ID I3JDP0_ORENI Unreviewed; 232 AA.
AC I3JDP0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Programmed cell death protein 10 {ECO:0000313|Ensembl:ENSONIP00000006980.2};
GN Name=LOC100697497 {ECO:0000313|Ensembl:ENSONIP00000006980.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000006980.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000006980.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cytoplasm
CC {ECO:0000256|ARBA:ARBA00004496}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004255}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004255}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004255}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the PDCD10 family.
CC {ECO:0000256|ARBA:ARBA00009181}.
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DR RefSeq; XP_005474576.1; XM_005474519.3.
DR AlphaFoldDB; I3JDP0; -.
DR STRING; 8128.ENSONIP00000006980; -.
DR Ensembl; ENSONIT00000006985.2; ENSONIP00000006980.2; ENSONIG00000005553.2.
DR GeneID; 100697497; -.
DR KEGG; onl:100697497; -.
DR eggNOG; KOG4025; Eukaryota.
DR GeneTree; ENSGT00390000017913; -.
DR HOGENOM; CLU_083906_1_0_1; -.
DR InParanoid; I3JDP0; -.
DR OMA; EFVHYSK; -.
DR OrthoDB; 3801237at2759; -.
DR TreeFam; TF105802; -.
DR Proteomes; UP000005207; Linkage group LG14.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0043009; P:chordate embryonic development; IEA:Ensembl.
DR GO; GO:0003007; P:heart morphogenesis; IEA:Ensembl.
DR Gene3D; 1.10.12.70; -; 1.
DR Gene3D; 1.20.120.330; Nucleotidyltransferases domain 2; 1.
DR InterPro; IPR046409; PDC10_dimerisation_sf.
DR InterPro; IPR009652; PDCD10.
DR InterPro; IPR048288; PDCD10_N.
DR PANTHER; PTHR13250:SF1; PROGRAMMED CELL DEATH PROTEIN 10; 1.
DR PANTHER; PTHR13250; TF-1 CELL APOPTOSIS RELATED PROTEIN-15; 1.
DR Pfam; PF06840; PDC10_C; 1.
DR Pfam; PF20929; PDCD10_N; 1.
PE 3: Inferred from homology;
KW Angiogenesis {ECO:0000256|ARBA:ARBA00022657};
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 13..70
FT /note="Programmed cell death protein 10 dimerisation"
FT /evidence="ECO:0000259|Pfam:PF20929"
SQ SEQUENCE 232 AA; 26556 MW; EDA1F9F05E935427 CRC64;
MTMGDMKNDA AAASLAPMAL YTVMFPVFKE LEKINLSAAQ TLRTAFIKAE KETPGLTQDV
VVKMLEKKKL KINYNEALLR MAGDDMQELM IDRKEPEFQE LNERARALKH ILSTLPDEIN
DRMGLLRTIK DVASAIKELL NTVNTVLRKY QHQNRRVVEQ QKKEFVKYSK SFSDTLKTYF
KDGKAVNVFV SANQLTHQTN MIMRAFKTGG PAAVAREDAN NRRAQTKEKR FH
//
