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Database: UniProt
Entry: I3JK56_ORENI
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ID   I3JK56_ORENI            Unreviewed;      1840 AA.
AC   I3JK56;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   23-MAY-2018, entry version 44.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000009250, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000009250}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [2] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; AERX01063454; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01063455; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01063456; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01063457; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01063458; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01063459; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01063460; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01063461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8128.ENSONIP00000009250; -.
DR   Ensembl; ENSONIT00000009255; ENSONIP00000009250; ENSONIG00000007334.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; I3JK56; -.
DR   OrthoDB; EOG091G1DMM; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028817; Na_channel_a4suB.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF186; PTHR10037:SF186; 2.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005207};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    156    180       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    192    219       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    240    262       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    393    418       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    708    726       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    738    767       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    773    797       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    818    843       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    873    893       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    905    929       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1181   1204       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1216   1236       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1248   1269       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1290   1316       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1374   1398       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1410   1435       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1493   1512       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1524   1545       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1551   1573       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1611   1639       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1718   1738       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1752   1787       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    1765   1776       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   COILED      434    462       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1840 AA;  210067 MW;  E40DEF99A1352DAC CRC64;
     MVSLLPPVGT EVFRRFTTAS QEVQQQHVAE AKERKTWKDK WVTEKNLPKP AAHLETGKSL
     PLIYGDPPPQ LLNTPLEDLD PFYQSRKTFV VLSKGNIINR FSADSSCYLL SPFNPLRTLA
     IKTLLHPYPS VLIFTTLLQK HVVSCQHFWH RVYSNYVYMA IFIFEALVKI VARGFCVGLF
     TFLRDPWNWL DIIIISTLLV SQFIDLGKFA VLMTISLLYS QRGALFTGLK KTVEALVQSV
     KRLDCVIILT VFCLSILAMI GLQLFMGTLK NKCVIWSMNT NTTEFDFHNH TTSPGMMVVP
     YPDWQVFFQH YNESSENYYY IPGHPDPLVC GNQSDAERCP DGFNCVKAGS NPNFGYTSYD
     SFFWSLMSLF RLMMHDFWEG LMQLTLRAAG KSYLIVFLLV FFPGCFFLLS LILAVVVMTR
     AEQEEAQGAE AIQREEEFRR IVEVLKRREE EEENNKSTLT ASTGIRRAMS SQILIKSNQI
     QFIGWSSVSV CTSLTAEFGS LLWSIQVCAN NTTFSPGLGA APSKTQKQES MIHTRYRCNF
     FTSTQLTALS SSTSVSRLSG SMATTKGRRT NANTGTLGPG VASVAKTCHS CTKCTGITRH
     VTDPADLSAA DASVHLKSGC SKNLSPASSQ LIVQQASSRA ETPEQQDSLQ KKKSAAGIQA
     TKQEHVEEAE EHHRPLCCTC TDAFLKGDCC GCWRWLKQQF HTFITNPFFD LVIISCIIVS
     TIITAIEHYP MMVEFMETLV IAHLVFHGIF AAEMIIKLVA LGLHGYFQVR WHIFDFILVI
     ISLVHLGLAD VEGLSLLRSF LPFRVFRLAR WWPMLHMFLK IVWASVGNLT LVLFITVFMF
     SVAGVQLFQS DYKANVCRIS YDCQLPRWHM EDFFHTFMLV FRVLCGQCLE YLWDCMEVSN
     DGVCVTFFMI VLIVGKLLIL HLFLNLLFIN DQLVDSEDKT TNTLQRTMKQ TRTWIPKSIW
     TLWGSQLSSL IKTQRNTAKA AKARREGWQK VGDKLNSLEP QQDPLEHGAT KKRAEQIKTG
     GGPAPPRVCV PETGCLHTGS DCDSEGLCSL LTGSETKKDN KEEYLTLSSV SSDQLTLDDN
     HTNMAAWEAP VAVAEIEFRT PENAQEKETQ HVKTEISHPE FTDTCDVMQK LKDETHPEPE
     DCCCNRCYIC CPFLEIDTSQ GTGRVWSNFR RACLCIVQHK FFEGFIVFII LLSCAALVFE
     DIYLEHRPVL QRVLKMADLV FTFVFLVEML LKWIAFGFKK YFTSFWCWLD FLILNVTLFS
     LMGNMLGYTS QPLRALRTLR VPSRFKGMRV VLKVLAVTLP SMFSMLLVIL VIWLFFSVIG
     VNLFAGKFYY CYNETSEEIF SFNLVNNKTE CFSLMVMNFS EVNWKTWTFN FDNVGMGFLS
     LLIMGTSSGW MDIMYAAVDS TQPRYEINVY MYMYFICFII IGCFFTLNLF IRVIIDTIHQ
     QRLYFGGKHV FVTDQQQKYL NTIKKRFSEK RNNTIPRPQH CCLAWLFHLV TALYFEIFMV
     VVIFFNMVVL MVETDDQSME KSHVLHWIHF ILVAIFLVEF ILKIIALRQH YFRNGLHIVD
     FVVLTLSIIG LLLSDIFEKY FGSPSLFSVM RLGRLFALCG PFHHIRFARR IWMLIMGFVM
     SLPALFNIGL LFFLIVYTFS IIGMFNFAYV KNEMMIDDMF NFKTFGNSII SMTMITTSSG
     WDGLLSPIMN TPPDCDLRLP DPGNCANPTV GIVFFSSYIL LFCLLVIQLF IVVILELFNT
     ANPEDAEMLS DDHLQMFYET WRKFDPSGSQ VIQYSELADF CDGLQDPLRI PKPNTIKLTH
     LNLPLLPGDQ ISCLDVLRTI TTQVFDEPAE VDALKAKLDE
//
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