ID I3JJ35_ORENI Unreviewed; 630 AA.
AC I3JJ35;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=PH and SEC7 domain-containing protein 1 {ECO:0000313|Ensembl:ENSONIP00000008879.2};
GN Name=LOC100711695 {ECO:0000313|Ensembl:ENSONIP00000008879.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000008879.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000008879.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, ruffle membrane
CC {ECO:0000256|ARBA:ARBA00004632}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; I3JJ35; -.
DR STRING; 8128.ENSONIP00000051117; -.
DR Ensembl; ENSONIT00000008884.2; ENSONIP00000008879.2; ENSONIG00000007035.2.
DR eggNOG; KOG0932; Eukaryota.
DR GeneTree; ENSGT00940000155061; -.
DR HOGENOM; CLU_011021_4_0_1; -.
DR TreeFam; TF319755; -.
DR Proteomes; UP000005207; Linkage group LG13.
DR GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd13295; PH_EFA6; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001605; PH_dom-spectrin-type.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF334; PH AND SEC7 DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF01369; Sec7; 1.
DR PRINTS; PR00683; SPECTRINPH.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 111..287
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 337..450
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 563..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 630 AA; 70880 MW; DFF0AE33B5D32EBB CRC64;
RPHFKSHAVG RFCPRRPSDS NLDSFSRHFE SIMESHRAKG TSYSSLDSVD LLTSGSTSVF
TFDLPTLTPE IQVGRGEEVC RCFLFAAGCN AVPSVCSEER PLNRPPELLY PQADVAERLA
LGGSDDALAN GMKPDLQAAK RLAKRLYNLE GFRKSDVARQ LSKNNEFSQM VAEEYLTNFD
FTGLTIDQAL RTFLRQFALM GETQERERVL AHFSRRYRQC NSESLTSEDS VHTLTCAIML
LNTDLHGNNV GKRMSCSQFI SNLEGLNNGK DFPKDLLKTL YSSIKNEKLQ WTIDEEELRK
SMSELADVRT DSASHTMKRL GSSGNPLVGV AHQADGELYK SGFLVRKVHA DPDGKRTPRG
KRGWKSFYAM LKGMVLYLQK DEYRAEKELT EEDVKNAVSI HHSLAMRAAD YSKRPNVFYL
RTADWRVFLF QAPNAEQMQS WITRINVVAA MFSAPPFPAA IGSQKKFSRP LLPGSNTKLS
QEEQVKSHEN RFRAVSSELS DLTASTPDRK VKGRELEEQK LRQEYLEFEK TRYGTYAMLL
RAKLASGDED LSAFEARLFD DGGLQRAHSS PSLPQDTRRP QSGPRATRRA SRPGNTNTVH
RSAVPLFPIS LSRNGQLQTF RIKALLPVGA
//