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Database: UniProt
Entry: I3JE80_ORENI
LinkDB: I3JE80_ORENI
Original site: I3JE80_ORENI 
ID   I3JE80_ORENI            Unreviewed;      4922 AA.
AC   I3JE80;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   23-MAY-2018, entry version 41.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSONIP00000007171};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000007171, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000007171}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [2] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
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DR   EMBL; AERX01015182; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8128.ENSONIP00000007171; -.
DR   Ensembl; ENSONIT00000007176; ENSONIP00000007171; ENSONIG00000005692.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   OMA; REQWEKP; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 2.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005207};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4456   4476       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4531   4550       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4685   4702       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4722   4744       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4799   4822       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      110    165       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      172    217       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      225    279       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      285    333       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      350    407       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      582    807       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1023   1218       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1315   1519       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     2880   2900       {ECO:0000256|SAM:Coils}.
FT   COILED     3451   3471       {ECO:0000256|SAM:Coils}.
FT   COILED     3658   3678       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4922 AA;  557805 MW;  99F4B1B9A7117825 CRC64;
     WSISMLGQQD IQFLFWDDEV VLQSVATIQK EHRKFCLAAE GLGNRLCYLE STSEAKYVPP
     DICICNFVLE QSLSVRALQE MLANTGQNSE GSADHEKWRL IKKAGQGGGH RTLLYGHAIL
     LRHSFSGMYL TCLKTSRSLT DKLSFDVGLQ EDSIGESCWW TIHPASKQRS EGEKVRIGDD
     LILVSVSTER YLHLSISNGN IHVDASFMQT LWNVQPTCSS SNMAVGYLIG GHVMRLCHGH
     DESLTIPGAD KNEEEQRIVN YEAGKGASKA RSLWRVEPLR ISWSGSHIRW GQPFRLRHLS
     TGHYLALTED RGLVLQDRVK SDTTATAFCF RASKEKGDTG PKRDIDGMGV PEIKYGDSVC
