ID I3JH49_ORENI Unreviewed; 961 AA.
AC I3JH49;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Toll-like receptor 13 {ECO:0000313|Ensembl:ENSONIP00000008192.2};
GN Name=LOC100692776 {ECO:0000313|Ensembl:ENSONIP00000008192.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000008192.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000008192.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR AlphaFoldDB; I3JH49; -.
DR STRING; 8128.ENSONIP00000042046; -.
DR Ensembl; ENSONIT00000008197.2; ENSONIP00000008192.2; ENSONIG00000006496.2.
DR eggNOG; KOG4641; Eukaryota.
DR GeneTree; ENSGT00940000163999; -.
DR HOGENOM; CLU_006000_4_0_1; -.
DR TreeFam; TF351113; -.
DR Proteomes; UP000005207; Linkage group LG9.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 5.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF541; MSTPROX-RELATED; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00364; LRR_BAC; 3.
DR SMART; SM00365; LRR_SD22; 12.
DR SMART; SM00369; LRR_TYP; 17.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 4.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 744..767
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 773..790
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 801..942
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 961 AA; 111003 MW; 02E8EDF0296A0AA8 CRC64;
MDPGMHEEQS NLERGTKCCK PDIIFLTLSI IGFLVPVEGF SLKTCRISYS TAICVRSKLR
AVPGDIPSTV TGLDLTSNII STIHASDFKD LVNLTKLDLN SNNISQIESG AFASLSSLET
LNLNNNKLVT LGENVFDGLS RLIELRINQN RIKQVASTSF KSMTSLKLLD ISHNKLHHIT
KVQLLLQHLP HLRELVISNN DLTTFQSFEL TNKSLELQYL DLSKNPLAVF RITADVFPNL
TWFKIGSPAR KKQMIWDVQN KTFLSRVTTL DISELHLGLG DMERLLESVN SSLTILRMNA
MTHNLTALIN ISCTIPTMRT LQLRSNKLSF VNAYLFKLCI NVTELDLTNN QIKYIHDDAF
RSLKNLRILT LSKNRLPLVP AATRNLPSLS ELDLSTNNIS TLDCHDFTNQ TKLRKLYLYQ
NSITALKPCL FKDLKGLETL KLQTNQITKL NGAFKEHLPK LRYLYLNINK LTAIKKDEFK
GLHSLQNLSL DQNQIEILDH KSFVGLTNLT RLHLQRNSIK QDKLQKGIFS PLIKLRTLDL
SENRINYNES RNLPDPPFSQ LSHLEELLVF SQHHRLHSYL PVNFLQGLTN LLSFKARNIR
IASLDKDTFV YTPQLQLLEL SSNELKELPP DLFFPIPNLK SLYISRTALY SLDFLIDANL
TKLEFLQARQ NLYSVIRKED IHSLPALTYL DLQGNGFTCN CDNSWFLSWA IHDSKTQVYD
AYNFTCNYPQ EFKSKKLLDF DTRFCSVDMG FIYFLCTICA ILCFMVVSFT YHFMRLHLVY
AYYLFIAWFF DKKHKNKKTP LQYDAFISYN THDEPWVIDK LLPKLEGEQG WRLCLHHRDF
EPGRPIIDNI TDAIYGSRKT ICVISRKYLE SEWCSREIQA ASFRLFDEQT DVLILVFMEE
IPSYLLSPYH RMRKMLKKKT YLSWPRAGEH TELFWEKLCQ ALETREDPEA KTLLLTVPTM
P
//
