGKYKY ASGEVYEGCF CDGQRHGYGM LSSGKLARNS SSVFIGQWVH DKRTGYGVYD
DITRGEKYMG MWLDDQRHGS AVIITQHGVY FEGAFRENKM SGLGLLMSDD DTVFHGEFTD
DWTISGKGIL TMPNGDSLDG QFSGEWSSGL KVVGTYTKPG IDEPPNKEKN GLNRLGQYAV
PADQRWICVF DECWSRLGCE AAGKGERTTA WENIAVTITT ARRQSPDLSR SQTKVLECLE
FIPQYEDPVT AANYDNIRRY LTKACETPHH PLGWLVETLV TAYRMTYVGV GSNRRLLRQA
VQEVLAYLTH FYSVIRFLFP GLPDDGSVLP DAPTSPSKSR RNSYTTGQGC VMVVSSSSLL
LPLLLPRLYP PLFTLYSLQE EQEETEYWER ILRLNKQPDQ SLLSFLEVQE KFWPLWMSIL
GEKKQIVSSS KDACFVSAVE TLQQISTRFT PSDKLMVIQK SFEELTLEVK PLLDGDFLWC
MDDLFPLFLY VVLRARIRNL GAEISLIEDL MDPNIQHGEL GLMFTTLKVS AADSQTHLHK
RCKSIRLCEM LMFLQ
//
