ID   I3JB28_ORENI            Unreviewed;       452 AA.
AC   I3JB28;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 55.
DE   SubName: Full=Inositol polyphosphate 5-phosphatase K {ECO:0000313|Ensembl:ENSONIP00000006068.2};
GN   Name=INPP5K {ECO:0000313|Ensembl:ENSONIP00000006068.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000006068.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000006068.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase
CC       type II family. {ECO:0000256|ARBA:ARBA00005910}.
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DR   AlphaFoldDB; I3JB28; -.
DR   STRING; 8128.ENSONIP00000026886; -.
DR   Ensembl; ENSONIT00000006072.2; ENSONIP00000006068.2; ENSONIG00000004821.2.
DR   eggNOG; KOG0565; Eukaryota.
DR   GeneTree; ENSGT00940000156538; -.
DR   TreeFam; TF317034; -.
DR   Proteomes; UP000005207; Linkage group LG10.
DR   GO; GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro.
DR   CDD; cd09094; INPP5c_INPP5J-like; 1.
DR   Gene3D; 2.60.40.2840; -; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR046985; IP5.
DR   InterPro; IPR000300; IPPc.
DR   InterPro; IPR041611; SKICH.
DR   PANTHER; PTHR11200; INOSITOL 5-PHOSPHATASE; 1.
DR   PANTHER; PTHR11200:SF117; INOSITOL POLYPHOSPHATE 5-PHOSPHATASE K; 1.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   Pfam; PF17751; SKICH; 1.
DR   SMART; SM00128; IPPc; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          15..337
FT                   /note="Inositol polyphosphate-related phosphatase"
FT                   /evidence="ECO:0000259|SMART:SM00128"
FT   REGION          280..301
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   452 AA;  52028 MW;  DFE9D0DCF29E6A50 CRC64;
     SQPQKSEEKS SQSLFLTRLH IVTWNVATAE PPEDATSLLQ LDAQPPTDLY VIGLQEVNAT
     PVRFITDLIS EDSWSHVFMD SLAPRGFVKV TSVRMQGLLL LLFAKQIHLP YIRNIQTTYT
     RTGVFGYWGN KGGVSVRFSF YGHMLCFLNC HLAAHMNNAL QRVDEFEYIL ETQDFDIYDT
     PQIRDHKVVF WFGDLNFRIA DHGLHFLRSS INSGRLNLLW GKDQLIMMKK KEAFLQEFEE
     GPLNFKPTYK FDRNSDTYDT SGKKRKPAWT DRILWRIKPK PLPSEDDDEK ASTSTDEEQD
     EYPVLVTQDK YTSDMSYGVS DHKPVIATFS LELRKVFDTP LVRVSPVGIW SADQDALLTY
     SVLEDFMSST WDWIGLYKVG FKTASDYETF VWVREKELPE INEVIQVKWK CSVYCQIPLL
     GGQYVLGYYS TNMQSITGLS DSFQVTASLS YL
//