ID I3JHJ2_ORENI Unreviewed; 328 AA.
AC I3JHJ2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 08-NOV-2023, entry version 48.
DE SubName: Full=Fucolectin-1 {ECO:0000313|Ensembl:ENSONIP00000008336.2};
GN Name=LOC100693362 {ECO:0000313|Ensembl:ENSONIP00000008336.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000008336.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000008336.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: Acts as a defensive agent. Recognizes blood group fucosylated
CC oligosaccharides including A, B, H and Lewis B-type antigens. Does not
CC recognize Lewis A antigen and has low affinity for monovalent haptens.
CC {ECO:0000256|ARBA:ARBA00002219}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000256|ARBA:ARBA00011233}.
CC -!- SIMILARITY: Belongs to the fucolectin family.
CC {ECO:0000256|ARBA:ARBA00010147}.
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DR AlphaFoldDB; I3JHJ2; -.
DR Ensembl; ENSONIT00000008341.2; ENSONIP00000008336.2; ENSONIG00000006604.2.
DR GeneTree; ENSGT01060000248575; -.
DR HOGENOM; CLU_009725_0_0_1; -.
DR Proteomes; UP000005207; Linkage group LG11.
DR GO; GO:0042806; F:fucose binding; IEA:UniProt.
DR GO; GO:0010185; P:regulation of cellular defense response; IEA:UniProt.
DR GO; GO:0001868; P:regulation of complement activation, lectin pathway; IEA:UniProt.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR006585; FTP1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR PANTHER; PTHR45713; FTP DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45713:SF8; FTP DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF00754; F5_F8_type_C; 2.
DR SMART; SM00607; FTP; 2.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 2.
PE 3: Inferred from homology;
KW Lectin {ECO:0000256|ARBA:ARBA00022734};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..328
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025597072"
FT DOMAIN 21..167
FT /note="Fucolectin tachylectin-4 pentraxin-1"
FT /evidence="ECO:0000259|SMART:SM00607"
FT DOMAIN 169..307
FT /note="Fucolectin tachylectin-4 pentraxin-1"
FT /evidence="ECO:0000259|SMART:SM00607"
SQ SEQUENCE 328 AA; 36719 MW; 6C6A4023ED5C62D0 CRC64;
MMKRSVFFLL LLLRTTLVST YQNLATRGKA TQSTCYPHPR ASALNAIDGN RNSDFMAGSC
THTNEQTNPW WKVDLLQSYI ITSITVTNRG DCCHERLNGL EIHIGNSLDN DGLDNPKVGR
ISQIRSGKSS NLTFTNRVEG QYVTLTVLGS QRILTLCEVE IYGYPTPTEE NLALQGKATQ
SSLYAFGNAF NAIDGNRNSK WEDASCTLTQ KSMSPWWRLD LLKTHKVFSI NIVNQDSLPE
RLNGAEIRIG DSLHNNGNNN SRCAVITSIP AGGIQEFQCN GMDGRYVKQI FHLQNFNKSK
EIHHPMTTGI SYHRQGTARQ FIRIESEG
//