ID   I3JF79_ORENI            Unreviewed;      1383 AA.
AC   I3JF79;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 68.
DE   RecName: Full=Ubiquitin carboxyl-terminal hydrolase 47 {ECO:0000256|ARBA:ARBA00026136};
DE   AltName: Full=Deubiquitinating enzyme 47 {ECO:0000256|ARBA:ARBA00030277};
DE   AltName: Full=Ubiquitin thioesterase 47 {ECO:0000256|ARBA:ARBA00029910};
DE   AltName: Full=Ubiquitin-specific-processing protease 47 {ECO:0000256|ARBA:ARBA00032453};
GN   Name=usp47 {ECO:0000313|Ensembl:ENSONIP00000007520.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000007520.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000007520.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   STRING; 8128.ENSONIP00000007520; -.
DR   Ensembl; ENSONIT00000007525.2; ENSONIP00000007520.2; ENSONIG00000005970.2.
DR   eggNOG; KOG4598; Eukaryota.
DR   GeneTree; ENSGT00940000157223; -.
DR   HOGENOM; CLU_002928_0_0_1; -.
DR   InParanoid; I3JF79; -.
DR   OMA; FLCEWIV; -.
DR   TreeFam; TF314142; -.
DR   Proteomes; UP000005207; Linkage group LG1.
DR   GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd02659; peptidase_C19C; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR001394; Peptidase_C19_UCH.
DR   InterPro; IPR045578; USP47_C.
DR   InterPro; IPR018200; USP_CS.
DR   InterPro; IPR028889; USP_dom.
DR   PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR   PANTHER; PTHR24006:SF902; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 47; 1.
DR   Pfam; PF00443; UCH; 1.
DR   Pfam; PF19718; USP47_C; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   PROSITE; PS00972; USP_1; 1.
DR   PROSITE; PS00973; USP_2; 1.
DR   PROSITE; PS50235; USP_3; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          192..565
FT                   /note="USP"
FT                   /evidence="ECO:0000259|PROSITE:PS50235"
FT   REGION          106..125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          131..153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          425..453
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          877..915
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          931..1031
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        436..453
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        877..893
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        958..999
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1000..1018
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1383 AA;  156821 MW;  4A70B96AEED7DB93 CRC64;
     MEMVPSEENQ FVPKEGVFWS CRQSIFDEMK RISQIQNAAE EPRALCIIQD ITSAKTVNER
     LTLNLPASTT LSKLYEDVAH KAGYVNGTFG LAWGNTQDMA PLDHSSEMSL SESGFEPGGK
     RNFLQLTDKD GEQPQIASDE SGTADSSGLD DSSQERFIGP LLRDGTPGYS GDYSSPSYSY
     SSILSKSETG YVGLVNQAMT CYLNSLLQTL FMTPEFRNAL YNWEFEEQEE DPVTSIPYQL
     QRLFVLLQTS KKRAIETTDV TRSFGWDSSE AWQQHDVQEL CRVMFDALEQ KWKQTEQADL
     INQLYQGKLK DYVRCLECGY ESWRIDTYLD IPLVIRPFGA SQAYGSVEEA LQAFIQPETL
     DGPNQYFCER CKKKCDARKG LRFLHFPYLL TLQLKRFDFD YTTMHRIKLN DRMTFPEELD
     MSPFIDVEDE KSPQTESCTD SGAENEGSCH SDQMSNDFST DDCVDEGICL DSTSSTERVL
     KPKSLLTFEL FSVMVHSGSA AGGHYYACIK SFSDGQWYSF NDQHVSKITQ DDIRKTYGGS
     SGSRGYYSGA FASSTNAYML IYRLKDPSRN AKFLAVEDFP EHIKRLVQKE KESEEQEKRQ
     REIERNTCKI KLFCMHPVKM MMESKLEVHK DKTLREATEM AYKMMELEGV VPLDCCRLVK
     YDEFHEYLER SYEGEEDTPM GLLLGGVKSS YMFDLLLETR RPDQVFQPYK PGEVMVKVHV
     VDLKSETIAS PVSVRAYLNQ TITEFKQLIA QAAGLSAETM RVVLERCYND LRLLYVPNKT
     LKAEGFFRSN KVFVESSELT DHQVPFTDSL LWKLLDRHGN TIRLLVLLPE QSPGTLANRT
     LFQKVGSESD VLSEGSKGNR KSVEAILEES TEKLKNLSLQ QQQGSSTSDS QKSSDASDFE
     HIESPTQEAD SNSSLCVAAD NRELENRIRA TSAGSGGASS DPENHFACEE RSDSEVNNDR
     STSSVDSDIL SSSHSSDTLC NADSGPIQLA NGLDSHSITS SRRSKAHEGK KETWDTAEED
     SGTDSEYDDN GKSKAEAQYL YFRAEPCSQD DASWDSQKCL VVHVDKRITL AAFKLNLEPY
     VGVTSTQFKV FRVYANNQEF ESVRLNETLS SFSDDNKITI RLGRALKKGE YRVKVYQLLV
     NEPEPCKFLV DTVFAKGMTV RQSKEELLPQ LKEQCKLDLS IDRVRLRKKT WKNPGTVFLD
     YHVYEEDISI SSNWEVFLEV LDEPEKMKSM SQLAVLTRRW SPSTMKLGPF QEVILESSSV
     EELKEKLSEI SGIPLENLEF AKGRGTFPCD ISVLEIHQDL DWNPKVSTLN VWPLYICDDG
     AVVFYRDSTE EPLELSEDER NELMKKESSR LLKTGHRVSY SPRKEKALKI YLDGGPAKDP
     GQD
//