ID I3JKA8_ORENI Unreviewed; 1060 AA.
AC I3JKA8;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Rap guanine nucleotide exchange factor 1 {ECO:0000313|Ensembl:ENSONIP00000009302.2};
GN Name=rapgef1 {ECO:0000313|Ensembl:ENSONIP00000009302.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000009302.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000009302.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; I3JKA8; -.
DR Ensembl; ENSONIT00000009307.2; ENSONIP00000009302.2; ENSONIG00000007374.2.
DR GeneTree; ENSGT00940000156235; -.
DR HOGENOM; CLU_003982_1_0_1; -.
DR Proteomes; UP000005207; Linkage group LG7.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 675..793
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 823..1047
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 58..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 590..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..290
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1060 AA; 119659 MW; FB79E18DA7A24113 CRC64;
MATECHIPPL RRSREIKADK GVILSLIKTH TRPVSSHYSQ RSHLSTFTMI LKDKFHSPKI
KRTPSKKGKQ LQPEPAAKST EKPTNKKVSR LEEQEKEVVS ALRYFKTIVD KMVVEKKVLE
MLPGSASKVL EAILPLVQVE ARIQHSSALS SCHSRVYQSL ANLIRWADQV MLDGIDLDDK
ENVASVTNVI KAVLDGVKEL VKLTIEKQEQ PSPTTPNKPA APAALRVPER PLIDREQEVS
SKTAPAAAPV EAAPEVPDEE VAPPKPPLPE AKMAELSPPP ALPPKKRQSA PSPTPVAVVA
PMSRGSSLPC SDHRQVRFLQ RRFSGGSHSY GGDSPRLSPC SSMGKLSKSD EQLSSIEQDS
GQCSRNTSCE TLDHYDPDYD FLHQDLSAGE NLPPIPVGGC LSPLPESHSE SSSPVPGQHP
SHPRFSAPPP QHQDYWTPQP NHTNPLQPSR ISAPPALPMK KRRSTQTSSF SDGGSRVLYE
RFPSQYDNLS EEELHPTPPF PLFTPISPMP QTNGGVFVSQ YVASENADVP ASPPPLPEKK
SKHILQYMQF VEDYSEPQPS VFYQMPQSES IYEQRNKRFQ EVYGFNDSFS STDSVHEPVQ
PPALPPKQRQ LSESANDEGG EGEYVNLYSS SQANGELPLS LRVSTGSDEE DVDELALIDH
KEIMSRITLK QENDDGPDVR AGSGDILLVH ATETDRKDLV LYCEAFLTTY RTFITPEDLI
KKLHYRYPFQ ITLHKRVSKN TFFVLVRVVD ELCLVELTED ILKQLMDLVF TLVCNGELSL
ARVLRKNILD KVEQKKLLRY TNSLKPLAAR GVSARPGTLH DFRSHEIADQ LTLLDAELFY
KIEIPEVLLW AKEQNEEKSP NLTQFTEHFN NMSYWVRSLI IQQEKAQDRE KLLLKFIKIM
KHLRKLNNFN SYLAILSALD SAPIRRLEWQ KQTSEGLEEY CTLIDSSSSF RAYRAALAEV
EPPCIPYLGL ILQDLTFVHL GNPDLIDGKV NFSKRWQQFN ILDSMRRFQQ VHYELKRNED
IVSFFNDFSD HLAEEALWEL SLKIKPRNIS RRKTDREEKT
//
