ID I3JIF2_ORENI Unreviewed; 2557 AA.
AC I3JIF2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN Name=usp9x {ECO:0000313|Ensembl:ENSONIP00000008646.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000008646.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Ensembl:ENSONIP00000008646.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SIMILARITY: Belongs to the peptidase C19 family.
CC {ECO:0000256|ARBA:ARBA00009085}.
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DR STRING; 8128.ENSONIP00000076927; -.
DR Ensembl; ENSONIT00000008651.2; ENSONIP00000008646.2; ENSONIG00000006851.2.
DR GeneTree; ENSGT00940000155375; -.
DR Proteomes; UP000005207; Unplaced.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR CDD; cd02659; peptidase_C19C; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021905; DUF3517.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF827; UBIQUITINYL HYDROLASE 1; 1.
DR Pfam; PF12030; DUF3517; 1.
DR Pfam; PF00443; UCH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 1548..1946
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 965..998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1583..1608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2474..2557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 965..992
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2486..2530
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2557 AA; 290236 MW; A5F098EA6BEDDC60 CRC64;
MTATTRGSPV GGNDSQGQGQ APDAQSQPPL PQNQTSSPNS SNENSPVSPP DDQGQGDGPP
QLEEEEPAFP HTDLAKLDDM INRPRWVVPV LPKGELEVLL EAAIDLSKKG LDVKCEACQR
FFRDGLTISF TKILTDEAVS GWKFEIHRCI INNTHRLVEL CVAKLSQDWF PLLELLAMAT
NPHCKFHIYN GTRPSETVPA GAQLADDELY ARPPDPRSPK GWLVDLINKF GTLNGFQILH
DRFMSGQALN VQIIAALIKP FGQCYEFLTL HTVKKYFLPV IEMVPQFLEN LTDEELKKEA
KNEAKNDALS MIIKSLKNLA SRVPGQEETV KNLEIFRLKM ILRLLQISSF NGKMNALNEV
NKVISSVSYY THRHNPEEEE WLTAERMAEW IQQNHILSIV LRDSLHQPQY VEKLEKILRF
VIKEKALTMQ DLDNIWAAQA GKHEAIVKNV HDLLAKLAWD FSPEQLDHLF DCFKASWTNA
SKKQREKLLE LIRRLAEDDK DGVMAHKVLN LLWNLAHSDD VPVDIMDQAL SAHIKILDYS
CSQDRDTQKI QWIDRFIEEL RTNDKWVIPA LKQIREICSL FGEAPQNLSQ TQRSPHVFYR
HDLINQLQHN HALVTLVAEN LSAYMETMRQ LSKAEFDPQT VRPGSRYSHV QEVQERLNFL
RFLLKDGQLW LCAPQAKQIW KCLAENAVFL CDREACFKWY SKLMGDEPDL DPDINKDFFE
NNVLQLDPSL LTENGMKCFE RFFKAVNCRE GKLVAKRRAY MMDDLELIGL DYLWRVVIQG
SDDIANRAID LLKEIYTNLG PKLQVNQVEI HEDFIQSCFD RLKASYDTLC VLDGDKDSIN
CARQEAIRMV RVLTVLKEYI NECDSDYHEE RTILPMSRAF RGKHITLIVR FPNQGRQVDD
LDIWSHTNDT IGSVRRGILN RIKANAAHTK IELFIGGEVV DPADDRKLIG QLNLKDKTLI
TAKLTQVSAN MPSSPDSSSD SSTGSPGNHG NHYSDGPNPE VESCLPGVIM SLHLRYISFL
WQVADLGCNL NMPLLRDGAR DLMKLMPPDN TTVENLRAVC LDHAKLGENS LSPSLDSRFF
GPSPSQVLYL IEVVYALLMP ASATLGEDAS DFQYNFLKSG GLPLVLSMLT RNNFLPSADM
ETRRGAYLNA LKIAKLLLTA VGFGHVKAVA EACQPNAEGN IPINQATHDQ ALVLQSALQN
IPNPASECML RNVAIRLAQQ ISDEASKYIP DICVIRAIQK IVWASGCGTV QLVFSSNEEI
SKIYEKTNAA KEPDGEDEQV CCEALEVMTL CFALMPTALD TLSKEKAWQT FIIDLLLHCH
SKSVRQMAQE QFFLMATRCC MGHRPLLFFI TLLFTVLGST AKERAKHAGD YFTLLRHLLN
YAYNSNINLP NAEVLLNNEI DWLKRIRDEV KRTGETGVEE TILEGHLGVT KELLAFQTPE
KKYYIGCEKG GANLIKELID DFIFPASNVY LQYMKTGEFP TEQAIPVCST PASINAGFEL
LVALAVGCVR NLKQIVDTLT DMYYLGCETL TEWEYLPPVG PRPNKGFVGL KNAGATCYMN
SVIQQLYMIP PIRNGILAIE GTGTDVDDDM SGDEKQENES NVDPRDEVFS YHHQFDDKPS
SKSEDRKEYN IGVLRHLQVI FGHLAASRLQ YYVPRGFWKQ FRLWGEPVNL REQHDALEFF
NSLVDSLDEA LKALGHPAML SKVLGGSFAD QKICQGCPHR YECEESFTTL NVDIRNHQNL
LDSMEQYVKG DLLEGANAYH CEKCNKKVDT VKRLLIKKLP PVLAIQLKRF DYDWERECAI
KFNDYFEFPR ELDMEPYTVA GVAKLEGDDV NPENQVIQQN EPSEPTPPGS SKYRLVGVLV
HSGQASGGHY YSYIIQRNGG DGEKNRWYKF DDGDVTECKM DDEEEMKNQC FGGEYMGEVF
DHMMKRMSYR RQKRWWNAYI LFYERMDSMD KDSELVKYIS DLNISSTKPH QVKMPGVIEC
SVRKQNVQFM HNRMQYSLEY FQFIKKLLTC NSVYLNPPPG QDHLLPEAEE IAMISAQLAA
RFLFSTGFHT KKVVRGPASD WYDALCILLR HSKNVRYWFA HNVLFAYPNR FSEYLLECPS
AEVRGAFAKL IVFIAHFSLQ DGPCPSPTAS PGPSAQGCDN LSLSDHLLRA VLNLLRREVS
EHGRHLQQYF NLFVMYANLG LAEKTQLLKL NVPATFMLVA LDEGPGPPIK YQYAELGKLY
TVVSQLVRCC DVSSRMQSSI NGNPPLPNPY GDTNLTAPVM PVQQLVAEIL FVRTSYVKKI
IEDCSNSEET VKLLRFSCWE NPQFSSTVLS ELLWQVAYSY TYELRPYLDL LLQILLIEDS
WQTHRIHNAL KGIPDDRDGL FDTIQRSKNH YQKRAYQCIK CMVALFSNCS VAYQILQSNG
DLKRKWTWAV EWLGDELERR PYTGNPQYTY NNWSPPVQSN ETSNGYFLER SHSARMTLAK
ACELCPEEVK QIEPDEQEAP DDQDSSPPED TSLYPHSPGT TQFQQNNHPH GQPYTGPAAQ
HMNNPQRPGP RAQENWEGTE EVAPAPTSTP APAPPKE
//
