ID   I3JDP8_ORENI            Unreviewed;       486 AA.
AC   I3JDP8;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 55.
DE   RecName: Full=DEP domain-containing protein 7 {ECO:0000256|ARBA:ARBA00040225};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000006988.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000006988.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DEPDC7 family.
CC       {ECO:0000256|ARBA:ARBA00037970}.
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DR   AlphaFoldDB; I3JDP8; -.
DR   Ensembl; ENSONIT00000006993.2; ENSONIP00000006988.2; ENSONIG00000005559.2.
DR   GeneTree; ENSGT00950000182976; -.
DR   InParanoid; I3JDP8; -.
DR   OMA; YCTRVSA; -.
DR   Proteomes; UP000005207; Linkage group LG1.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd04405; RhoGAP_BRCC3-like; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR16206; DEP DOMAIN-CONTAINING; 1.
DR   PANTHER; PTHR16206:SF9; DEP DOMAIN-CONTAINING PROTEIN 7; 1.
DR   Pfam; PF00610; DEP; 1.
DR   SMART; SM00049; DEP; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          25..92
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|SMART:SM00049"
FT   REGION          94..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        94..125
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        127..142
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   486 AA;  55445 MW;  772EC1A5C6C99DC7 CRC64;
     VHTNLCMAGK PFRATYIWTS IISNLHTRVE VKRRRHNLKS YHDCFLGSEA VDVVLAHITL
     NPVKLCQALM DSRVFEPVGI KDSSFSLYRF LSPETNSSST LTGTNSLSTN TIESGYDSPS
     MERNTKGYSP LRERKEAQTT DKSLEDVLGN LNLSSTITPQ MINLGLSQEL VDEVWHQQAV
     FRLLQLIELP LLESLLEGKE TSRRALHGMD SDPDLLYTSS YLDREVLKAF SEAQADEWMS
     GAVDCLEFLP DELVVEISRG LAACGDDLIR CKRLLYQVLT KHYGHTQQPP LLSNHIFDIH
     SGISELLVNG KREQAVEALQ LSLKLQDSRS REELRRLLRF MSVAAKPEEV KLHKEIENRM
     AVKRSFSRAI IYSRRLSKGK VDLMVLFMMD NHCDLFKIPV SLHKMVSDRI TNIVKGKDPD
     ITEVYSQNTR KTTKEELVSL LRTVHESPTL SDKEKRRMLG QFYKGHPEIF VQYFGNKLST
     INMLLQ
//