ID I3JH34_ORENI Unreviewed; 1577 AA.
AC I3JH34;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Helicase with zinc finger {ECO:0000313|Ensembl:ENSONIP00000008177.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000008177.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000008177.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 8128.ENSONIP00000008177; -.
DR Ensembl; ENSONIT00000008182.2; ENSONIP00000008177.2; ENSONIG00000006486.2.
DR eggNOG; KOG1804; Eukaryota.
DR GeneTree; ENSGT00940000156686; -.
DR HOGENOM; CLU_237325_0_0_1; -.
DR InParanoid; I3JH34; -.
DR OMA; ICICHEN; -.
DR TreeFam; TF323999; -.
DR Proteomes; UP000005207; Linkage group LG6.
DR GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd18077; DEXXQc_HELZ; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 4.10.1000.10; Zinc finger, CCCH-type; 1.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR049569; HELZ_DEAD-box_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF365; HELICASE WITH ZINC FINGER DOMAIN-RELATED; 1.
DR Pfam; PF13086; AAA_11; 2.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF00642; zf-CCCH; 1.
DR SMART; SM00356; ZnF_C3H1; 1.
DR SUPFAM; SSF90229; CCCH zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00723}; Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00723};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00723}.
FT DOMAIN 122..150
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT ZN_FING 122..150
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT REGION 1060..1081
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1178..1263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1276..1353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1385..1461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1475..1502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1514..1577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1060..1077
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1207..1224
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1280..1336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1385..1406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1424..1452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1516..1565
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1577 AA; 177837 MW; 490A44E345F3A58B CRC64;
MADRRAEKSC EEASRSLARR EYEAAVSHST DALVVLAPQP PSSSTPIPLS PPSLVAAAGP
LRSRALLYRI AAFLQLPKAF FRLKMLLSEI EVRSYIDHPS YTLTEVQDGW RFRPPPRGVT
SSEEYTLCKR YLEQGLCRYG AQCTSAHSQE ELMEWQKRYA SRLIRLKQQQ ESKHFTENYM
ETLIEKWMNS LSPEKVLSDC LEGVNVETTS SLSVTVTTKK SSHSWVFSLL CKPPRKLYRI
ALLYDAHRPH FFITGVSAGE RLQGVPKGCQ EWTPGEETAD NGLDHCVYKV AVGFSTEIFG
TFRQTIVFDF GSEPVLMQRI MVDAASIEDL EHLLAARQQL LMTAKRWDSS CKTIVEFSPN
ETMAELERSL LSRYQIPLSA DQLFTQSVLD KTLTKDNYQA RLHDLLYIEE IAQYKEVSKF
NIKVNLQLVT SFMLTGISVG AKYAQNGQLF ARFKLNETLS EDTLAGRLVM TKVNSVLLLP
LGREAVNSQP PPGVKERVYE AVIEEKTKDY IFLRICKDCC EELGLQPDRE LQVELQFQLN
RLPLCEMHYA LDRIKDNTIL FPDVSLVPTI PWSPNRQWDE QLDPRLNAKQ KEAILAITTP
ISIPLPPILI IGPYGTGKTF TLAQAVKHIL RQDHSRVLIC THSNSAADLY IKDYLHPYFE
AGNQHARPLR VYFRNRWVKT VHPVVQQYCL ISNTQVTFQM PTREDILRHR VVVVTLSTSQ
YLCQLDLEPG LFTHILLDEA AQAMECETIM PFALASKTTR IVLAGDHMQL SPFVYSEFAR
ERNLHVSLLD RLYEHYPPEF PCRILLCENY RSHEAIINYT SELFYDGKLM ASGKQPSHKD
FYPLTFFTAR GEDVQEKNST AYYNNAEVFE IVERVEELRK KWPVAWGKLD EGSIGVVSPY
ADQVFRIRAE LRKKRMPEVS VERVLNVQGK QFRVLFLSTV RTRHTCKHKQ TAIKRKEQLV
EDSTEDLDYG FLSNYKLLNT AITRAQSLVA VVGDPIALCS VGRCRKFWEH FISICHENSS
LHGITFEQIK AQLEALELKK TYVLNPLAPE FIPRALRPLQ GHHSSSQQQQ QSPPKVRFQP
NPAVLMGNPI RAFTPPLGGT PAGMGKSPSP VQRIDPHTGA SILYVPAVYG GNMVMPMPLH
LPWPGYQNRF AVDPRIMGHP AAMAYNFNLL QPPNRGSPIP YSGVAHPSPL GLTQPSPDKE
PSDPIRNDTG QSRSLDSQTE SLVGFPNPLL HRKDPSAAQR PLNFQLAPPT TPFPSNPISG
RTFPQQYPVT RLPYRVSQPQ HPGMAQQNQQ QQQQLSPAYT GGSHNASFFS GPIPTHRPVQ
SPTLNGPDSG GVEEMSSSVR TPMGHPVGHH SGLSHNLILM APQEQPEPRE AVEMQPPPQS
RLLQYRQSQP RGSGDPSSSL GAISNQAGPF PSGLYPHDTG RDLLNENLLN NQGLQQHPGN
PLYNTGSFPH QPPAQSASPP PAQVKYLLQE AQWPHGGATV SPPQQNPLMG NQGHGLPYGL
PIMAHPSRQE QVHLMQLHHQ HQQQQQQQQQ QQQQQQQQQQ QQQQQNQGPD QESYHPLSPR
TSAATAHHNV DEVRALH
//
