ID   I3JGB5_ORENI            Unreviewed;       585 AA.
AC   I3JGB5;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 45.
DE   SubName: Full=Cytosolic phospholipase A2 gamma {ECO:0000313|Ensembl:ENSONIP00000007906.2};
GN   Name=LOC100690648 {ECO:0000313|Ensembl:ENSONIP00000007906.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000007906.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000007906.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_005468660.3; XM_005468603.3.
DR   AlphaFoldDB; I3JGB5; -.
DR   STRING; 8128.ENSONIP00000007906; -.
DR   Ensembl; ENSONIT00000007911.2; ENSONIP00000007906.2; ENSONIG00000006275.2.
DR   GeneID; 100690648; -.
DR   KEGG; onl:100690648; -.
DR   GeneTree; ENSGT01030000234606; -.
DR   InParanoid; I3JGB5; -.
DR   OMA; WEWGTTR; -.
DR   OrthoDB; 4616259at2759; -.
DR   Proteomes; UP000005207; Linkage group LG4.
DR   GO; GO:0004620; F:phospholipase activity; IEA:InterPro.
DR   GO; GO:0009395; P:phospholipid catabolic process; IEA:InterPro.
DR   Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR002642; LysoPLipase_cat_dom.
DR   PANTHER; PTHR10728; CYTOSOLIC PHOSPHOLIPASE A2; 1.
DR   PANTHER; PTHR10728:SF39; CYTOSOLIC PHOSPHOLIPASE A2 GAMMA; 1.
DR   Pfam; PF01735; PLA2_B; 1.
DR   SMART; SM00022; PLAc; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   PROSITE; PS51210; PLA2C; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00555};
KW   Lipid degradation {ECO:0000256|PROSITE-ProRule:PRU00555};
KW   Lipid metabolism {ECO:0000256|PROSITE-ProRule:PRU00555};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..585
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5025691377"
FT   DOMAIN          33..585
FT                   /note="PLA2c"
FT                   /evidence="ECO:0000259|PROSITE:PS51210"
SQ   SEQUENCE   585 AA;  65986 MW;  5C50EAD26114B432 CRC64;
     MQTGLTGFMN AVVCLCLVNS VILSQAADNM EGNVALSERP IRQSHSLCAG EKEYVHKRKQ
     IVLHSLNTLE INCTAASVPH IALLASGGGQ RAAVGLVGFL HQMEKEGLLD MLLYLGGVSG
     STWSMASLYN DPQFSTNMDA AVSRLLDSPS VKLEQAVDWL GERAKEEHFS LADIWGVLTS
     AGIMKQMDLR CLSDEANRNA TNPYPIYCAT EKHCFTHGPI EGKWFEISPH EAGFTELGLF
     IEISLLGSKF QNGTLLEKKK EMDMVKLQGI LGCAVADEET LRDFVPQWLN VPGHLDSAAK
     EYLRVWNILD KVIALTRITV QDTTALMYLD KLQKILEDKV NHSQTESVEA ASMEERKTLF
     NQWSQELWAA VETWSQSLDD GAFKTHVSFL IKEVIPLIAE WKWGTTGNFL YQYQVSSVPA
     CLYSNERLQL IDAGLVINVP YPSFLGDKRD IDLIIAPEYS AGNMFETLTL ARDYAAEMEK
     PFPEINDTIL EDRDWPKDCY VLEGKEKEPT IIYMPLFNRR NCKDAEEFKA KMDEFSTFQR
     PFSQEKMKFV LETAKENVKN NKETLLKEIN KAALRRHNKW KAGEP
//