ID I3JIY0_ORENI Unreviewed; 1598 AA.
AC I3JIY0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=IQ motif containing GTPase activating protein 1 {ECO:0000313|Ensembl:ENSONIP00000008824.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000008824.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000008824.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 8128.ENSONIP00000044437; -.
DR Ensembl; ENSONIT00000008829.2; ENSONIP00000008824.2; ENSONIG00000006998.2.
DR eggNOG; KOG2128; Eukaryota.
DR GeneTree; ENSGT00950000183076; -.
DR HOGENOM; CLU_000972_2_1_1; -.
DR TreeFam; TF313078; -.
DR Proteomes; UP000005207; Linkage group LG1.
DR GO; GO:0120025; C:plasma membrane bounded cell projection; IEA:UniProt.
DR CDD; cd00201; WW; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 4.10.270.10; Myosin, subunit A; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000593; RasGAP_C.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001202; WW_dom.
DR PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR PANTHER; PTHR14149:SF15; RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP1; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 4.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF03836; RasGAP_C; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 4.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF143885; RGC domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50096; IQ; 4.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 31..146
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 639..672
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 961..1194
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
SQ SEQUENCE 1598 AA; 182347 MW; 3CD7D725FDAF5CF4 CRC64;
AERRTVLDGV ERLTAEEMDE RRQQNMAYEY LCHLEEAKRW MEACLDEELP PTTELEEGLR
NGVYLAKLGN FFAPQTVSLK KIYDREQTRY KATGLHFRHT DNVIQWLNAM AEKGLPKIFY
PETTDIYDRK NMPRCIYCIH ALRFVSRPLK EEINNMKSEL EKYGIQMPAF SKIGGILANE
LSVDEAALHA AVIAINEAID QGVPEGTLAA MQNPNAMLVN LDRSCAQQYH DTLYQAKGKK
VANSRKRAER DIYDELLTQA EIQGNVNKVN VNNALSEAEQ ALLSGDEDKL YEALKAMGIQ
NLQPQNKAWY LKQLQGDREN KEQTSPGEAL TKDELQSGVD VANGIAEMLK AVERINNAIR
EGVPEKTVEE LMNPDAQLPE VYPSAADLYQ RELASLQQQS QEGNLTHPEL LVAVEMLSSV
VLMNEALDVR DRAALWKQLS STVTGLSNVE DEYAQRYMDE LMRLKAAARE EGSDYLTWND
IQACIDQVNL AVQEEHERIA AIGLINEALD EGDPTKTLSM LQSPSAKLTD VDPSIAQHYH
DKLLEARREK AHETQDPSAV LWLDEIQDAI LKANQDTKEA LQFSQAIQAV NEAVDSGDAA
QTLAALRSPG AGLYGVTSEC AQTYQDDLAK IKQEKKKEGD NGSEWVKHWV KGGHNYYYNL
QTKEGTWVEP ENFIQNNTQL NKEDIQGVVS GVTTAYNREQ LWLANETLIT KLQARCRGYL
VRKGQKERME FLKSQDPAVT CIQAHWKGYK QRKAFKDRKE YLKDHTAEIQ SMVRMHQARK
KYKDRLKYFE DHIDDVVKIQ AFIRANKARD DYKTLISADN PPMGVVRKFV HLLDHSDQDF
QEELELMRLR EEVVTNIRSN QQLENDLNLM DIKIGLLVKN KITLQEVVSH SKKLTKKNKG
QLSDMMMMTK QKGGLKALSK EKRLKLEAYQ YLFYLLQTNP TYLAKLIFQM PQNKSTKFMD
SVIFTLYNYA SNQREEYLLL KLFKTALQEE IKSKVDQMKE IVTGNPTVIK MVVSFHRGAR
GQNALRQILA PVVKEIMDDK TLNIKTDPVD IYKGWVNQME SQTGEASKLP YDVTPEQAMS
HEEVRTRLEA SIKNMKTITD KFLSAIIVSV EKIPYGMRFI SKVLKDTLHE KFPDATEDEL
LKIVGNLLYY RYMNPAIVAP DAFDIIEMSA GGQLTTEQRR NLGSVAKMLQ HAASNKMFLG
DNAHLNPINE YLSTSYQKFR RFFLAACDVP SLEDKFNVDQ YSDLVTVTKP VIYISIGEII
NTHTLLLDHQ DAIAPEHNDS IHELLEDLGE VPTVESLIGE LCHFFLMGKT EVSLTLTNKF
DVPGEANAEM DAKTLLLNTK RLIVDVIRFQ PGETLTEILD STASPEQEAE YQRAMQRRAI
RDANTPEKMK QVKPVVDDSL TLQGKKDKIK SNLQRLAELG KVHPENRYQD LINDIAKDIR
NQRRYRQRRK AELVKLQQTN AALNSKTNFY NVQIDSYNQY IKTCMDNLAS DNKAKKSKQV
SQKYTAARLH EKGVLISIED LQPNQFKNAI FEISPSETVG VFDVKAKFMG VHLETLQLEY
QDLLQLQYEG VAVMKLFDRA TINVNLLIFL LNKKFYGK
//
