ID I3JAS6_ORENI Unreviewed; 4393 AA.
AC I3JAS6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=FAT atypical cadherin 3b {ECO:0000313|Ensembl:ENSONIP00000005966.2};
GN Name=FAT3 {ECO:0000313|Ensembl:ENSONIP00000005966.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000005966.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000005966.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 8128.ENSONIP00000030762; -.
DR Ensembl; ENSONIT00000005970.2; ENSONIP00000005966.2; ENSONIG00000004737.2.
DR eggNOG; KOG1219; Eukaryota.
DR GeneTree; ENSGT00940000154981; -.
DR HOGENOM; CLU_000042_2_0_1; -.
DR TreeFam; TF316403; -.
DR Proteomes; UP000005207; Linkage group LG10.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 31.
DR CDD; cd00053; EGF; 1.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 32.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF422; NEURAL-CADHERIN 2-RELATED; 1.
DR Pfam; PF00028; Cadherin; 25.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 33.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49313; Cadherin-like; 33.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00232; CADHERIN_1; 12.
DR PROSITE; PS50268; CADHERIN_2; 30.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..4393
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025343883"
FT TRANSMEM 4137..4157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..138
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 139..246
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 356..451
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 452..557
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 566..650
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 705..809
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 810..914
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 915..1020
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1021..1125
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1126..1232
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1233..1437
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1438..1543
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1544..1648
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1649..1746
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1747..1860
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1861..1974
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1970..2071
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2072..2173
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2174..2274
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2275..2381
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2382..2483
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2484..2587
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2588..2801
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2802..2915
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2916..3020
