GenomeNet

Database: UniProt
Entry: I3JHJ2_ORENI
LinkDB: I3JHJ2_ORENI
Original site: I3JHJ2_ORENI 
ID   I3JHJ2_ORENI            Unreviewed;       328 AA.
AC   I3JHJ2;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   08-NOV-2023, entry version 48.
DE   SubName: Full=Fucolectin-1 {ECO:0000313|Ensembl:ENSONIP00000008336.2};
GN   Name=LOC100693362 {ECO:0000313|Ensembl:ENSONIP00000008336.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000008336.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000008336.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Acts as a defensive agent. Recognizes blood group fucosylated
CC       oligosaccharides including A, B, H and Lewis B-type antigens. Does not
CC       recognize Lewis A antigen and has low affinity for monovalent haptens.
CC       {ECO:0000256|ARBA:ARBA00002219}.
CC   -!- SUBUNIT: Homotrimer. {ECO:0000256|ARBA:ARBA00011233}.
CC   -!- SIMILARITY: Belongs to the fucolectin family.
CC       {ECO:0000256|ARBA:ARBA00010147}.
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DR   AlphaFoldDB; I3JHJ2; -.
DR   Ensembl; ENSONIT00000008341.2; ENSONIP00000008336.2; ENSONIG00000006604.2.
DR   GeneTree; ENSGT01060000248575; -.
DR   HOGENOM; CLU_009725_0_0_1; -.
DR   Proteomes; UP000005207; Linkage group LG11.
DR   GO; GO:0042806; F:fucose binding; IEA:UniProt.
DR   GO; GO:0010185; P:regulation of cellular defense response; IEA:UniProt.
DR   GO; GO:0001868; P:regulation of complement activation, lectin pathway; IEA:UniProt.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR   InterPro; IPR000421; FA58C.
DR   InterPro; IPR006585; FTP1.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   PANTHER; PTHR45713; FTP DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45713:SF8; FTP DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR   Pfam; PF00754; F5_F8_type_C; 2.
DR   SMART; SM00607; FTP; 2.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 2.
PE   3: Inferred from homology;
KW   Lectin {ECO:0000256|ARBA:ARBA00022734};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..328
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5025597072"
FT   DOMAIN          21..167
FT                   /note="Fucolectin tachylectin-4 pentraxin-1"
FT                   /evidence="ECO:0000259|SMART:SM00607"
FT   DOMAIN          169..307
FT                   /note="Fucolectin tachylectin-4 pentraxin-1"
FT                   /evidence="ECO:0000259|SMART:SM00607"
SQ   SEQUENCE   328 AA;  36719 MW;  6C6A4023ED5C62D0 CRC64;
     MMKRSVFFLL LLLRTTLVST YQNLATRGKA TQSTCYPHPR ASALNAIDGN RNSDFMAGSC
     THTNEQTNPW WKVDLLQSYI ITSITVTNRG DCCHERLNGL EIHIGNSLDN DGLDNPKVGR
     ISQIRSGKSS NLTFTNRVEG QYVTLTVLGS QRILTLCEVE IYGYPTPTEE NLALQGKATQ
     SSLYAFGNAF NAIDGNRNSK WEDASCTLTQ KSMSPWWRLD LLKTHKVFSI NIVNQDSLPE
     RLNGAEIRIG DSLHNNGNNN SRCAVITSIP AGGIQEFQCN GMDGRYVKQI FHLQNFNKSK
     EIHHPMTTGI SYHRQGTARQ FIRIESEG
//
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