ID   I3JJ35_ORENI            Unreviewed;       630 AA.
AC   I3JJ35;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 70.
DE   SubName: Full=PH and SEC7 domain-containing protein 1 {ECO:0000313|Ensembl:ENSONIP00000008879.2};
GN   Name=LOC100711695 {ECO:0000313|Ensembl:ENSONIP00000008879.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000008879.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000008879.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection, ruffle membrane
CC       {ECO:0000256|ARBA:ARBA00004632}.
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DR   AlphaFoldDB; I3JJ35; -.
DR   STRING; 8128.ENSONIP00000051117; -.
DR   Ensembl; ENSONIT00000008884.2; ENSONIP00000008879.2; ENSONIG00000007035.2.
DR   eggNOG; KOG0932; Eukaryota.
DR   GeneTree; ENSGT00940000155061; -.
DR   HOGENOM; CLU_011021_4_0_1; -.
DR   TreeFam; TF319755; -.
DR   Proteomes; UP000005207; Linkage group LG13.
DR   GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   CDD; cd13295; PH_EFA6; 1.
DR   CDD; cd00171; Sec7; 1.
DR   Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041681; PH_9.
DR   InterPro; IPR001605; PH_dom-spectrin-type.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR023394; Sec7_C_sf.
DR   InterPro; IPR000904; Sec7_dom.
DR   InterPro; IPR035999; Sec7_dom_sf.
DR   PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR10663:SF334; PH AND SEC7 DOMAIN-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF15410; PH_9; 1.
DR   Pfam; PF01369; Sec7; 1.
DR   PRINTS; PR00683; SPECTRINPH.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00222; Sec7; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF48425; Sec7 domain; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50190; SEC7; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          111..287
FT                   /note="SEC7"
FT                   /evidence="ECO:0000259|PROSITE:PS50190"
FT   DOMAIN          337..450
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          563..601
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   630 AA;  70880 MW;  DFF0AE33B5D32EBB CRC64;
     RPHFKSHAVG RFCPRRPSDS NLDSFSRHFE SIMESHRAKG TSYSSLDSVD LLTSGSTSVF
     TFDLPTLTPE IQVGRGEEVC RCFLFAAGCN AVPSVCSEER PLNRPPELLY PQADVAERLA
     LGGSDDALAN GMKPDLQAAK RLAKRLYNLE GFRKSDVARQ LSKNNEFSQM VAEEYLTNFD
     FTGLTIDQAL RTFLRQFALM GETQERERVL AHFSRRYRQC NSESLTSEDS VHTLTCAIML
     LNTDLHGNNV GKRMSCSQFI SNLEGLNNGK DFPKDLLKTL YSSIKNEKLQ WTIDEEELRK
     SMSELADVRT DSASHTMKRL GSSGNPLVGV AHQADGELYK SGFLVRKVHA DPDGKRTPRG
     KRGWKSFYAM LKGMVLYLQK DEYRAEKELT EEDVKNAVSI HHSLAMRAAD YSKRPNVFYL
     RTADWRVFLF QAPNAEQMQS WITRINVVAA MFSAPPFPAA IGSQKKFSRP LLPGSNTKLS
     QEEQVKSHEN RFRAVSSELS DLTASTPDRK VKGRELEEQK LRQEYLEFEK TRYGTYAMLL
     RAKLASGDED LSAFEARLFD DGGLQRAHSS PSLPQDTRRP QSGPRATRRA SRPGNTNTVH
     RSAVPLFPIS LSRNGQLQTF RIKALLPVGA
//