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Database: UniProt
Entry: I3JAS5_ORENI
LinkDB: I3JAS5_ORENI
Original site: I3JAS5_ORENI 
ID   I3JAS5_ORENI            Unreviewed;       845 AA.
AC   I3JAS5;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   05-JUN-2019, entry version 61.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000005965};
GN   Name=VAV3 {ECO:0000313|Ensembl:ENSONIP00000005965};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000005965, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000005965}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [2] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C.P., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
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DR   EMBL; AERX01042049; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01042050; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSONIT00000005969; ENSONIP00000005965; ENSONIG00000004736.
DR   eggNOG; KOG2996; Eukaryota.
DR   eggNOG; ENOG410XPH6; LUCA.
DR   GeneTree; ENSGT00940000155252; -.
DR   InParanoid; I3JAS5; -.
DR   OMA; HEFKMHT; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR   CDD; cd00029; C1; 1.
DR   CDD; cd00014; CH; 1.
DR   CDD; cd01223; PH_Vav; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd11978; SH3_VAV3_2; 1.
DR   Gene3D; 1.10.418.10; -; 1.
DR   Gene3D; 1.20.900.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR022613; CAMSAP_CH.
DR   InterPro; IPR001715; CH-domain.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR037832; PH_Vav.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR035734; VAV3_SH3_2.
DR   Pfam; PF00130; C1_1; 1.
DR   Pfam; PF11971; CAMSAP_CH; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF07653; SH3_2; 2.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00109; C1; 1.
DR   SMART; SM00033; CH; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00326; SH3; 2.
DR   SUPFAM; SSF47576; SSF47576; 1.
DR   SUPFAM; SSF48065; SSF48065; 1.
DR   SUPFAM; SSF50044; SSF50044; 2.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50021; CH; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50002; SH3; 2.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005207};
KW   Guanine-nucleotide releasing factor {ECO:0000256|SAAS:SAAS01163629};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00253054};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW   SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192,
KW   ECO:0000256|SAAS:SAAS01042643}; Zinc {ECO:0000256|SAAS:SAAS00253075}.
FT   DOMAIN        1    120       Calponin-homology (CH).
FT                                {ECO:0000259|PROSITE:PS50021}.
FT   DOMAIN      192    371       DH. {ECO:0000259|PROSITE:PS50010}.
FT   DOMAIN      400    502       PH. {ECO:0000259|PROSITE:PS50003}.
FT   DOMAIN      513    563       Phorbol-ester/DAG-type.
FT                                {ECO:0000259|PROSITE:PS50081}.
FT   DOMAIN      593    659       SH3. {ECO:0000259|PROSITE:PS50002}.
FT   DOMAIN      671    765       SH2. {ECO:0000259|PROSITE:PS50001}.
FT   DOMAIN      787    845       SH3. {ECO:0000259|PROSITE:PS50002}.
FT   COILED      292    312       {ECO:0000256|SAM:Coils}.
FT   COILED      374    394       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   845 AA;  97777 MW;  C74517CA116FD5D7 CRC64;
     MEYWRQCALW LINCKVLPAN HRVTWDSAQV FDLAQTLRDG VLLCHLLNNL RPQTINLKEI
     NLRPQMSQFL CLKNIRTFLA ACSDVFGMKK SELFEAFDLF DVRDFGKVMD TLSKLSHTVI
     VQQTGIRPFP TEESVEDEDI YNHLEDLIDE NGVEDEEDLY DCVYDDEEGG EIYEDLMKTE
     AVPPPVCPPL DIRSCCLTEI KQTEEKYTET LESIEKHFMI PLNTFLSPAE MENVFVNIPD
     LVKVHKCLLL EIQDSVHHRS AQNLYQIFIT FKERLLIYGK YCSHVETAIA TLDDISKNRE
     DVRMKLEECS KRANYGKFTL RDLLVVPMQR VLKYHLLLQE LVKHTHDGTE KTNLRTALDA
     MKDLAQYVNE VKRDNETLRE IDQYQKSIEN LNQRLSNYGR PKVDGEVRVA SVDKRAKQDR
     HIFLFDAAVI VCKRRGDNYE MKEVIDLHLF KVTNNPTSDK ENRKWSYGFY LTHNQGQSGF
     EFFFKTKDLK KKWLEQFGMA ISNIRPENAT NNHHEFRMHT FERITSCNSC HELVKRGVFY
     QGYLCSKCGL GAHKECLGRF GSCGKTGKVF EGTCGSDKTN HHASYQLLLR SSKSLPKMLV
     IRNYFGSPSP ASGPALHIQT GDIIELICAD IHSPWWQGKI LSTKEVGFFP SDAVKPCPCV
     PKPVDYSSQP WFAGPMERLQ AEAELINRVN STYLVRHRSR EYTEYAISIK YNNDVKHIKI
     LTKEGSFYIA ENKKFRSIVE LIEYYKHHSL REGFRSLDTT LQFPYREMEN AAMHRFNRSG
     GNMFTPKVIG VAIARYDFSS RDTRELSLQE GDVVKIYTKS GANGWWRGEV NGRVGWFPST
     YVEEC
//
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