ID   I3JAJ1_ORENI            Unreviewed;       584 AA.
AC   I3JAJ1;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 62.
DE   RecName: Full=SRCR domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000005881.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000005881.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR   AlphaFoldDB; I3JAJ1; -.
DR   STRING; 8128.ENSONIP00000005881; -.
DR   Ensembl; ENSONIT00000005885.2; ENSONIP00000005881.2; ENSONIG00000004671.2.
DR   eggNOG; ENOG502QU48; Eukaryota.
DR   GeneTree; ENSGT00940000164412; -.
DR   HOGENOM; CLU_032646_0_0_1; -.
DR   InParanoid; I3JAJ1; -.
DR   OMA; AKSELYM; -.
DR   TreeFam; TF331368; -.
DR   Proteomes; UP000005207; Linkage group LG23.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   CDD; cd18496; BACK_LGALS3BP; 1.
DR   Gene3D; 1.25.40.420; -; 1.
DR   Gene3D; 3.10.250.10; SRCR-like domain; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR001190; SRCR.
DR   InterPro; IPR017448; SRCR-like_dom.
DR   InterPro; IPR036772; SRCR-like_dom_sf.
DR   PANTHER; PTHR24410:SF16; GALECTIN-3-BINDING PROTEIN; 1.
DR   PANTHER; PTHR24410; HL07962P-RELATED; 1.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00530; SRCR; 1.
DR   PRINTS; PR00258; SPERACTRCPTR.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00202; SR; 1.
DR   SUPFAM; SSF54695; POZ domain; 1.
DR   SUPFAM; SSF56487; SRCR-like; 1.
DR   PROSITE; PS50097; BTB; 1.
DR   PROSITE; PS50287; SRCR_2; 1.
PE   4: Predicted;
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00196}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Secreted {ECO:0000256|ARBA:ARBA00022530}.
FT   DOMAIN          52..152
FT                   /note="SRCR"
FT                   /evidence="ECO:0000259|PROSITE:PS50287"
FT   DOMAIN          188..255
FT                   /note="BTB"
FT                   /evidence="ECO:0000259|PROSITE:PS50097"
FT   DISULFID        77..141
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT   DISULFID        90..151
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT   DISULFID        121..131
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
SQ   SEQUENCE   584 AA;  65693 MW;  F9C084F4FD5E1888 CRC64;
     MKREECIFNT DTCCTFAFLL QFSAIKMNGN AFIFCILLLS VTLSSAYEEG YIRLAGGQEY
     SEGRVEIFHD GVWGTICDDG WDINDAHVVC RQLRFPGAAE APGSAAFGAG VGNIWMDDLT
     CGGSEINLLQ CTFPGWGVHN CGHGEDAGVR CEKGAEPQSR DFNHEYTLDH NASLSQQLGE
     LFDSRQDCDV DIAVAVDNNI VETICAHRVI LSLNSNLKAL HPDLSSLLIN VSSDCSQHAN
     IFVRYFYTRK ITVTLASSHC ILKMASDWGL TEYHNEAANL FRLFLPEDPT FQSQNSLYEY
     AVRRSDDTLQ QLCLRYLAWN CEALINSPAW TSLPFNLVKA LLSRSDLVVR NETVVLSGLE
     RWAEARGNAT MREILLKLVR FPMIPAEDLY SLDSSEYHAS KLEGFQFNAL PVKMLLSDLT
     ETIYTPRIYT GRPWSFTFSS QEIRAYQHSG VYILRGQRVS SLTSDLQTPV HNSAYFAFHT
     MRWKTTAYVR EEDCTKQSVT CASLPAISLK IEEKNLPSEM EGRIRYSNRL VLMCAGRHVF
     HVNEFNAVDS DSPIAVPSIS EQVYPCHSNL FSYQVVVRPQ YSTD
//