ID I3JGF5_ORENI Unreviewed; 552 AA.
AC I3JGF5;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=MAGUK p55 subfamily member 2 {ECO:0000313|Ensembl:ENSONIP00000007946.2};
GN Name=LOC100701914 {ECO:0000313|Ensembl:ENSONIP00000007946.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000007946.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000007946.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MAGUK family.
CC {ECO:0000256|ARBA:ARBA00007014}.
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DR RefSeq; XP_005468654.1; XM_005468597.3.
DR AlphaFoldDB; I3JGF5; -.
DR Ensembl; ENSONIT00000007951.2; ENSONIP00000007946.2; ENSONIG00000006302.2.
DR GeneID; 100701914; -.
DR KEGG; onl:100701914; -.
DR CTD; 562207; -.
DR GeneTree; ENSGT00940000155348; -.
DR OrthoDB; 2873706at2759; -.
DR Proteomes; UP000005207; Linkage group LG4.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.10.287.650; L27 domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR014775; L27_C.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23122:SF68; MEMBRANE PROTEIN, PALMITOYLATED 2A (MAGUK P55 SUBFAMILY MEMBER 2); 1.
DR PANTHER; PTHR23122; MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF02828; L27; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00569; L27; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF101288; L27 domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS51022; L27; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 55..113
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 141..220
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 226..294
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 350..537
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 552 AA; 61936 MW; 020DCB9295D93B37 CRC64;
MPVASTRTEP VPQVLDAMSD STASSTTAND LDLIYLKGIM ESPLEQEESL KEPRLSPVRE
NNVELLQEIL RDLDPFTNRS DTAAELARIL TQPHFQSLLE THDSVAAQAC ESPPPSPCDF
VDHEPEDSQA HNHLPPDAIR MVGIRKIAGE HLGVTFKVEG GELVIARILH GGMIDQQGLL
HVGDIIKEVN GREVGRDPRV LQEELQAASG IVVLKILPSY HESIPPVQVF FKCHYDYDPA
NDNLIPCKEA GLRFETGDIL QIVNQDDVNW WQARHVEGGS AGLIPSQMLE EKRKAFVKRD
VELAPAGNLC TGVGGKKKKK MMYVTTKNAE FDRHEILLYE EVAKVPPFKR KTLILIGAQG
VGRRRLKNKL LLRDPQLFGT IIPYTSRKPK KGERESRMFA FITRSKMETD IKNGRYLEHG
EYEGNLYGLK IDSIHEVVEA GRVCILDANP QSLKVLRTSE FLPYIVFLQA PEFEVLKAIN
QSAVEAGVVT KTLMDEELQR TCDESAKIQT AYGHYFDLSI VNDNLDETYR TVKAALETVS
KNPQWVPVTW VF
//
