ID I3J9R3_ORENI Unreviewed; 1497 AA.
AC I3J9R3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Cytoplasmic linker associated protein 1a {ECO:0000313|Ensembl:ENSONIP00000005603.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000005603.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Ensembl:ENSONIP00000005603.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Golgi
CC apparatus, trans-Golgi network {ECO:0000256|ARBA:ARBA00004601}.
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DR Ensembl; ENSONIT00000005607.2; ENSONIP00000005603.2; ENSONIG00000004450.2.
DR GeneTree; ENSGT00940000154817; -.
DR HOGENOM; CLU_005060_0_0_1; -.
DR Proteomes; UP000005207; Unplaced.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0015631; F:tubulin binding; IEA:InterPro.
DR GO; GO:0031110; P:regulation of microtubule polymerization or depolymerization; IEA:UniProt.
DR GO; GO:1902903; P:regulation of supramolecular fiber organization; IEA:UniProt.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR048491; XMAP215_CLASP_TOG.
DR PANTHER; PTHR21567; CLASP; 1.
DR PANTHER; PTHR21567:SF28; CLIP-ASSOCIATING PROTEIN 1; 1.
DR Pfam; PF21040; CEP104-like_TOG; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR Pfam; PF21041; XMAP215_CLASP_TOG; 1.
DR SMART; SM01349; TOG; 4.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 4: Predicted;
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..232
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 168..206
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 310..545
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 806..1034
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 1260..1495
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 232..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 540..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 769..798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1070..1111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 540..569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 576..620
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..679
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 688..716
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 782..797
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1497 AA; 165149 MW; 3237474E1A72A7AF CRC64;
MEPSMENCLA LVLQKDMGRR LQVGQEIIDY ILDKEKSHDL EQDQTALDKM VDGIASSWVN
SSNFKVALLG LDLLSALVTR LQERFRAQVG TVLPSLIDRL GDAKDQVRET DQTLLLKIME
QAANPQYVWD RMLGGFKHKN NRTREGVCLC LIATLNTYGA QGLTLNKIVP HICNLLGDPT
SQVRDGAMSS LVEIYRHVGE RVRLDLSKKG LPQSRLNVIF SKFDEVQRSG NMISSSDKNF
EDEDSVDGGR SSSSSSKAPP SGRRTVVSSV RRPSSATTPK PTGKEAAAGA VDEEDFIKAF
EDVPSVQIYS NREFEDQLTK IREVLSDDKH DWEHRVVALK KVRSVMLAGA TDYEGFPQQL
RLLEASLKLS AKDLRSQVVR EACITLGHLS SILGNKFDHA AESVMPTLLN LVPNSAKVMA
TSGVAAIRLI LRHTHYPRLI PIITSNCTSK SVAVRRRCYE FLDLMLQEWH TNTLERHVAV
LTETIKKGIH DADSEARSIA RKCYWGFHGH YSREAEHLFQ ALEATYQKAL QSHLKSSDSI
VSLPQSDRSS SSSQESLNRP LSVKSVIGGS MTRSKLVGSR VPSTPGSLQR SRSDIDVNAA
SSAKSRLSTV PASSPFSSAA ALPPGSYASL GRVRTRRQSS GSVGGASSSS VVDSRGRSRA
KVVSQSQPGS RSSSPGKLLG HSSYGRIPRA TASASTTPAD KRSRIPRSQG CSRETSPSRL
GLDRYGLVHQ ARISASVNAM RVLNTGTEVE AAVADALLLG DSRNKRKTLR RRYESPGMYS
DDDANSDASS ACSERSYGSR NGGIPHYLRQ TEDVAEVLNH CASSNWSERK EGLLGLQNLL
KSQRILSRVE LKRLCEIFTR MFADPHSKVF SMFLETLVDF VTVHREDLQD WLFVLLTQLL
KKMGADLLGS VQAKVQKALD VTRESFPFDQ QFNILMRFIV DQTQTPNLKV KVAILKYIES
LARQMDPTDF VNSSETRLAV SRIITWTTEP KSSDVRKTLH NWVSEELAGR SSTAALLQST
EGNQEERCKQ AAQVVLIALF ELNTPEFTML LGALPKTFQD GATKLLHNHL KNTSNTSSNG
SPSNTIGRMP ARHTPSRTSP LTSPTNCSHG GLSPSMMEYD TENMNSDEIY SSLRGVTEAI
QSFSYRSQED LNEPIRREAK RDDAVRVASS PGSDARLGLD VVEGGRTALD NKTSLLNTPS
PRSFSGPRTR EFAPYGFGET ICTYDKSALK EAVFDDDVEQ FRDCRRQESG ENKMALPKVF
APVGQDHSDL VADLLKELSN HNERSEERKG ALVELLKITR EDSMAVWDEH FKTILLLLLE
TLGDKDHTIR ALALRVLKEI LRNQPARFKN YAELTIMKTL EAHKDSHKEV VRAAEEAAAT
LAGSIHPEQC IKVLCPIVQT ADYPINLAAI KMQTKVIERI AKESLLQLLP DIIPGLLQGY
DNTESSVRKA SVFCLVAIYS VIGEELKPHL AQLTGSKVLT VASKPVQSSS GTSTSCS
//
