ID   I3JK44_ORENI            Unreviewed;       763 AA.
AC   I3JK44;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 62.
DE   RecName: Full=NACHT domain-containing protein {ECO:0000259|PROSITE:PS50837};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000009238.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000009238.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; I3JK44; -.
DR   STRING; 8128.ENSONIP00000056509; -.
DR   Ensembl; ENSONIT00000009243.2; ENSONIP00000009238.2; ENSONIG00000007325.2.
DR   eggNOG; ENOG502QS9E; Eukaryota.
DR   GeneTree; ENSGT01100000263487; -.
DR   HOGENOM; CLU_002274_4_1_1; -.
DR   InParanoid; I3JK44; -.
DR   OMA; YFCELEF; -.
DR   TreeFam; TF352119; -.
DR   Proteomes; UP000005207; Linkage group LG3.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR029495; NACHT-assoc.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR041075; NOD2_WH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR   PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR   Pfam; PF14484; FISNA; 1.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   SMART; SM01288; FISNA; 1.
DR   SMART; SM00368; LRR_RI; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   PROSITE; PS51450; LRR; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          188..322
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
SQ   SEQUENCE   763 AA;  86575 MW;  573A1B0A2DD9ACE1 CRC64;
     MLLFVDQCQC VQHGSDVWLH DFSLIGSFIN ILFQLVEDNI ITFVKNELKK IQKVLSPDYP
     ECLESQRSSS REAFVKITVD FLRRMKQEEL ADRLQSKLQA AVCHRNLKSA LKKKFQCVFE
     GIAKAGSPTL LNQIYTELYI TEGGTAEVND EHEVRQIETA SRKPDRPETT IRQEDIFKAS
     PGRDEPIRTV LTKGVAGIGK TVLTQKYSLD WAEDKANQDI QFIFPFTFRE LNVLKEEKFS
     LVGLVHHFFN QTNQSGICRL EDFQVVFILD GLDECRLPLD FHKTTILTDP RKSTSVDVLL
     INLIRGKLLP SAHLWITTRP AAANQIPPDC VDMVTEVRGF TDPQKEEYFR KRFRDEEQAS
     RIISHIKKAR SLHIMCHIPV FCWITATVLE DVLETREGGQ LPQTLTEMYI HFLVVQAKVK
     KVKYDGGAET DPHWSPESRK MMESLGKLAF DQLQKGNLIF YEPDLTECGI DIRAASVYSG
     VFTQIFKEER GLYQDKVFCF IHLSVQEFLA ALHVHLTFIN SGLNLLEEQQ TTSMWSKLFD
     KPKLQSLQQS AVNKALQSPN GHLDLFLRFL LGLSLQTNQT LLRGLLIQTG SSSQTNQETV
     QYIKKKLSKN LSAEKSINLF HCLNELNDRS LLEEIQQSLR SGRLSTDKLS PAQWSALVFI
     LLSSEKDLDV FDLQKYSASE EALLRLLPVV KASNKALLSG CNLSERSCDA LSSVLNSQSS
     SLKELDLSNN DLRDSGVKLL SAALQSPRCT LETLRSGSKH IIK
//