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Database: UniProt
Entry: I3JGJ6_ORENI
LinkDB: I3JGJ6_ORENI
Original site: I3JGJ6_ORENI 
ID   I3JGJ6_ORENI            Unreviewed;      1208 AA.
AC   I3JGJ6;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   24-JAN-2024, entry version 60.
DE   SubName: Full=Adenosine deaminase RNA specific {ECO:0000313|Ensembl:ENSONIP00000007987.2};
GN   Name=adar {ECO:0000313|Ensembl:ENSONIP00000007987.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000007987.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000007987.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
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DR   AlphaFoldDB; I3JGJ6; -.
DR   STRING; 8128.ENSONIP00000030791; -.
DR   Ensembl; ENSONIT00000007992.2; ENSONIP00000007987.2; ENSONIG00000006335.2.
DR   eggNOG; KOG2777; Eukaryota.
DR   GeneTree; ENSGT00940000157243; -.
DR   HOGENOM; CLU_005382_0_1_1; -.
DR   TreeFam; TF315806; -.
DR   Proteomes; UP000005207; Linkage group LG11.
DR   GO; GO:0003726; F:double-stranded RNA adenosine deaminase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   CDD; cd19913; DSRM_DRADA_rpt1; 1.
DR   CDD; cd19915; DSRM_DRADA_rpt3; 1.
DR   Gene3D; 3.30.160.20; -; 2.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR   InterPro; IPR002466; A_deamin.
DR   InterPro; IPR044456; ADAR1_DSRM_1.
DR   InterPro; IPR044457; ADAR1_DSRM_3.
DR   InterPro; IPR014720; dsRBD_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR042371; Z_dom.
DR   PANTHER; PTHR10910:SF107; DOUBLE-STRANDED RNA-SPECIFIC ADENOSINE DEAMINASE; 1.
DR   PANTHER; PTHR10910; EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN; 1.
DR   Pfam; PF02137; A_deamin; 1.
DR   Pfam; PF00035; dsrm; 2.
DR   Pfam; PF02295; z-alpha; 2.
DR   SMART; SM00552; ADEAMc; 1.
DR   SMART; SM00358; DSRM; 2.
DR   SMART; SM00550; Zalpha; 2.
DR   SUPFAM; SSF54768; dsRNA-binding domain-like; 2.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR   PROSITE; PS50141; A_DEAMIN_EDITASE; 1.
DR   PROSITE; PS50137; DS_RBD; 2.
DR   PROSITE; PS50139; Z_BINDING; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT   DOMAIN          254..320
FT                   /note="Z-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50139"
FT   DOMAIN          341..406
FT                   /note="Z-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50139"
FT   DOMAIN          539..607
FT                   /note="DRBM"
FT                   /evidence="ECO:0000259|PROSITE:PS50137"
FT   DOMAIN          716..784
FT                   /note="DRBM"
FT                   /evidence="ECO:0000259|PROSITE:PS50137"
FT   DOMAIN          852..1184
FT                   /note="A to I editase"
FT                   /evidence="ECO:0000259|PROSITE:PS50141"
FT   REGION          1..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          121..188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          227..246
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          325..345
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1186..1208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..23
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        138..165
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1208 AA;  132459 MW;  A44E9BDDAF99C244 CRC64;
     MSRGRGGPSK EHYYRHPPPH VQARDNFHRP GTGVFYPRAG PQQIPHPSYY DGPAHPEAHI
     QPSSPLIPST PPTPSHIKVV PNSVTHNSLY SQNHGAGSSP NSFHDKQREF LTGQISEAPQ
     FRATVSRGGG GGGFVPNRSH STIYQPQSGY CRYPNPSNSS PRGRGGYSQD RRPYRPGAGS
     SRGNLAPRHL NQNQFQGKNY NQHSSRQWRT QTDSLCDKFQ SLLLKDRPNR EGERFDRHPS
     SSSSGNLSFC KPNITLTTEI QGEVHEALGA LKPSESISAK VLARKLHLPK KVVNKALYSL
     EHLQKASKQG LTPPEWTLYR EPLRVEEDQT SSEPPQKPEE KSSAQEQKEQ IFKYLLQSRE
     ATALNIAKNI GLKTAKQVNS TLYALEKQGE VVRNVEVNPP TWELSTHRRE RMERSLKAAQ
     SNPAVLVKME VEEEEVSAIF SPSPLPPLPG LEVLTGGWIP DQILSEAPLS SASGKSENAN
     EGQWSTDDIP EFLNAIRRET DAEKKAAEKA NAMGTVAVSV AAPPPQNLWA KLQEVRLKNP
     VSGLMEYAQY LGQNCEFLLL DQSGPSHDPR FRMQVMLNGR LFPVAEASSK KVAKKDAAAA
     TLRILVKEMQ GGTCTADEEN TGNVEQVMEL LPDTSVKIIF VTSVTKLFSL MFTSFFCTTA
     SPVCLLQPQL PLGPSSGSDE SFSGATCPSL PPLTADELRA AHEAGVGDLI NHLNNNAVSG
     LLEYARARGF AAEIRLVGQS GPPHDPKFTY QAKLGGRWFP PVCASNKKQG KQEAADAALR
     VLIGEAERAA RTGELTPAEL PVSGSTLHDQ IAMLSHQRFN ALTTRIQHCL LGRKILATII
     MRRGEGLGTV VSLGTGNRCV KGEELSLKGE TVNDCHAEII SRRGFIRFLY SELFKHYEGA
     DDSIFEPAEN NKLRIKSDIT FHLYISTAPC GDGALFDKSC SEAGDEAQGH QPLFENVKQG
     KLRTKVENGE GTIPVESSAI VPTWDGIQHG ERLRTMSCSD KILRWNVIGL QGALLTHFLD
     PIYLKSITLG YLYSHGHLTR AVCCRLARDG EAFTQSLPAP FKLNHPEVGR VSVYDSTRHT
     GKTKESSVNW SFPDQHSVEV LDGTKGKVDG TKLAVSRVSK SNLFHLFRSL CQRSGHTDLL
     SLPSYAQAKM SAVSFQQAKQ QFFQALSAHG YGAWIGKPLE EKSFEAGEGN WNNGAPVGNS
     NNVGAVEA
//
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