ID I3JBI6_ORENI Unreviewed; 638 AA.
AC I3JBI6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=DIX domain containing 1 {ECO:0000313|Ensembl:ENSONIP00000006226.2};
GN Name=DIXDC1 {ECO:0000313|Ensembl:ENSONIP00000006226.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000006226.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000006226.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005472231.1; XM_005472174.3.
DR AlphaFoldDB; I3JBI6; -.
DR STRING; 8128.ENSONIP00000006226; -.
DR Ensembl; ENSONIT00000006230.2; ENSONIP00000006226.2; ENSONIG00000004949.2.
DR GeneID; 100709877; -.
DR CTD; 85458; -.
DR eggNOG; ENOG502RD5G; Eukaryota.
DR GeneTree; ENSGT00950000182903; -.
DR HOGENOM; CLU_025678_0_0_1; -.
DR InParanoid; I3JBI6; -.
DR OMA; MPHISAR; -.
DR OrthoDB; 3042644at2759; -.
DR TreeFam; TF318198; -.
DR Proteomes; UP000005207; Linkage group LG10.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd21213; CH_DIXDC1; 1.
DR Gene3D; 2.40.240.130; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR001158; DIX.
DR InterPro; IPR038207; DIX_dom_sf.
DR InterPro; IPR015506; Dsh/Dvl-rel.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR10878:SF39; DIXIN ISOFORM X1; 1.
DR PANTHER; PTHR10878; SEGMENT POLARITY PROTEIN DISHEVELLED; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00778; DIX; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00021; DAX; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50841; DIX; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687, ECO:0000256|PROSITE-
KW ProRule:PRU00069}.
FT DOMAIN 21..128
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 550..632
FT /note="DIX"
FT /evidence="ECO:0000259|PROSITE:PS50841"
FT REGION 206..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 447..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 519..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 311..345
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 374..443
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 209..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..551
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 638 AA; 71196 MW; FAF17C261797BB6C CRC64;
MIASLSRGSL MDEVLHGGFN EQQLAAYVSW VNSQLKRKPG LKLIADLRHD LQDGVVLTQL
IEIVAGEVLE GVYAAPQNKE ESRKNVEEVL RFISSRHIRM PHISARDIVD GNLKSVMRVI
LALAAHFKPT ANHRNASGSG RRLTRSHASH NPLSTVALAQ GAAATLASAR HDASLPTHTA
RLHSGCGLDG EKSVCVRALV EQYERGAPDE QDNLQQSSSV SPLSSPRAPA SSHSDRQEQD
QEQQQSSAES SQVAVEMTWG DTLNDTLEKE VQETRKMVSA LQALLLRGSL PEDEQDASLT
LEQGNTSEQQ LVVIRSRLDQ SMEEAQELKR ELLCCKQEVR NLQGVKDAQQ QRLCTQEALI
LQMKQELLRA SMTKDELNSK NAELQWKLEE CNRLWAECKK EVAQKDRLLQ QLKHKLEESQ
NMQNELQREL EHKNSTLQEL MSRDPQQIPT SAENNGCSYP GNPAPSVSGQ AEEVQLLRDA
LRSLRNNFRD HDPQHHTLDT LEQGIVSLID RLHVLHTQRG RGKSPRCKGQ HGDLDSLSST
KNCQSHGGSS SSTKILYFTG KSPTPSMINI PKRLGEVTLK DVKAAVDREG NYRYHFKALD
PEFGTVKEEV FLDEAIVPGW EGKIVAWVEE DCGEERPL
//
