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Database: UniProt
Entry: I3JEU6_ORENI
LinkDB: I3JEU6_ORENI
Original site: I3JEU6_ORENI 
ID   I3JEU6_ORENI            Unreviewed;      1234 AA.
AC   I3JEU6;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   23-MAY-2018, entry version 33.
DE   SubName: Full=Transient receptor potential cation channel, subfamily M, member 5 {ECO:0000313|Ensembl:ENSONIP00000007387};
GN   Name=trpm5 {ECO:0000313|Ensembl:ENSONIP00000007387};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000007387, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000007387}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [2] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
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DR   EMBL; AERX01024930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005455786.1; XM_005455729.3.
DR   STRING; 8128.ENSONIP00000007387; -.
DR   Ensembl; ENSONIT00000007392; ENSONIP00000007387; ENSONIG00000005867.
DR   GeneID; 100697354; -.
DR   CTD; 29850; -.
DR   eggNOG; KOG3614; Eukaryota.
DR   eggNOG; ENOG410XR5B; LUCA.
DR   GeneTree; ENSGT00760000119127; -.
DR   InParanoid; I3JEU6; -.
DR   OMA; CDLEEVM; -.
DR   OrthoDB; EOG091G035A; -.
DR   TreeFam; TF314204; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005227; F:calcium activated cation channel activity; IEA:InterPro.
DR   GO; GO:0050909; P:sensory perception of taste; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR029577; TRPM5.
DR   PANTHER; PTHR13800:SF5; PTHR13800:SF5; 1.
DR   Pfam; PF00520; Ion_trans; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005207};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    770    795       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    918    939       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    999   1019       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      785   1035       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      598    618       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1234 AA;  140230 MW;  33F77EEB7C13FDAE CRC64;
     MQEGQDTPLG TLQPQTRCLQ CGDTLEWSEE HGVLLGCSCC STVDETLENV ARGLASRMKK
     EKSHWAAGRV GDIDFLGPTK TRGKFVRVRS NTDPVLIYQM LTEEWGLAPP HLVVAVVGGD
     ELAQMRPWLR DTLRKGLVKA AQSTGAWILT NGLRFGITKH LGQAVRDHSL ASTSSKVRVV
     AIGIAPWNMI HNREALLTAK VDEPTVYKPQ DLPHGSVYSL DSHHSHFVLV EEDPNRPGAT
     SEMRVKLLKH ISLQRTGYGG AGSFEIPVLC LLVHGEPRIL KRMYKGIANS TPWLILAGSG
     GVADILVTLM NRGCWDTDSV HELLLDTFPN AHHSTDISNW VKLIQKILDH EHLLTVHDPE
     QESSELDTVI LKALVKACKS QSQEAQDFLD ELKLAVAWNR VDIAKSDIFN GDVEWKACDL
     EEVMMDALIN DKPDFVRLFV DNGVNLGEFL TYGRLQELYW SVSEKSLLHN LLLKKYEEKQ
     LLLGAARTHG PPGHHPSEQG DRKPRFTLYE VAKVLKDFLH DSCKGFYQKT PTEKPAKGRL
     FHTQKNLAEL EERCEHPWRD LFLWAALQNR QQMANYFWAM GPEAVAAALA GCKILKEMAR
     LESEAESARS MKEAKYEQFA LDVFGECYSN SEDRAYALLV RRTHCWSKST VLNLATEADA
     KSFFAHDGVQ ALLTKIWWGS MTTDTAISKL VVSFFCPPLI WTNLIKFSDE ELDNRNAGKQ
     FVELDSLDTE KALLLSDDDD DPLDSSPGGQ ADQSCASVWW RFLLRRWRRF WSAPVTVFLG
     NVIMYFAFLC LFTYVLLLDF RPPPPLGPGA PEIMLYFWVF TLVLEELRQS FFTDEEMSIL
     KKFKLYVEDN WNKCDMVAIS LFVVGVSCRM VNDTYEAGRT VLAIDFMVFT LRLIHIFAIH
     KQLGPKIIIV ERMMKDVFFF LFFLSVWLIA YGVATQALLH PNDQRIDWVF RRALYRPYLH
     IFGQIPLEEI DTARMPEMNC TDDSDEIIEG LRPPCPNIYA NWLVILLLVI YLLVTNVLLM
     NLLIAMFSYT FQVVQGNTDI FWKFQRYNLI VEYHSRPALA PPFIIISHLS QLFLSLIKQP
     ESKQERLERE LPAGLDQRLI TWETVQKENY LAKVERQHWE SSEERLKSTS SKVQSLLKIV
     GGFKDQERRL ASMESQVRYC GEVLSWMAEC FAQSTLKCGK DAPRVPTSLA GDKTDGAAAD
     ASQSQTAKEA KQEEETRPGH PGYGANKKFP YIDE
//
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