ID I3JIT5_ORENI Unreviewed; 267 AA.
AC I3JIT5;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Tetraspanin {ECO:0000256|RuleBase:RU361218};
GN Name=tspan14 {ECO:0000313|Ensembl:ENSONIP00000008779.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000008779.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000008779.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361218}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361218}.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC {ECO:0000256|ARBA:ARBA00006840, ECO:0000256|RuleBase:RU361218}.
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DR RefSeq; XP_019222192.1; XM_019366647.1.
DR RefSeq; XP_019222194.1; XM_019366649.1.
DR RefSeq; XP_019222195.1; XM_019366650.1.
DR RefSeq; XP_019222196.1; XM_019366651.1.
DR AlphaFoldDB; I3JIT5; -.
DR Ensembl; ENSONIT00000008784.2; ENSONIP00000008779.2; ENSONIG00000006961.2.
DR GeneID; 100706188; -.
DR KEGG; onl:100706188; -.
DR CTD; 81619; -.
DR GeneTree; ENSGT00940000159235; -.
DR InParanoid; I3JIT5; -.
DR OMA; QRLNHCC; -.
DR OrthoDB; 2879418at2759; -.
DR Proteomes; UP000005207; Linkage group LG13.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd03159; TM4SF9_like_LEL; 1.
DR Gene3D; 1.10.1450.10; Tetraspanin; 1.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR000301; Tetraspanin_animals.
DR InterPro; IPR018503; Tetraspanin_CS.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR PANTHER; PTHR19282; TETRASPANIN; 1.
DR PANTHER; PTHR19282:SF261; TETRASPANIN-14; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
DR PRINTS; PR00259; TMFOUR.
DR SUPFAM; SSF48652; Tetraspanin; 1.
DR PROSITE; PS00421; TM4_1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361218};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transmembrane {ECO:0000256|RuleBase:RU361218};
KW Transmembrane helix {ECO:0000256|RuleBase:RU361218}.
FT TRANSMEM 20..41
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361218"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361218"
FT TRANSMEM 93..115
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361218"
FT TRANSMEM 232..253
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361218"
SQ SEQUENCE 267 AA; 30533 MW; 000F3E6CEA1B9560 CRC64;
MYYYRYENAE INCCYKYLMF SYNIIFWLAG IAFIAAGFWA WSEKGVLMDL TQVTRLHGFD
PVWLVLAVGG ITFILGFAGC VGALRENICL LKFFSGVIGL IFFLELTAAV LAVVFQSQVR
AWINEFFLAN IKGYRDDIDL QNLIDSVQRM NACCGAQTPQ DWNQNVYFSC DENNRSREKC
GVPFSCCIQD PADLVMNTQC GYDVRRNQSE WSKHIYTKGC IAALEDWLPR NLYTVAIVFV
VISLLQMVGI YLARNLIADI EKVKFSY
//