     FIMHVATGLW LSYQAPDAKS SRLGPLKRRA CLHSEGHMDD GLILQRCQHE ESRAARIIRN
     TTFLFTNFIK ALDSIAAGES TAVAGYVEEV LQTLNDLIEY FKQPDSELEH EEKQCLLRSL
     IKRQDLFKEE GMLSLLSKCI DRMNLYDSAA HFGEVAGEEA GAAWKDILNL LYELLAALIR
     GNRNNCTQFS RKLDWLVSKL ERLESSSGIL EVLHCILVES PEALNIIQKG HIKSIVSLLY
     KHGRNHKILD VLCSLCVCNG VAVRANQNLI CDNLLPNRDL LLQTRLVNDV QSMRPNIFLG
     IAEGSAQYKK WYYELVIDQV DHFVTSEPTH LRVGWANTKG YAPYPGGGEG WGGNGVGDDL
     YSYSFDGLHL WSGRIPRAVA SINQHLLNSD DVVSCCLDLG APSMSFRING QPVQGMFEDF
     NTDGFFFPVV SFSAGVKVRF LLGGRHGDFK FLPPAGYSPC YEALLPKEKM HVEPVKEYKR
     DHDGVRDLLG TTQFLSQASF IPTPVDTSQI VLPPHLENIR DKLAENIHEL WGMNKIELGW
     TYGKVRDDNK RQHPCLVDFA KLPETERNYN LQMSSETLKT LLALGCHVAQ VNIHAEDDLK
     KIKLPKNYMM SNGYKPAPLD LSDVRLNAGQ EVLVDKLAEN AHNVWAKDRI KQGWTYGIQQ
     DLKSRRNPRL VPYALLDERT KKSNRDSLRE AIRTMVGYGY EIDPPDQEVV HVLDDQSVET
     IRFFRVEQTY AVKTGKWYFE FEALSGGDMR VGWARPGCRP DVELGVDDQA FVFDGYRGRR
     MHAGSRYFGH PWKKGDVVGC MINMEDKSMI FTLNGELLIT NKGSELCFTD FETEDGFIPV
     CSLSMSQIGR MNLGKDASTF KYYTMCGLQE GFEPFAVNMN REVTMWFSKR LPTFFNVPEE
     HPDIEVTRID GTVDSPPCLK VTHKTYGTQN SNNDMVYCRL SMPVEFYSAD KLLDESLKLR
     SDMEIVFYLN LYLKLKTKAH SVSVMFFVSA AILQKKMEVL TLEASQLITD STVFPFSFNW
     QYYYSVRVFA GQDPASVWVG WVTPDYHYYS KNFSLSKTRT VTVTLGDERG RVHESVQRSN
     CYMVCVADAV TPSSSSRSSS DLEIGCLADL ATGLVSFTAN GKELPTSYQV EPNTKLFPAV
     FVLPTSANLF QFEFVKIKDA MPLSSAIFKS EHRNPVPQCP PRLDVQTIVA VLWSRMPNIF
     LNVETARVSE RHGWVVQCLE PMQMMAVHIP EENRCLDIME LSEHEDLRKF HYHTLKLYCA
     LCALGNTRVA HALCSHLDQS QLLYTIDNQY LSGMLREGFY NVLISIHLET AKEARLMMNN
     EFIIPVTDET RSIKLFPDES KQHSLPGVDL STSLKPRVNF SPVGIINTKR QQYLYSPQIP
     LGILKEKAIS MLTEAVQGGG THIRDPVGGS LEYQFVPILK LIGTLLIMGV LTSDEVRLIL
     LLIDPNVFGE TKEGEEVKGD EVAMSGEKEE VSKNEEKAVE AGEEETKESK PQVKGLLEKS
     LPESVKRQMC ELLHYFCDCE LKHRIESIVS FSDSFVSKLQ YNQKFRYNEL MLALNMSAAV
     TAKKTKEFRS PPQEQINILL NFSAGEDCPC PEEIQDELNS FHEELRLHCG IPVEEEEEEQ
     DTSIKGRLLA LLYKIKGPPQ KTEQEPTETE QAAPTNLKEL ISQTITSWAQ ESHIQDPELV
     RVMFSLLRRQ YDGIGELLRA MKKSYTISAA SVQDAINLLA SLGQIRSLLS VRMGKEEEKL
     MIDGLGDIMN NKVFYQHPNL MRVLGMHETV MEVMVNVLGG DKSQEIAFPK MVASCCRFLC
     YFCRISRQNQ KAMFDHLSYL LENSSVGLAS EAMRGSTPLD VAASSVMDNN GLALALEEPD
     LEKVVTYLAG CGLQSCAMLV AKGYPDLGWN PIEGERYLSF LRFAVFCNGE SVEENANVVV
     KLLIRRPECF GPALRGEGGQ GLLAAMEEAI KISEDPALDL PKTPAGVTTG SGEEEGEVIH
     MGNAIMSFYS ALIDLLGRCA PEMHLINAGK GEALRIRAIL RSLVPTSDLV GVISIPLKMP
     VVNKDGTVTE PDMSACFCPD HKAPMVLFLD RVYGIEDQSF LLQMLEVGFL PDLRASASLD
     TEALSTTETA LAMNRYIGSA LLPLLTRCAA LFGSTEHHAQ LVDSTLQTIY RLSKGRSLTK
     AQRDAIEECL LAICKHLRPS MMQQLLRRLV FDVPVLNEYC KIPLRLLTNH YEQNWKYYCL
     PSGMGSFGTA SEEELLLTKK LFWGIFDSLS HKKYDAELFK MAKSCLCAIA GALPPDFVDS
     SLGATLEKQA SMDAQGNFDP KPISTANISL PEKLEYIANK YAEHSHDKWS SEKMSVGWKH
