ID I3JCE4_ORENI Unreviewed; 712 AA.
AC I3JCE4;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Kelch-like protein 4 {ECO:0000313|Ensembl:ENSONIP00000006534.2};
GN Name=LOC100697681 {ECO:0000313|Ensembl:ENSONIP00000006534.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000006534.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000006534.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; I3JCE4; -.
DR STRING; 8128.ENSONIP00000006535; -.
DR Ensembl; ENSONIT00000006539.2; ENSONIP00000006534.2; ENSONIG00000005202.2.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00940000159818; -.
DR HOGENOM; CLU_004253_12_0_1; -.
DR TreeFam; TF329218; -.
DR Proteomes; UP000005207; Linkage group LG2.
DR CDD; cd18336; BTB_POZ_KLHL4; 1.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412; KELCH PROTEIN; 1.
DR PANTHER; PTHR24412:SF74; KELCH-LIKE PROTEIN 4; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 6.
DR PRINTS; PR00501; KELCHREPEAT.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 4: Predicted;
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 176..243
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT REGION 27..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..70
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 712 AA; 79221 MW; 12C0DEFB65E5F2D1 CRC64;
MSVSGKKEFD VKQILRLRWR WFSHSSQGSA GGGGGGVGGG GGYIQQDGLD HRGTPVQGRL
KSHSRERGVG GLRKTNSPVH SILAPTPGPT PVYVRAGHQS WHHQQSTIQG SQATIIFREK
TMFVQSCYLS LNVWIKLLYT FSRMNTNSSD EFFQATNHAE QTFRKMETYL QHKQLCDVLL
IAGDHKIPAH RLVLSAVSDY FAAMFTSDVR EAKQEEIKME GVDPEALRSL VHFAYTGVLE
LKEETIESLL AAACLLQLSQ VIQVCCNFLM KQLHPSNCLG IRSFADAQGC VDLLNVAHNY
TMEHFLEVIQ NQEFLLLPTA EIVKLLSSDD INVPDEETIF QALMMWVRYD VQNRQQDLGV
LLAYIRLPLL PPQLLADLEN NKMFSDDLEC QKLLMEAMKY HLLPERRPMF QSPRTKPRKS
TVGALYAVGG MDATKGSTTI EKYDLRTNTW VQVGVMNGRR LQFGVAVIDN KLYVVGGRDG
LKTSNMVECY NPVTKVWSTM PPMSTHRHGL GIAVLEGPMY AVGGHDGWSY LNTVERWDPQ
ARQWNYVASM STPRSTMGVT ALNGKLFAVG GRDGSSCLRS MECFDPHTNK WSMCAPMTKR
RGGVGVATYN NFLYAVGGHD APASNHCSRL SDCVERYDPK TDTWTTVAPL SVPRDAVGVC
LLGDRLYAVG GYDGQSYLNT VESYDAQNNE WTEEVPLNIG RAGACVVVVK LP
//