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3021..3122
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3123..3228
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3229..3333
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3353..3395
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3396..3500
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3797..4001
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 4004..4041
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4043..4079
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4081..4117
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 3931..3957
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4213..4252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 4031..4040
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4069..4078
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4107..4116
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4393 AA; 481658 MW; 69957E9EF5833876 CRC64;
KIFFLTSLFL LFYSRAGQRL LLFTQPAYNV SIFENSAART YTRSEAKMGI ILGPPWSFEI
KYSIVSGDSE DIFQAEDFVM GDFCFLRICT NGGSGAILNR EVQDNYTLTV KASAPGGLEA
LTTVYIRVLD TNDLRPLFSP TSYAFVVSES APLGASIGRV TATDADVGSN GEFYYFFKNK
IDLFAVHPTS GVITLTGRPR MDKQDRFELE VQVVDRGMKL YGNSGISSTA RLVLTVQRVN
EFAPVLSAVA VLPSWEEKNP VYAVINVEDK DEGVSGDIEW VSIIEGDPFE QFVVDRSPVG
NEYRVKTSEA VSWDTFPYGC NLTFQAKDRG MPPKFSNTQI VQLLVTKPDA VMASFEKDVY
VVTLSEIAPP GSVIEVVKIS PAPLRVNYSF SNPSDPMYFD INPLTGVIMT TRQLTRISQD
FMVMEVVDMI SEQRTSVQIQ IEDANDNSPV FNKPFYNIAV NESVPVGTVV LVVSAVDDDK
GENGYVSHTI SGEQSLPFSI DQKTGEVRIT RDLDFESSDD IYTFAVRASD WGSPYRRESE
VNITIRVINI NDNQPLFEKV SCRGMISRDF PVNQTVVTLS AIDMDELGLV EYKILSGNEL
DYFNLNPDSG ALSLKRSLAV DSLKSGVFNL KVVATDGEMF SDPTFVNISV VRGRIPPRGF
NCKDTRVAQL LAEKMLSKAS AMARPRPDES YTDIFSTNKQ PPQFEALPTS ILVREDLIPG
ASVFQVRARD GDTGFNGRVL FSISDGNKEN CFNINMESGL ITILRPLDRE RVDRYFLNIT
IYDQGIPQMS GWRLLTVIIE DTNDNDPQFY QDSYSALVSE NSAIGMEVIT ITAFDRDMGQ
NGQLSYIMLT SVPQFGIDSE TGSVFVASQL DRETFPIFIL KIEVRDMAER GTRRSSVTTL
SIILEDVNDC SPAFIPTSYS ARVLEDLPPG TVITWVQAQD PDIGPGGQVR YSLINDFNGT
FEIGPISGVL RIRKELDFEK QQFFNLTLLA EDRGIPSLRS QTFVELEVVD VSENLYAPYF
SDFAVRGSVK ENSRAGTSVL TVNAKDDDKG RDGVLKYSIQ GGSGLGTFTI DEDTGVIYTS
GILDCETKDS YWLTVCAVDR GVPPLSASVE VFIQVEDVND NAPLTSDPIY HPTIMENSPK
DVSVIRIQAQ DPDLTAIPSR LSYRITAGNP QNFFSINPKT GLITTTARKL DREQQAEHFL
EITVIDGPVT TRQSTVWVIV HVQDENDNPP TFPEVTYRIS LPERDRNKRG EPVYRVFAYD
RDYGANGNIT YSIISGNEDE KFSIDPRTAM VSSKKMVTAG SYDILTIKAE DSGDPPLWST
VKLHVEWIRK PAPSPVPLLF TQRYYNFSIS ETATVAQPVG VVAISQSSTP VWFTIIGSFD
MQFDLQLGVG TLVVAKPLDA EVQSVYNMTV QVTDGTNFAT AQVFIRIQDS NDNPPVFSLP
AYDISVSEDI PVDMELLRVR ASDIDERARL SFSIYGSVDP ASMRLFRVNP GTGVVYTADR
LDYEARTQHI LTIMVKDQEF PFNRDLARIL VAVEDSNDNI PYFTSTVYDA TAYETFSVGT
SVVQVTALDK DNGLNGQLTY TIEAGNTGGV FGIDNTTGLI FIAKELDLTS LGFYTLSVRV
TDSGFPPLMA TASVRISLIL SDFSKPKFSQ KEYQAEIMEN SKTGTYVITV SALSRSAIIY
DITRGNEERC FFINHHTGVI TTRKPLDFEQ TTSYFLVVRA LSMAGVEAST SVIIQVVDVN
