ID I3JBP7_ORENI Unreviewed; 1665 AA.
AC I3JBP7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Dedicator of cytokinesis 2 {ECO:0000313|Ensembl:ENSONIP00000006287.2};
GN Name=DOCK2 {ECO:0000313|Ensembl:ENSONIP00000006287.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000006287.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000006287.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR STRING; 8128.ENSONIP00000064953; -.
DR Ensembl; ENSONIT00000006291.2; ENSONIP00000006287.2; ENSONIG00000004998.2.
DR eggNOG; KOG1998; Eukaryota.
DR GeneTree; ENSGT00940000154903; -.
DR HOGENOM; CLU_000595_2_1_1; -.
DR TreeFam; TF300423; -.
DR Proteomes; UP000005207; Linkage group LG2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF6; DEDICATOR OF CYTOKINESIS PROTEIN 2; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 380..570
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1147..1554
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 530..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1583..1603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..557
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1665 AA; 192958 MW; 5C0CB74D1C18379D CRC64;
MPLCLSGWYR GYLSRNKAQQ GVFPVSFVQV KEVIIEKRGD EEVVMSAEMP LVKEVTTTLR
EWGSIWKQLF VANKEARVKQ VQRLMWELME WRSQLLSGTL PSDEFKELKQ KVTSKIDYGN
KILELDQVVR DDDGNILEPE RASVISLFRA HEEATAKIGE RIKEEQSNIQ TDHSGISARI
QSSPTHSLYV FVRNFVCRIG EDSELFMSLY DPNKQTIISE NYLVRWGSKG FPKEIDILHC
IFFHLSREKI YLICQIVRVG RMDLKEANNK KFTQGLRRPF GVAVMDISDI IKGKIECDEE
KQYFIPFFPV VAENDFLHTL LNKVTTSRGD SGGQGLWVTM KALVGDIVQI RKEYPHLVDR
STVVARKLGF PEIIMPGDVR NDIYLTLQGG DFDKYNKTTQ KNVEVIMWVC DEEGKVIQNS
ICLGAGDKAV SEYRSVIYYQ VKQPRWMETF KVAVPLEEMH RIHLRFMFRH RSSQESKDKS
EKNFAMAFVR LMKEDGTVLQ DGLHELVVFK GDSKRMEDVN CYLNLASTRN HHSDPHKMST
LSRSSSSVSG GGGGLSVSSR DSFTISTLVC STKLTQNVGL LGLLKWRTRP ELLKENLEKL
KIIDGEEVVK FLQDTLDALF NIMMEHSQTD DYDILVFDAL IYIIGLIADR KFQHFNTVLE
AYIKQHFSAT LAYKKLMSVL KRYLDVSSRG EQCEPILRTL KALEYIFKFI VRSRMLYSQL
YEGKEQAEFE ESLRRLFESI NNLMRTDYTT TLLLRVITYT HPASTLHNLV HLITFQLLHD
FYSCIPPEKL QKQKVASMTE IVSSQLFQRQ ECRDVLLPLM LRELSGALIT MADGPHDERK
NSLELLNNIL EVLSRNNVGD TFQHIQDIVV SLLRVINQTV ITMGREHTLI VSTLQIGHMV
DSSEPSDFLM ESFLLFKDLI GKHVYPSDWM AMIMVQNRVF LRAINTYADT MKEKFLNNDD
FEVQLWNNYF HLAVAFITQE SLQLQHFSPT KRNKILAKYG DMRRLIGFAI RDIWYKLGSH
KICFIPGMVG PILEMTLIPE EELRRATIPI FFDMITCEHA RFGNFSKFEN EIILKLDHEV
EGGGGDERYM QLLETILLDC AAEKHTLRPQ VQHFVSLVKG LLIRLLDYRT VMSDDSRNNR
MSCTVNLLVS PTFSEISWYL YKLRDLHLEC ENYTEAAYTL LLHSRLLKWS DDMCSQFEFH
GSQTQRQLKE TLYDTIIDYF DKGKMWEEAI TLCKELAEQY ENEIFDYELL SKRLEKQAKF
YENIMKILRP KPDYFAVGYY GQGYPPFLRN KVFIHRGKEY ERREDFQNQL MSQFPSAVRL
NTTTMPGDDI KNSPLQYIQC FTVQPVLEIP PRLKNKPVPD QIINFYKSNY VQRFHYSRPV
RKGPVDPNNE FASMWIERTT FTTVYKLPGI LRWFEATDMK HTTLSPLENA IETMESTNEK
ILTMINQYQS DWSLPINPLS MLLNGIVDPA VMGGFAKYEK AFFTEEYTQQ HQEDRDKLLR
LKDLIAWQIP LLGGGISLHG KRVTDDLRPF HERMEECFKQ LKKKVEKEYG ARELPDMDER
KSTRPRSMLR SFRQSVISIS SLQGSECGTD IPPESPVSWS SATLPRSSGS VSIGEEGSVM
TVGDAEVKMR KSKKKKKRSS MIFITEERER TSTLECKRVR ISDDG
//
