ID   I3JIJ9_ORENI            Unreviewed;       884 AA.
AC   I3JIJ9;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   27-MAR-2024, entry version 66.
DE   SubName: Full=Nuclear factor of activated T-cells, cytoplasmic 2 {ECO:0000313|Ensembl:ENSONIP00000008693.1};
GN   Name=LOC100696566 {ECO:0000313|Ensembl:ENSONIP00000008693.1};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000008693.1, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000008693.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_003456168.1; XM_003456120.4.
DR   AlphaFoldDB; I3JIJ9; -.
DR   STRING; 8128.ENSONIP00000008693; -.
DR   Ensembl; ENSONIT00000008698.2; ENSONIP00000008693.1; ENSONIG00000006889.2.
DR   GeneID; 100696566; -.
DR   KEGG; onl:100696566; -.
DR   eggNOG; ENOG502SMMU; Eukaryota.
DR   GeneTree; ENSGT00940000156230; -.
DR   HOGENOM; CLU_010185_1_1_1; -.
DR   InParanoid; I3JIJ9; -.
DR   OMA; IIRRDMK; -.
DR   OrthoDB; 5405363at2759; -.
DR   Proteomes; UP000005207; Linkage group LG5.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR   GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_dom.
DR   InterPro; IPR008366; NFAT.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR   InterPro; IPR032397; RHD_dimer.
DR   InterPro; IPR011539; RHD_DNA_bind_dom.
DR   InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR   PANTHER; PTHR12533; NFAT; 1.
DR   PANTHER; PTHR12533:SF4; NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2; 1.
DR   Pfam; PF16179; RHD_dimer; 1.
DR   Pfam; PF00554; RHD_DNA_bind; 1.
DR   PRINTS; PR01789; NUCFACTORATC.
DR   SMART; SM00429; IPT; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF49417; p53-like transcription factors; 1.
DR   PROSITE; PS50254; REL_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          364..546
FT                   /note="RHD"
FT                   /evidence="ECO:0000259|PROSITE:PS50254"
FT   REGION          62..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          106..154
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          215..269
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        63..86
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        115..131
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   884 AA;  96831 MW;  F5D8D65E497AFE90 CRC64;
     MTSGGLGLTE GLGQDINQEE LDFSDLFLYN QPDFSVGCDK VTDDTGGLLD NDSQPPLLVV
     QPQDPYISTS NPPTSNHDTS SHSTNAGNLS GAVFDTMGLT SRVGIPAPSP RIEITPSGDS
     LSSQTLEPSP VSKARGSYRE CVSPASSNSS TGWGADTYSP LASPCVSPSN VGSCGMGLNP
     LDLCSSLQGI HTSSTHSSPG ASPRNSITDE TYLQPQNRSA SPLPHQRSRS VSPQRGKRFY
     GQTHSSQEGT PVKQRSRSPS PIPSPHDQQG SYYLHQYQAQ AEFHPQVQTT TSGLDEILNS
     SPGRAKIQDC VYGEGYDWAI EQEKMSRGGA EIKPETFYML PTVWPPSHSL HHSGRSAFSG
     LALAPLPSLE WSLPSQTDQY ELLIQQQPRS HHRAHYETEG SRGAVKTPNG GHPEVQLRGY
     QGTSALALQV FIGTADERLL KPHAFYQVHR ITGKTVTTPS MERMINGTKV LEIPLEPKSH
     MRVVIDCVGI LKLRNADIEL RNGETDIGRK NTRVRLVFRV HIPHPGGQLV SLQVASHPIE
     CSQRSAQELP AVERQDLDQC SVLGGQQMVL TGQNFTSDSK VIFSEKTQDG QQIWEVEATV
     DRDKTQANML FVEVPPYRDR SICQPAKVNF CVINGKKKRS QPQHFVYTPM RAIKAEPLDD
     YQLNSYGYSN NQSLSGMSMK SLYCPLEQDN NLQALNVSST LYHLTSVDPR AHMLTPDQLD
     DQPVYYQSRP GTLVNNPVLY HTGNQRYSNC SSALLGGSPM APHPASAPSQ CVSARTPVPK
     LGEGPQVGDS FDPYSMSRNH GYMQTALPLG KSPPLRYIQN QVQAKVGTRV DPGGQPLAQI
     APARGNHEER APEKIMIKQE NLSYAYLEDV NDIIRRDMRG HNGE
//