DSPPVFQQIR YVGVVSEAAP INSVVLAEDG NPLVIQATDK DRNHNALLVF QIIGETARMF
FSVDSGTGSI RTIASLDYET FSEFVFRVHV RDSGQPPRDA DSPAEVLIKV ININDSPPKF
SQDTYETILL LPTYMGVEVL RVKALDPDVT SDPTLNPDKS ITPQLLYSLV DSNVEFFSVE
PYTGVVTVIN QNLNKDRYRF NVKVWDGRFS SMTLVTVLVR EAIDSGILFT FPVYSASIPE
NIPNITLVTV VSTVGHRLNE PLKYTLLNPV GRFSIRPTCG AVFTTGVPFD REEKDSYELV
VEVSREDEIL RVARVIVQVQ VEDVNDNSPQ FVNLPYYAVV QVEAQPGSSV FRVSATDKDY
SRNGQVTYGL KEQHRNFQVH PVTGELTLKR AFEADLSNAE YKLILVATDG GFPPLSSEVE
LPVSVVNKAM PVFDKPFYGV TVKEDVDVST SVLCINASSP EGQSVIFTIT DGDPSLQFDI
GFDTGIIRVI YPLDYETTQY YRLTVKATDT LTGAKSEVDV DIVMLDVNDN PPLFQNTSYS
AVLSENSMIG TPVLQVFAQD QDTEKNAVVS YQILSDIYNS TDYFSIDSNS GLIYTARLLD
YELIQRHNFI VRATDSGDPA LSSDVTVSVT VTDTNDNPPN FSQMLYEAFV SELAPKGHFV
TCVQASDADI CDASRLRYSI LSGNEKMTFM MEPDTGVLRL SNKRRQGMKL SYQLNVSVSD
GVFTSTAQVI VRVLGANLYS PVFSQRFYLA EVQENAPEGS KVIQVRATDE DSGLYGQITY
SFINDLGKTQ FTIDADGVIS TVQKLDRENP FNRDMVLTVM ALDGGGRASF CTVRVVLADE
NDNAPRFRAV EYRMSIKANV AKGSLVTQIQ ATDPDAGSNG RITYSLYSEA RLSLVDVLEV
EPDSGWMMTK STVDHLQGTV LSFFVKATDG GSPAKHSLVS AFIHVVPPDA FVPSFSQPQY
SFTIPEDTAV GTALGSVYMG AGQTGFFSAI AGETLDSNQE GTFLVEKETG LIRLVKPLDY
EEVSIFRFKV AATTRRDLIE SVSTVDLEVK ILDVNDNKPL FETSTYVATV MEGMPVGTRV
VQVRALDPDW GSNGQVTYNL TRDAGSFSGP VSTTSVFAID SKTGWITTVS QMDHEACSSY
SFEVVASDLA ELLPLSSTTV VTITVSDVND NPPLFERELY RGAIKESDPL GEVVAILKTK
DRDGTDQNRL VSFCITGGNP RGVFGLALVQ GEWKVYVSGL LDREQQDWYL LNITASDGLY
VAHTAVEVTV MDANDNRPIC NQAVYSTSFP EDVPINKGIL RVGATDADSG SSAEIQYSLF
GIGVEDFYMD ANTGELRTAI VMDRELAPSY KLIAQATDGG GLFCRSDIFL KVLDVNDNAP
LFSSTHYLAS VYENASPKAL LTRLQASDPD EGLNRTVLYS LVDSVNGFFS IDPVTGVVVL
EKSLDRESRD SYRVRVQATD RAGQQGALSS QVDLTILVLD VNDNAPVFQR RDYAVTVPED
VAVGTEVVRV LATSADIGPN AEITYNIRSG NELGKFTIDR KWGSISVADD LDFEVCKDYY
LTIEAWDNGN PPLSTATMVT IELMDVNDNA PAFSQDIYNL LVSHFLSLRV SKLDRELVSR
YSLSVQAFDS GSPAMSSTVT INIDISDVND NPPVFNPPNS TVVIQLNQAA GTTLLQLSVS
DKDSPKNGPP FEFWIKSGNE GNFFSLDQTG TLRCNRVFGP EAPREFTLEI QATDSGKPSL
SSSSWVFLRV IGNSQYKPTV SPLEIFIVMV TDTFPGGPIG RISATDRDLS DVLSFTQKPQ
PKSMFKVNRQ DGSIVALPGL EPGRYQMNAT VSDGRFAVIA DVSIQVEQVT DVMLRSALTL
RFNLLSPEDL LSRYLSQIKL TLRGLGGWKW SPGQQDPLHI LGVQPVMGTS DVDLLLAMER
PETPGSGRMG VFYSQQELSA KLEEGAAQGQ IRGVLAGAVV VSSACSGELE CGDRVCENTL
VMDGSSPVTY STERVSLVSS TFSRKETCTC PGGTCPTPVE LCEGQSCPAD MQCVRSGPTA
PSVCQCQPER LDDCAGQTSL SFSGNSYIKY RVTASGQSGE MKLGLRIRTL QRRGVIMFTR
VNPCTMLKIE GGRLWFQLDC DNTLGIMGIS GRPINDGLWH AVTLELTMNY TLLSLDDSYV
ERRRAARAPV RLWPLAPDSS FFFGAQVRPL NGQGEKPGPG SARSQGGPGL GERGVRGPPR
AQDGFQGCLG SLMLNGNELP LQNKRSRYAE IAGLSEVKLG CVLYPDPCVS QPCLNGAICS
SLPSGGFMCT CSVGFTGGRC EIELTSCMPN PCQNGGDCKP VGSAFLCGCP TGLGGLTCDG
DVNECDQEAC GNGGECVNTF GSFYCNCSEG YEGQLCDDLT PVLNILGPLS YVGPGEIIGI
GVLAFVIIFL LILFIVFRKK IKFRKDSDPG PGIQTGMGIS AISTETSYML HKTGMGAEGI
EFKAVRVSGS PATTSTYGEV GGSSVGPPQV MVRPTAHSPL PGGLSGDRTT SSEGSQVCIR
MANRRGVAVC SVAPNLPSAS ACRSEHSPAH KVSWEGEEMR EKELERARDE REEEWGQRAF
ELERTQRDNS PQGKTATVSL HTHTHTHTHT HTRAHTASNL IKKAKSTQAM NTLCYTNTTI
FTERAHFTVL YAF
//