     GDTVDEQAKT HPLLKPYKSL SEKERETYRW PVRESLKSML SMGWNIERTK EGEAMFQQRE
     SEKQRKISES QINGFSPAPM DLHNVTLSRE LQGMVEVVAE NYHNIWAKKK KTELVSKGGG
     THPLLVPYDT LTAKEKYRDR EKAQELFKFL QISGYAITRG LKDMEQDSSS MEKRFSYKFL
     KRLLKNVDSA QEFIAHLEAM ATSGKTDKSP HDQEIKFFAK VLLPLTDQTF KNHCLYFLST
     PSQNLSSCGC ASNKEKEMVT SLFCKLAALV RHRISLFGSD SAMMVSCLHI LTHSLDTRTV
     MKTGSELVKV GLKTFFENAA EDLDKLLEML KLGKFMQSRA QMKSVSQSIN YVTVALLPIL
     TALFEHIKTY EFGVDLLLDD VQLSCYRILT CLYSLGTGKN VFVERHLPAL GESLATLVGA
     MPVAFLEPHL NAHNPLSVFN TKTPRERAIL SMPDTVEEMC PEMPRLDKLL KDVNDVSESG
     ARYSDMPQVI EVILPMLCNY LSYWWEKGPE NSPPDTQCCT MVTSEHLSII LGNILKILNS
     NLGIDDAPWM KRIAVYSQPI ICKAGADLLR THFLPTLDKL KKKTVKVVAE EELLKADSKG
     DNQEAELLIL DEFAVLCRDL YAFYPMLIRY VDNNRSRWLK EPDGDSTELF RMVAEIFILW
     CKSHNFKREE QNFVVQNEIN NLGFLTGEGK TKMSKTGGDQ ERKHKRRRGE YYSIQTSLIV
     AALKKMLPIG LNMCTPGDQE LISLAKIRYS LKDTDDEVKE HLRQNLHLQD KSDDPAVQWQ
     MNLYKDVVVK IEEPANPENT VDRVQSISAA VFHLEQNKLN WGCRIIPVFK VEQPLRNKKC
     VWQKLLSKQR KRAVVACFRM APLYNLPRHR AINFFIPAYE RLWIEAEEYS FEEKLVQDLA
     KTPMKIVEEE EEEVAEIQPD PLHQLILHFS HNALTERSHL EEDPLYIAYA DMMAKSCAED
     EEEEEEEEGK EKTFEEKEME KQKILYQQAR LHARGAAEMV LQMISASKGR LGPMVTCTLK
     LGISILNGGN VQVQQKMLDY LKEKRDAGFF KSLSGLMQSC SVLDLNAFER QNKAEGLGMV
     TEEGSSSKVL QNDEFTKDLF RFLQLLCEGH NGDFQNFLRT QTGNTTTVNI IISTVDYLLR
     LQESISDFYW YYSGKEIIDE TGKLNFSKAL SVAKQIFNSL TEYIQGPCIG NQQSLAHSRL
     WDAVVGFLHV FANMQMKLSQ DASQIELLKE LMDLQKDMVV MLLSLLEGNV VNGTIGKQMV
     DTLVESSSNV EMILKFFDMF LKLKDLTTSD NFKEYDPECK GIISKKEFHK SMESQKQYIQ
     SEIEFLLSCV EADENDMFNY KEFVERFHEP AKDIGFNVAV LLTNLSEHMP HDSRLATFLD
     LAESVLSYFE PYLGRIEIMG SAKRIERVYF EISESSREQW EKPQVKESKR QFIFDVVNEG
     GESEKMEMFV NFCEDTIFEM QLASQISEPE VVEQPEEDEE EDGHSILEEL TAEEEHALES
     ASAFTTACRS VSGKIAHVRQ MFSIKNMRKK FKKLKKLSIK EIITGFFAFF WMLFTGFFKG
     IYSLIFGFFH VIWSSMFGGG LVEGAKNIKV TDILGNMPDP TQFGIHGDVI EGEKVEAIES
     LGNLDIAMAP TGDIVEVDMM MEMLNAPKKE GGKHVEPGLG DVSELSAEPS TDHKKQKAAA
     KKVETPENEP EKADTENQEK EDKPKEEAAK EPVTEEKPKT RSSQPKEPAP AFMSSIFAVL
     DVYLNKTVNY LARNFYNLRF LALFVCFAIN FILLFYKVTQ ASVQVTGETD EETEGENRWG
     ADEEDDEDTL FDMDEFVLQE STGYMLPTLR FLAIFHTVIS LVCLVGYYCL KVPLVVFKRE
     KEIARKLEFD GLYITEQPSD DDIKGQWDRL VINTPSFPNN YWDKFIKRKV INKYGDLYGA
     ERIAELLGLD KSALDFDPTV ETVEKEASLV SWLSSIDTKY HIWKLGVVLT DNSFLYLIWY
     TTMSIFGHFN NFFFAAHLLD IAMGFKTLRT ILSSVTHNGK QLVLTVGLLA VVVYLYTVVA
     FNFFRKFYNK SEDEDEPDMK CDDMMTCYMF HMYVGVRAGG GIGDELEDPA GDPYELYRIL
     FDITFFFFVI VILLAIIQGL IIDAFGELRD QQEQVKEDME TKCFICGIGN DYFDRTPHGF
     ETHTLQEHNL ANYLFFLMYL INKDETEHTG QESYVWKMYQ ERCWDFFPTG DCFRKQYEDQ
     LG
//
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