ID I3JKB5_ORENI Unreviewed; 870 AA.
AC I3JKB5;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Dimethylglycine dehydrogenase {ECO:0000313|Ensembl:ENSONIP00000009309.1};
GN Name=DMGDH {ECO:0000313|Ensembl:ENSONIP00000009309.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000009309.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000009309.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GcvT family.
CC {ECO:0000256|ARBA:ARBA00008609}.
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DR RefSeq; XP_003458628.1; XM_003458580.4.
DR AlphaFoldDB; I3JKB5; -.
DR STRING; 8128.ENSONIP00000009309; -.
DR Ensembl; ENSONIT00000009314.2; ENSONIP00000009309.1; ENSONIG00000007381.2.
DR GeneID; 100707764; -.
DR KEGG; onl:100707764; -.
DR CTD; 29958; -.
DR eggNOG; KOG2844; Eukaryota.
DR GeneTree; ENSGT00940000158176; -.
DR HOGENOM; CLU_007884_11_1_1; -.
DR InParanoid; I3JKB5; -.
DR OMA; NGWERPN; -.
DR OrthoDB; 1815533at2759; -.
DR TreeFam; TF314735; -.
DR Proteomes; UP000005207; Linkage group LG7.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 2.40.30.110; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 3.30.70.1400; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR006076; FAD-dep_OxRdtase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR032503; FAO_M.
DR InterPro; IPR028896; GCST/YgfZ/DmdA.
DR InterPro; IPR013977; GCV_T_C.
DR InterPro; IPR006222; GCV_T_N.
DR InterPro; IPR029043; GcvT/YgfZ_C.
DR InterPro; IPR027266; TrmE/GcvT_dom1.
DR PANTHER; PTHR43757; AMINOMETHYLTRANSFERASE; 1.
DR PANTHER; PTHR43757:SF2; AMINOMETHYLTRANSFERASE, MITOCHONDRIAL; 1.
DR Pfam; PF01266; DAO; 1.
DR Pfam; PF16350; FAO_M; 1.
DR Pfam; PF01571; GCV_T; 1.
DR Pfam; PF08669; GCV_T_C; 1.
DR SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF103025; Folate-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 57..419
FT /note="FAD dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF01266"
FT DOMAIN 422..473
FT /note="FAD dependent oxidoreductase central"
FT /evidence="ECO:0000259|Pfam:PF16350"
FT DOMAIN 484..749
FT /note="Aminomethyltransferase folate-binding"
FT /evidence="ECO:0000259|Pfam:PF01571"
FT DOMAIN 775..852
FT /note="Glycine cleavage T-protein C-terminal barrel"
FT /evidence="ECO:0000259|Pfam:PF08669"
SQ SEQUENCE 870 AA; 96724 MW; 09529EB51ACF3CD8 CRC64;
MARILNLIRV QLRRDLASCR GVAGQPLRTI SCTSRKQAEE SDASSVLGKR WKDTAETVII
GGGCVGVSMA YHLAKAGMKD VVLLEKTELT AGSTWHAAGL TTYYHPGINL KKIHYDSIKL
YETLEAETGQ AVGLHQPGSI RIASTPIRVD EMKYQMTRTH WHVTEQYLIG PEKIQELFPL
LNMDKVLAGL YTPGDGHIDP YSLTMALAAG ARMYGAQIYN NAPVTILKPT SDGKWDVQTS
HGTIRANRIV NTAGFWAREV GKMIGFEHPT IPVHHQYVVT ATIPEVKALK KELAVIRDLE
ASYYLRQERD GLLFGPYEKM EKMVLQDSWV RDGVPPGFGK ELFESDLDRI MEHVEKAMEM
VPVLKKADII NIVSGPITYT PDLLPMVGPH CGVRNYWTAI GFGYGIIHAG GIGKFLSEWI
MNGEPPYDLI ECDPNRYGKW TDVPFMCAKA RESYGFNNVV GYPKEERFAG RPTCRTSGVY
ELLKDKGSMG FHAGWEQPHW FYKPGDDIGY KPSFQRTNWF GPVGRECKLV MEKVGVIDLT
PFGKFIVKGK DSHKLLDRLF ANTMPKVGMT NISHMLTPSG KVYAEVTITQ LALGEFLLVT
GSGSELHDLR WIETEVAQGG YDVDITNVTE DIGVLGIAGP NSRKVLQKLT NEDMSEAGFK
FLHCKSIQLA GKPVRAIRIS YTGELGWELY IDQKDMAAVY LAMVEAGKDE GIDNFGTYAM
ASLRLEKGFR GWGAEMNCDT NPLEAGLDYF IKLNKPADFI GKAALQEIKA KGLKRKLSYI
AVNTDDIDPE GNETVWYNGK VVGNTTSGAY SYSSQQSLAF AYLPLELSTL GQKVEVELLG
KKYPANIIQE PLIHTEPTRT RLQKKAQSKA
//
