ID I3JIE5_ORENI Unreviewed; 818 AA.
AC I3JIE5;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=CSC1-like protein 2 {ECO:0000313|Ensembl:ENSONIP00000008639.2};
GN Name=TMEM63B {ECO:0000313|Ensembl:ENSONIP00000008639.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000008639.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000008639.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR AlphaFoldDB; I3JIE5; -.
DR Ensembl; ENSONIT00000008644.2; ENSONIP00000008639.2; ENSONIG00000006847.2.
DR eggNOG; KOG1134; Eukaryota.
DR GeneTree; ENSGT00940000157084; -.
DR TreeFam; TF324300; -.
DR Proteomes; UP000005207; Linkage group LG6.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR PANTHER; PTHR13018:SF38; CSC1-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 74..93
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 189..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 461..485
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 505..528
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 549..572
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 656..685
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 711..730
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 742..764
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 151..255
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 271..453
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 464..735
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 781..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 790..804
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 818 AA; 93628 MW; 9AE9BB6600CD0E1F CRC64;
MNEIPPSLPE VFCKDAAVSM LRALIVTMAI TGGHACSGQE NCSADVDGES KDYCYSARIR
STVLQGLPFG GVPTVLALDF MCFLVLLFVF SILRKVAWDY GRLALVTDAD RLKKRFSDLE
EREYVASAMH SETPDRYERL TSVSSSVDFD QRDNGFCSWL TAIFRIKDEE IREKCGEDAV
HYLSFQRHII GLLVVVGVLS VGIVLPVNFS GDLLENNAYS FGRTTIANLK SGTNLLWLHT
TFAFMYLLLT VYSMRRHTSK MHYKEDDLVK RTLFINGISK YAEESQIKQH FEQAYENCTV
LEARICYNVA KLMALNAERK KTERSKKFFT DLMAKEHIPT MINPKPCGHL CCCAIAGCEE
EEAVSYYTKR EAKLKEEYRK EKEKVHTKPL GMAFVTFQNE AMTAIILKDF NACQVQGCRC
RQEPRSSQFS EVLHVHNWSV SYAPDPQNVR WEHLSLGGIS WWIRCFVINC ILFILLFFLT
TPAIIITTMD KFNVTKPVEY LNNPIVTQFF PTLLLWAFSA LLPTIVYYSA FFEAHWTRSG
ENRTTMHKCY TFLIFMVLLL PSLGLSSLDV FFRWLFDRKF LADAKVRFEC VFLPDNGAFF
VNYVIASAFI GNAMDLLRIP GLLMYMIRLC LARSAADRRN VKRHQAYEFQ FGAAYAWMMN
VFTVVMAYSI TCPIIVPFGL MYMLLKHLVD RYNMYYAYLP SKLDKKIHSG AVTQVVAAPI
LCLFWLLFFS TVRTGFDTPT SMFTLVVLIV TIVVCLSHVC FGHFKYLSAH NYKIDTKEND
VDAVENGRPA RPSSSPTTKS QQQQKRRQCF RENESTAA
//
