ID I3JEC7_ORENI Unreviewed; 517 AA.
AC I3JEC7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Bardet-Biedl syndrome 4 {ECO:0000313|Ensembl:ENSONIP00000007218.2};
GN Name=bbs4 {ECO:0000313|Ensembl:ENSONIP00000007218.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000007218.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000007218.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309}.
CC -!- SIMILARITY: Belongs to the BBS4 family.
CC {ECO:0000256|ARBA:ARBA00023778}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_005455736.1; XM_005455679.3.
DR AlphaFoldDB; I3JEC7; -.
DR STRING; 8128.ENSONIP00000052952; -.
DR Ensembl; ENSONIT00000007223.2; ENSONIP00000007218.2; ENSONIG00000005728.2.
DR GeneID; 100692460; -.
DR CTD; 585; -.
DR eggNOG; KOG1124; Eukaryota.
DR GeneTree; ENSGT00940000158166; -.
DR HOGENOM; CLU_033477_1_0_1; -.
DR OrthoDB; 5481067at2759; -.
DR TreeFam; TF324966; -.
DR Proteomes; UP000005207; Linkage group LG1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44186; -; 1.
DR PANTHER; PTHR44186:SF1; BARDET-BIEDL SYNDROME 4 PROTEIN; 1.
DR Pfam; PF13414; TPR_11; 1.
DR Pfam; PF13181; TPR_8; 3.
DR SMART; SM00028; TPR; 8.
DR SUPFAM; SSF81901; HCP-like; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 6.
DR PROSITE; PS50293; TPR_REGION; 2.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 82..115
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 149..182
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 183..216
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 251..284
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 285..318
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 319..352
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 421..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 463..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..445
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..500
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..517
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 517 AA; 57815 MW; 10F8F7B3E486701A CRC64;
MLFLHPAPEL PIVERRNWLI HQHYILKDYD TCKVIIKDQL QETNGMCEYA IYVQALILRL
EGEIQQSLEL FQSCAILNPN SADNLKQVAR SLFLLGKHKA AIEFYHEAAR LNENDWEISH
NLGLCYFFIK DFKNAEEHLK IALKINKHDK TFMMLGKVHL LAGETDKAIE VYKKAVEFSP
ENTEILTTLG LLFLQLGKYQ KAFEHLGNAL TFDPNNYKAI LAAGSMMQTH GDFDVAMNKY
RVAACAVPES PPLWNNIGMC FFGKKKYVAA ISCLKRAHYL SPFDWKVLYN LGLVHLTMQQ
YASAFHFLSA AINLNPRMGE LYMLLAVALT NLEDVENATR SYEQAVTLDE SNPLVNLNFA
IFLYNHGDKK GALDQYQEME RKVNILRDSS SNFEFDPELM DMAQKMGAAL QVTEALVWTK
PGKDSKSKPN SAAATKTPGA PLGTNQVLGQ AMSSAASYSK NIQLSTGVSR GPSNAGEPED
DVLEAPSPPS DPPGSPEPAE SDNPKPRTSK MKSKVQE
//
