ID   I3JGB8_ORENI            Unreviewed;      1202 AA.
AC   I3JGB8;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 51.
DE   RecName: Full=Cingulin {ECO:0000256|ARBA:ARBA00044075};
GN   Name=tuft1 {ECO:0000313|Ensembl:ENSONIP00000007909.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000007909.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000007909.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Probably plays a role in the formation and regulation of the
CC       tight junction (TJ) paracellular permeability barrier.
CC       {ECO:0000256|ARBA:ARBA00043864}.
CC   -!- SIMILARITY: Belongs to the cingulin family.
CC       {ECO:0000256|ARBA:ARBA00038467}.
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DR   AlphaFoldDB; I3JGB8; -.
DR   Ensembl; ENSONIT00000007914.2; ENSONIP00000007909.2; ENSONIG00000006277.2.
DR   GeneTree; ENSGT00940000154489; -.
DR   HOGENOM; CLU_002036_0_0_1; -.
DR   InParanoid; I3JGB8; -.
DR   OMA; HWREMFQ; -.
DR   Proteomes; UP000005207; Linkage group LG11.
DR   GO; GO:0016459; C:myosin complex; IEA:InterPro.
DR   Gene3D; 1.10.287.1490; -; 1.
DR   InterPro; IPR002928; Myosin_tail.
DR   PANTHER; PTHR46349:SF4; CINGULIN; 1.
DR   PANTHER; PTHR46349; CINGULIN-LIKE PROTEIN 1-RELATED; 1.
DR   Pfam; PF01576; Myosin_tail_1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          907..1156
FT                   /note="Myosin tail"
FT                   /evidence="ECO:0000259|Pfam:PF01576"
FT   REGION          23..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          80..282
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          570..630
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          807..832
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          356..567
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        159..174
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..282
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        592..611
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        612..630
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1202 AA;  137735 MW;  DD4686CF4D2C218D CRC64;
     MTTPSSGQTT PVDYGVQIRF INDYQNGGGQ PAPQPKTKTQ TTSKYGVAVR VQGIAGQPYV
     VLKDGQKGDS YGVQLKTEYS GYNSLPRNRG KAEPGTEGGY IGGGEQGGLL RRAQSHGSLL
     DRDGGPSNEE YQLSRPPGDG KSGSYGNLDG GIGVRGDREQ GWHVSDRERG TERNIWHGSY
     QAGLNRSLGS VRDSPEPPPQ PNELHSNKRQ TSVNKLINRF DSVNAGGQQR GLPPAQQHPG
     ATSPLTTANP YTSPPSSTHS SLRRSQGNVT KIPGQPANQW ASLEPQRPNL TEAQVTPDLL
     LDQGQSAELS SEEEQAMKTI YNILRQGSSE TDVIVRHKVN LIFQNIQHLK PKQSMREEWM
     SEKRKLEEKV VALQTALLEE RKDSVSNSDP ALKAELESCL DENLQLQEML DRKKNELNET
     QSELTQLRMD RENAEKRVRD MEDQMAEFQD ELRRENSNKT DLVSSQAQLM EVLQLKKKLE
     ETLRQREREL TALKGALKEE VASHDKEIEA MREQYSADMD KLRSSMEQVS QSHAGIEAER
     LRVNASVRSL QQQLEDCRDE SSHWMEQFHS TRDELRTTKQ EEPPSHPETQ LLQTRLEKEE
     FEEELKELQD KMTSMKQQTP DPNHTQTLSQ ELQQCKADLQ KGKSEVEKMR VEFDKKVMEV
     ISLKKSHQNQ EAELKYEIDR LKGQLQKAKE DFTKAQEKNK RLPDPATISE LEQKLNEAQS
     EVTQLKKKLS LTEEELDTSK TQLSRAHLDI NSFQDAQQEQ EEATARLKEK ISRLEAQLQS
     NATESSEAEL ALHTEVRGLR SELDEAKRKA SRLSQEHREL SQRLEDTEKD KEALKQTISQ
     LEDTKRQQER ALEKVNKDYD SLNVSLREET QALRVQLEEQ KERARKEMQE VQRHENDAHS
     ELEKSKMNIR KLEEEISRQK KELLLACEER DNHQLDKELL ANRLRHLEGE LEASKNSHNE
     KTREIRILED KLKRLELEVE EERSSVDMLT DRVARSRDQI DQLRSELMQE RSSKQDLELD
     KNAMERHLKE LRSRVVDMEG QSRSSVGVSQ LESKIQELED RLRSEEREKN AVLATQRRLE
     RKLKDLNMTL DEERQTHTEQ RDQLALRVKA LKRQVDEGET ELERLDGMRR KAQRDLEEQM
     ELKEALQTRV TALETELKRK TQAAIRPALD SSALSSDDDD SLYDSSTITS ILTETNLQTS
     SC
//