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Database: UniProt
Entry: I3JKV6_ORENI
LinkDB: I3JKV6_ORENI
Original site: I3JKV6_ORENI 
ID   I3JKV6_ORENI            Unreviewed;       925 AA.
AC   I3JKV6;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   24-JAN-2024, entry version 74.
DE   SubName: Full=Thrombospondin-4-B {ECO:0000313|Ensembl:ENSONIP00000009500.2};
GN   Name=LOC100696639 {ECO:0000313|Ensembl:ENSONIP00000009500.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000009500.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000009500.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC       {ECO:0000256|ARBA:ARBA00004240}. Sarcoplasmic reticulum
CC       {ECO:0000256|ARBA:ARBA00004369}. Secreted, extracellular space,
CC       extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
CC   -!- SIMILARITY: Belongs to the thrombospondin family.
CC       {ECO:0000256|ARBA:ARBA00009456}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   AlphaFoldDB; I3JKV6; -.
DR   STRING; 8128.ENSONIP00000077190; -.
DR   Ensembl; ENSONIT00000009506.2; ENSONIP00000009500.2; ENSONIG00000007533.2.
DR   eggNOG; ENOG502QRK8; Eukaryota.
DR   GeneTree; ENSGT00940000155227; -.
DR   HOGENOM; CLU_009257_1_1_1; -.
DR   TreeFam; TF324917; -.
DR   Proteomes; UP000005207; Linkage group LG7.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   CDD; cd00054; EGF_CA; 2.
DR   Gene3D; 1.20.5.10; -; 1.
DR   Gene3D; 2.60.120.200; -; 2.
DR   Gene3D; 2.10.25.10; Laminin; 4.
DR   Gene3D; 4.10.1080.10; TSP type-3 repeat; 2.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR003367; Thrombospondin_3-like_rpt.
DR   InterPro; IPR017897; Thrombospondin_3_rpt.
DR   InterPro; IPR008859; Thrombospondin_C.
DR   InterPro; IPR024665; TSP/COMP_coiled-coil.
DR   InterPro; IPR046970; TSP/COMP_coiled-coil_sf.
DR   InterPro; IPR028974; TSP_type-3_rpt.
DR   InterPro; IPR048287; TSPN-like_N.
DR   PANTHER; PTHR10199; THROMBOSPONDIN; 1.
DR   PANTHER; PTHR10199:SF92; THROMBOSPONDIN-4; 1.
DR   Pfam; PF11598; COMP; 1.
DR   Pfam; PF07645; EGF_CA; 2.
DR   Pfam; PF02412; TSP_3; 6.
DR   Pfam; PF05735; TSP_C; 1.
DR   SMART; SM00181; EGF; 4.
DR   SMART; SM00179; EGF_CA; 2.
DR   SMART; SM00210; TSPN; 1.
DR   SUPFAM; SSF58006; Assembly domain of cartilage oligomeric matrix protein; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR   SUPFAM; SSF57196; EGF/Laminin; 1.
DR   SUPFAM; SSF103647; TSP type-3 repeat; 3.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS01187; EGF_CA; 1.
DR   PROSITE; PS51234; TSP3; 3.
DR   PROSITE; PS51236; TSP_CTER; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00634}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW   ProRule:PRU00076}; Mitogen {ECO:0000256|ARBA:ARBA00023246};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Unfolded protein response {ECO:0000256|ARBA:ARBA00023230}.
FT   DOMAIN          313..350
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          410..452
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   REPEAT          486..521
FT                   /note="TSP type-3"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT   REPEAT          545..580
FT                   /note="TSP type-3"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT   REPEAT          682..717
FT                   /note="TSP type-3"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT   DOMAIN          721..910
FT                   /note="TSP C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51236"
FT   REGION          483..555
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          580..671
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        492..506
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        515..555
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        597..618
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        648..662
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   925 AA;  101528 MW;  9143F09CDF7D0C15 CRC64;
     FSAPLRVVNI HVSSSITHVL SRFPAFLSVS TVYDLLTSPD CLPDLLQGGL TGQGVNEAFI
     LTSFKLQPKT GTTVFGLYNP RDNSKYFEFT VMGKLNRAVL RYLRSDKRMA SVTFNNLVLA
     DGQQHRLLFH LRGLQQQQQQ QQGPGGMELH LDCRLVETVR DLPAAFQGLP AGYGTVELKT
     MQAREQESLD ELKLVVGDSF ENVASLQDCH FQQRDSVQTL GVNTKQLSNQ MLELTKVINE
     LKDVLIQQVK ETSFLRNTIS ECQACGLGGT EVVKQRCAPG VCFRDDMCTE TAEGVECGPC
     PDGYTGDGFN CDDVDECQFN PCFPGVRCVN TAPGFRCDAC PLGYTGLPVE GVGIVYAQTN
     KQVCDDIDEC KGPDNGGCTA NSICHNSVGS YHCGSCKSGF TGDQVKGCKP EISCGNSLTN
     PCDVNAQCIV ERDGSISCQC GIGWAGNGYL CGKDMDIDGY PDEKLKCKDP NCRKDNCVFV
     PNSGQEDADR DGYGDACDED ADGDGIPNEQ DNCRLKPNVD QRNSDKDSHG DACDNCRLVE
     NPDQRDTDGD GKGDACDDDM DGDGLKNFLD NCQRVQNRDQ LDRDGDGVGD ACDSCPDIPN
     PNQSDVDNDL VGDSCDTNQD SDGDGHQDTK DNCPLVINSS QLDTDKDGLG DECDDDDDND
     GIPDVLPPGP DNCRLVPNPD QIDDNNDGVG DICESDFDQD KVIDRIDNCP ENAEITLTDF
     RAYQTVVLDP EGDAQIDPNW VVLNQSDIFI YTCYTAFSGV DFEGTFHVNT VTDDDYAGFI
     FGYQDSSSFY VVMWKQTEQT YWQATPFRAV AEPGIQLKAV KSRSGPGEHL RNSLWHTGDT
     TDQVRLLWKD PRNVEGQHCV ARFYEGTELV ADSGVTIDTT MRGGRLGVFC FSQENIIWSN
     LKYRCNDTIP EDFQEFSTQH GVDSL
//
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