ID I3JLM2_ORENI Unreviewed; 657 AA.
AC I3JLM2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000009766.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000009766.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; I3JLM2; -.
DR STRING; 8128.ENSONIP00000009766; -.
DR Ensembl; ENSONIT00000009772.2; ENSONIP00000009766.2; ENSONIG00000007751.2.
DR eggNOG; KOG0578; Eukaryota.
DR GeneTree; ENSGT00940000158656; -.
DR HOGENOM; CLU_000288_26_6_1; -.
DR InParanoid; I3JLM2; -.
DR OMA; QENGDPQ; -.
DR TreeFam; TF105352; -.
DR Proteomes; UP000005207; Linkage group LG14.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01093; CRIB_PAK_like; 1.
DR Gene3D; 3.90.810.10; CRIB domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000095; CRIB_dom.
DR InterPro; IPR036936; CRIB_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR033923; PAK_BD.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR PANTHER; PTHR48015; SERINE/THREONINE-PROTEIN KINASE TAO; 1.
DR PANTHER; PTHR48015:SF17; SERINE_THREONINE-PROTEIN KINASE PAK 4; 1.
DR Pfam; PF00786; PBD; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00285; PBD; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50108; CRIB; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 12..25
FT /note="CRIB"
FT /evidence="ECO:0000259|PROSITE:PS50108"
FT DOMAIN 387..638
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 94..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..145
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..217
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..348
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 417
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 657 AA; 73651 MW; B29083D72D18F8C6 CRC64;
MFAKKKKSRI QISAPSNFEH RVHTDFDEQE QKFVGLPRQW QSLIEDTAQR PKPFIDATII
TTVEPRKTIV RGSRMGTESL TWLLDEFDTM SVTRSNSLRR GSPPTHPRRD SSSSGGGGGQ
ENGDPQYRHY SDRQDRDRPR QDQQSGGDPR HQGQRGVRPP QADEVIQGRP QQQPRGQEPS
RAQRDRQAPP PPPHRDRQPR DRDQRDQPGD HRPKSSYVAR DGSPQSPRDK RPLSGPNIRT
PNLPMSEGVM KTAQQASRPF NTYPRTESDG GRSPTGQVGV GRHHESSPQN GPSSGSVRGS
SGSKPPISHP HPHHSSHPIL APESSQLPHT PHPNVPAPRP PVPSGPAASG APPQGRSPQR
EPQRVSHEQF RAALQMVVDP GDPRTYLDHY IKIGEGSTGI VCIATMKNTG KLVAVKKMDL
RKQQRRELLF NEVVIMRDYH HENVVEMYNS YLVGDELWVV MEFMEGGALT DIVTHTRMNE
EQIATVCLSV LKALSVLHTQ GVIHRDIKSD SILLTHDGRV KLSDFGFCAQ VSKEVQRRKS
LVGTPYWMAP ELISRLPYGP EVDIWSLGIM VIEMVDGEPP YFNEPPLKAM KMIRDNLPPK
LKNLHKVSPL LKSFLDRMLV RDPAQRATAS ELLKHPFLSK GGPPSCIVPL MRQNRMK
//
