ID I3JHI6_ORENI Unreviewed; 329 AA.
AC I3JHI6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Fucolectin-1 {ECO:0000313|Ensembl:ENSONIP00000008330.2};
GN Name=LOC100693362 {ECO:0000313|Ensembl:ENSONIP00000008330.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000008330.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000008330.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Acts as a defensive agent. Recognizes blood group fucosylated
CC oligosaccharides including A, B, H and Lewis B-type antigens. Does not
CC recognize Lewis A antigen and has low affinity for monovalent haptens.
CC {ECO:0000256|ARBA:ARBA00002219}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000256|ARBA:ARBA00011233}.
CC -!- SIMILARITY: Belongs to the fucolectin family.
CC {ECO:0000256|ARBA:ARBA00010147}.
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DR AlphaFoldDB; I3JHI6; -.
DR Ensembl; ENSONIT00000008335.2; ENSONIP00000008330.2; ENSONIG00000006604.2.
DR GeneTree; ENSGT01060000248575; -.
DR HOGENOM; CLU_073092_0_0_1; -.
DR InParanoid; I3JHI6; -.
DR Proteomes; UP000005207; Linkage group LG11.
DR GO; GO:0042806; F:fucose binding; IEA:UniProt.
DR GO; GO:0010185; P:regulation of cellular defense response; IEA:UniProt.
DR GO; GO:0001868; P:regulation of complement activation, lectin pathway; IEA:UniProt.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR006585; FTP1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR PANTHER; PTHR45713; FTP DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45713:SF8; V-FBPL-RELATED; 1.
DR Pfam; PF00754; F5_F8_type_C; 2.
DR SMART; SM00607; FTP; 2.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 2.
PE 3: Inferred from homology;
KW Lectin {ECO:0000256|ARBA:ARBA00022734};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..329
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025678370"
FT DOMAIN 21..167
FT /note="Fucolectin tachylectin-4 pentraxin-1"
FT /evidence="ECO:0000259|SMART:SM00607"
FT DOMAIN 169..308
FT /note="Fucolectin tachylectin-4 pentraxin-1"
FT /evidence="ECO:0000259|SMART:SM00607"
SQ SEQUENCE 329 AA; 36178 MW; 77C00035BFD22025 CRC64;
MKNSSGLLLL LLLGTCSART YQNVALRGKA TQSNELNLEL ADASNAIDGN RESHYWAGSC
IHTDRQTNPW WRVDLLDSYI VTSVIITNRG DCCPEMLNGA EIHIGNSLQD NGAGNPVVAV
VSHIPAGRSL TITFTRLVEG RYVTVVLPGA NRVLHLCEVE VYGYRAPTGE NLALQGKATQ
SSVQTLGYNA YNAIDGNRNS KLEKGSCAQT NYDVSPWWRL DLCKTHKVFS VKIVNSDSDP
ERLNGAEIRI GDSLDNNGNS NPRCAVITSI PAGGIQEFQC NGMDGRYVKQ IFHLQNFNKS
KEIHHPMTTG ISYHRQGTAR QFIRIESEG
//
